Yongkang Yang1, Gang Li1. 1. Department of Orthopaedics & Traumatology, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, P.R.China.
Abstract
OBJECTIVE: To explore the biological mechanisms of tibial transverse transport (TTT) for promoting microcirculation and tissue repair. METHODS: The clinical application and animal model study of TTT were reviewed. RESULTS: The possible biological mechanisms of TTT for promoting microvascular network formation and tissue repair: ① Tibial corticotomy reduces intramedullary pressure and improves microcirculation; ② Tension stress stimulation promotes microvascular regeneration and accelerates the formation of new "transcortical vessels" network; ③ Systemic mobilization of stem cells, mediating local inflammation, etc. CONCLUSION: TTT has been clinically proven to be effective for the management of lower limb ischemia and diabetic foot ulcers. The surgical procedure is relatively easy with little adverse effects on bone structures. The TTT has good application prospects despite the biological mechanisms of which still need further exploration.
OBJECTIVE: To explore the biological mechanisms of tibial transverse transport (TTT) for promoting microcirculation and tissue repair. METHODS: The clinical application and animal model study of TTT were reviewed. RESULTS: The possible biological mechanisms of TTT for promoting microvascular network formation and tissue repair: ① Tibial corticotomy reduces intramedullary pressure and improves microcirculation; ② Tension stress stimulation promotes microvascular regeneration and accelerates the formation of new "transcortical vessels" network; ③ Systemic mobilization of stem cells, mediating local inflammation, etc. CONCLUSION: TTT has been clinically proven to be effective for the management of lower limb ischemia and diabetic foot ulcers. The surgical procedure is relatively easy with little adverse effects on bone structures. The TTT has good application prospects despite the biological mechanisms of which still need further exploration.
Authors: Jia Xu; Yuxin Sun; Tianyi Wu; Yang Liu; Liu Shi; Jinfang Zhang; Qinglin Kang; Yimin Chai; Gang Li Journal: J Tissue Eng Regen Med Date: 2017-11-17 Impact factor: 3.963
Authors: Anika Grüneboom; Ibrahim Hawwari; Daniela Weidner; Stephan Culemann; Sylvia Müller; Sophie Henneberg; Alexandra Brenzel; Simon Merz; Lea Bornemann; Kristina Zec; Manuela Wuelling; Lasse Kling; Mike Hasenberg; Sylvia Voortmann; Stefanie Lang; Wolfgang Baum; Alexandra Ohs; Oliver Kraff; Harald H Quick; Marcus Jäger; Stefan Landgraeber; Marcel Dudda; Renzo Danuser; Jens V Stein; Manfred Rohde; Kolja Gelse; Annette I Garbe; Alexandra Adamczyk; Astrid M Westendorf; Daniel Hoffmann; Silke Christiansen; Daniel Robert Engel; Andrea Vortkamp; Gerhard Krönke; Martin Herrmann; Thomas Kamradt; Georg Schett; Anja Hasenberg; Matthias Gunzer Journal: Nat Metab Date: 2019-01-21