Literature DB >> 32794081

Suicide: Genetics and Heritability.

Concepcion Vaquero-Lorenzo1, Manuel A Vasquez2.   

Abstract

Nature vs nurture is, and has been, a never stopping debate since Lamarck and Darwin exposed their corresponding theories on evolution, and even before them, such discussion already existed. Is suicide a heritable conduct? Is it learnt? Maybe the answer is both and none, at the same time. From genetic twin studies to epigenetic and environmental influence on development, this chapter aims to take a look at different points of view and most relevant theories in one of the worlds leading causes of death, specially for young individuals. We explore different studies aiming to find biomarkers for suicide, as well as other traits frequently encountered in individuals who engage in suicidal behavior, such as impulsivity, aggressivity, and hopelessness. Finally, this chapter also looks at some of the most recent approaches in treatment and prevention of suicidal behavior, in order to highlight what they have in common and try to explain (at least partially) why they could be effective.

Keywords:  Cognition; Environmental; Epigenetics; Heritability; Suicide

Year:  2020        PMID: 32794081     DOI: 10.1007/7854_2020_161

Source DB:  PubMed          Journal:  Curr Top Behav Neurosci        ISSN: 1866-3370


  35 in total

1.  The monoamine oxidase A gene may influence the means used in suicide attempts.

Authors:  Philippe Courtet; Fabrice Jollant; Catherine Buresi; Didier Castelnau; Dominique Mouthon; Alain Malafosse
Journal:  Psychiatr Genet       Date:  2005-09       Impact factor: 2.458

2.  Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.

Authors:  Brett A Clementz; John A Sweeney; Jordan P Hamm; Elena I Ivleva; Lauren E Ethridge; Godfrey D Pearlson; Matcheri S Keshavan; Carol A Tamminga
Journal:  Am J Psychiatry       Date:  2015-12-07       Impact factor: 18.112

Review 3.  BDNF - a key transducer of antidepressant effects.

Authors:  Carl Björkholm; Lisa M Monteggia
Journal:  Neuropharmacology       Date:  2015-11-11       Impact factor: 5.250

Review 4.  8-week Mindfulness Based Stress Reduction induces brain changes similar to traditional long-term meditation practice - A systematic review.

Authors:  Rinske A Gotink; Rozanna Meijboom; Meike W Vernooij; Marion Smits; M G Myriam Hunink
Journal:  Brain Cogn       Date:  2016-07-16       Impact factor: 2.310

Review 5.  Epigenetic mechanisms of stress and depression.

Authors:  Natalia Chmielewska; Janusz Szyndler; Piotr Maciejak; Adam Płaźnik
Journal:  Psychiatr Pol       Date:  2019-12-31       Impact factor: 1.657

Review 6.  Serotonergic genes and suicide: a systematic review.

Authors:  Niki Antypa; Alessandro Serretti; Dan Rujescu
Journal:  Eur Neuropsychopharmacol       Date:  2013-06-03       Impact factor: 4.600

7.  Epigenetic regulation of BDNF gene in response to stress.

Authors:  Manabu Fuchikami; Shigeto Yamamoto; Shigeru Morinobu; Shiro Takei; Shigeto Yamawaki
Journal:  Psychiatry Investig       Date:  2010-12-13       Impact factor: 2.505

Review 8.  Functional imaging, serotonin and the suicidal brain.

Authors:  K Audenaert; K Peremans; I Goethals; C van Heeringen
Journal:  Acta Neurol Belg       Date:  2006-09       Impact factor: 2.396

9.  Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.

Authors:  J Brezo; A Bureau; C Mérette; V Jomphe; E D Barker; F Vitaro; M Hébert; R Carbonneau; R E Tremblay; G Turecki
Journal:  Mol Psychiatry       Date:  2009-04-21       Impact factor: 15.992

10.  Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims.

Authors:  V Arango; M D Underwood; A V Gubbi; J J Mann
Journal:  Brain Res       Date:  1995-08-07       Impact factor: 3.252

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  2 in total

Review 1.  Suicide Biomarkers to Predict Risk, Classify Diagnostic Subtypes, and Identify Novel Therapeutic Targets: 5 Years of Promising Research.

Authors:  Jenessa N Johnston; Darcy Campbell; Hector J Caruncho; Ioline D Henter; Elizabeth D Ballard; Carlos A Zarate
Journal:  Int J Neuropsychopharmacol       Date:  2022-03-17       Impact factor: 5.176

2.  Genome-wide association study meta-analysis of suicide death and suicidal behavior.

Authors:  Qingqin S Li; Andrey A Shabalin; Emily DiBlasi; Srihari Gopal; Carla M Canuso; Aarno Palotie; Wayne C Drevets; Anna R Docherty; Hilary Coon
Journal:  Mol Psychiatry       Date:  2022-10-17       Impact factor: 13.437

  2 in total

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