Nikhil Singh1,2, Li Ding3, Gregory A Magee4, David M Shavelle5, Vikram S Kashyap6, Parveen K Garg5. 1. Section of Cardiology, Department of Medicine, University of Chicago, IL (N.S.). 2. Department of Internal Medicine (N.S.), University of Southern California Keck School of Medicine, Los Angeles. 3. Department of Preventive Medicine (L.D.), University of Southern California Keck School of Medicine, Los Angeles. 4. Division of Vascular Surgery and Endovascular Therapy (G.A.M.), University of Southern California Keck School of Medicine, Los Angeles. 5. Division of Cardiology (D.M.S., P.K.G.), University of Southern California Keck School of Medicine, Los Angeles. 6. Division of Vascular Surgery and Endovascular Therapy, University Hospitals Cleveland Medical Center, OH (V.S.K.).
Abstract
BACKGROUND: Despite current guidelines suggesting a benefit for dual antiplatelet therapy (DAPT) following peripheral vascular intervention (PVI), there are limited data on antiplatelet prescribing patterns post-procedure. We attempted to determine variables associated with DAPT prescription following lower extremity PVI. METHODS: Retrospective analysis of patients undergoing lower extremity PVI in the Vascular Quality Initiative (2017-2018) was performed. Participants not on anticoagulation or DAPT before the procedure were considered for the final analysis. Postdischarge antiplatelet therapy regimen rates were determined (none, aspirin only, P2Y12 inhibitor only, and DAPT). Multivariate logistic regression was performed to determine variables associated with DAPT initiation compared with those discharged on single-agent or no antiplatelet therapy. RESULTS: A total of 16 597 procedures were included for analysis, with 49% initiated on DAPT post-PVI. Male sex (odds ratio [OR], 1.12 [95% CI, 1.05-1.20]), smoking (OR, 1.20 [95% CI, 1.09-1.32]), and coronary artery disease (OR, 1.19 [95% CI, 1.11-1.27]) were associated with an increased likelihood of post-PVI DAPT prescription. Procedures requiring multiple types of interventions (OR, 1.28 [95% CI, 1.15-1.42]), stent placement (OR, 1.16 [95% CI, 1.06-1.27]), and with complications (OR, 1.31 [95% CI, 1.14-1.52]) were also positively associated with DAPT prescription. CONCLUSIONS: In patients not already receiving anticoagulation or on DAPT at the time of lower extremity PVI, prescription of DAPT following intervention is ≈50%. Multiple factors were associated with the decision for DAPT versus single antiplatelet therapy, and further study is required to understand how this affects postintervention adverse limb and cardiovascular events.
BACKGROUND: Despite current guidelines suggesting a benefit for dual antiplatelet therapy (DAPT) following peripheral vascular intervention (PVI), there are limited data on antiplatelet prescribing patterns post-procedure. We attempted to determine variables associated with DAPT prescription following lower extremity PVI. METHODS: Retrospective analysis of patients undergoing lower extremity PVI in the Vascular Quality Initiative (2017-2018) was performed. Participants not on anticoagulation or DAPT before the procedure were considered for the final analysis. Postdischarge antiplatelet therapy regimen rates were determined (none, aspirin only, P2Y12 inhibitor only, and DAPT). Multivariate logistic regression was performed to determine variables associated with DAPT initiation compared with those discharged on single-agent or no antiplatelet therapy. RESULTS: A total of 16 597 procedures were included for analysis, with 49% initiated on DAPT post-PVI. Male sex (odds ratio [OR], 1.12 [95% CI, 1.05-1.20]), smoking (OR, 1.20 [95% CI, 1.09-1.32]), and coronary artery disease (OR, 1.19 [95% CI, 1.11-1.27]) were associated with an increased likelihood of post-PVI DAPT prescription. Procedures requiring multiple types of interventions (OR, 1.28 [95% CI, 1.15-1.42]), stent placement (OR, 1.16 [95% CI, 1.06-1.27]), and with complications (OR, 1.31 [95% CI, 1.14-1.52]) were also positively associated with DAPT prescription. CONCLUSIONS: In patients not already receiving anticoagulation or on DAPT at the time of lower extremity PVI, prescription of DAPT following intervention is ≈50%. Multiple factors were associated with the decision for DAPT versus single antiplatelet therapy, and further study is required to understand how this affects postintervention adverse limb and cardiovascular events.
Authors: Sumeet Subherwal; Manesh R Patel; Lars Kober; Eric D Peterson; William S Jones; Gunnar H Gislason; Jeffrey Berger; Christian Torp-Pedersen; Emil L Fosbol Journal: Circulation Date: 2012-08-08 Impact factor: 29.690
Authors: Ae Jin Kim; Hye Jin Lim; Han Ro; Kwang-Pil Ko; Song Yi Han; Jae Hyun Chang; Hyun Hee Lee; Wookyung Chung; Ji Yong Jung Journal: PLoS One Date: 2014-08-05 Impact factor: 3.240