| Literature DB >> 31620676 |
Anika Grüneboom1,2, Ibrahim Hawwari1, Daniela Weidner2, Stephan Culemann2, Sylvia Müller3, Sophie Henneberg1, Alexandra Brenzel1, Simon Merz1, Lea Bornemann1, Kristina Zec1, Manuela Wuelling4, Lasse Kling5,6, Mike Hasenberg1, Sylvia Voortmann1, Stefanie Lang2, Wolfgang Baum2, Alexandra Ohs2, Oliver Kraff7, Harald H Quick7,8, Marcus Jäger9, Stefan Landgraeber9, Marcel Dudda9, Renzo Danuser10, Jens V Stein10, Manfred Rohde11, Kolja Gelse12, Annette I Garbe13, Alexandra Adamczyk14, Astrid M Westendorf14, Daniel Hoffmann15, Silke Christiansen5,6, Daniel Robert Engel1, Andrea Vortkamp4, Gerhard Krönke2, Martin Herrmann2, Thomas Kamradt3, Georg Schett2, Anja Hasenberg16, Matthias Gunzer17.
Abstract
Closed circulatory systems (CCS) underlie the function of vertebrate organs, but in long bones their structure is unclear, although they constitute the exit route for bone marrow (BM) leukocytes. To understand neutrophil emigration from BM, we studied the vascular system of murine long bones. Here we show that hundreds of capillaries originate in BM, cross murine cortical bone perpendicularly along the shaft and connect to the periosteal circulation. Structures similar to these trans-cortical-vessels (TCVs) also exist in human limb bones. TCVs express arterial or venous markers and transport neutrophils. Furthermore, over 80% arterial and 59% venous blood passes through TCVs. Genetic and drug-mediated modulation of osteoclast count and activity leads to substantial changes in TCV numbers. In a murine model of chronic arthritic bone inflammation, new TCVs develop within weeks. Our data indicate that TCVs are a central component of the CCS in long bones and may represent an important route for immune cell export from the BM.Entities:
Mesh：
Year: 2019 PMID： 31620676 PMCID： PMC6795552 DOI： 10.1038/s42255-018-0016-5
Source DB: PubMed Journal: Nat Metab ISSN： 2522-5812