Literature DB >> 32783612

Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan.

Benjamin F Miller1,2,3, John P Thyfault4,5,6.   

Abstract

There is an increased focus on treatments to extend the healthspan. There is solid evidence that exercise extends the healthspan, but other treatments, such as metformin and statins, are also gaining traction. If metformin and statins will be used to prolong healthspan, we must understand their effects in those free of disease and in combination with exercise.

Entities:  

Keywords:  aerobic; mitochondria; pharmaceutical; treatment

Mesh：

Substances：

Year:  2020        PMID： 32783612      PMCID： PMC7642846          DOI： 10.1152/physiol.00013.2020

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  94 in total

Review 1.  The pharmacogenetics of metformin.

Authors:  Jose C Florez
Journal:  Diabetologia       Date:  2017-08-03       Impact factor: 10.122

2.  Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.

Authors:  B A Schick; R Laaksonen; J J Frohlich; H Päivä; T Lehtimäki; K H Humphries; H C F Côté
Journal:  Clin Pharmacol Ther       Date:  2007-02-28       Impact factor: 6.875

3.  2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

Authors:  Neil J Stone; Jennifer G Robinson; Alice H Lichtenstein; C Noel Bairey Merz; Conrad B Blum; Robert H Eckel; Anne C Goldberg; David Gordon; Daniel Levy; Donald M Lloyd-Jones; Patrick McBride; J Sanford Schwartz; Susan T Shero; Sidney C Smith; Karol Watson; Peter W F Wilson
Journal:  J Am Coll Cardiol       Date:  2013-11-12       Impact factor: 24.094

4.  Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients.

Authors:  Hitoshi Ando; Koh-Ichi Sugimoto; Hayato Yanagihara; Shuichi Tsuruoka; Tetsuo Saito; Toshinari Takamura; Shuichi Kaneko; Akio Fujimura
Journal:  Clin Exp Pharmacol Physiol       Date:  2008-04-21       Impact factor: 2.557

5.  Effect of metformin on exercise capacity: A meta-analysis.

Authors:  Saibal Das; Sapan Kumar Behera; Akila Srinivasan; Alphienes Stanley Xavier; Sandhiya Selvarajan; Sadishkumar Kamalanathan; Jaya Prakash Sahoo; N Sreekumaran Nair
Journal:  Diabetes Res Clin Pract       Date:  2018-09-12       Impact factor: 5.602

6.  Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk--the PIOSTAT Study.

Authors:  Thomas Forst; Andreas Pfützner; Georg Lübben; Matthias Weber; Nikolaus Marx; Efstrathios Karagiannis; Carsta Koehler; Werner Baurecht; Cloth Hohberg; Markolf Hanefeld
Journal:  Metabolism       Date:  2007-04       Impact factor: 8.694

7.  Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

Authors:  Marc Foretz; Sophie Hébrard; Jocelyne Leclerc; Elham Zarrinpashneh; Maud Soty; Gilles Mithieux; Kei Sakamoto; Fabrizio Andreelli; Benoit Viollet
Journal:  J Clin Invest       Date:  2010-06-23       Impact factor: 14.808

8.  Long-term metformin usage and cognitive function among older adults with diabetes.

Authors:  Tze Pin Ng; Liang Feng; Keng Bee Yap; Tih Shih Lee; Chay Hoon Tan; Bengt Winblad
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

9.  Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

Authors:  Tom J J Schirris; G Herma Renkema; Tina Ritschel; Nicol C Voermans; Albert Bilos; Baziel G M van Engelen; Ulrich Brandt; Werner J H Koopman; Julien D Beyrath; Richard J Rodenburg; Peter H G M Willems; Jan A M Smeitink; Frans G M Russel
Journal:  Cell Metab       Date:  2015-09-01       Impact factor: 27.287

Review 10.  Metformin and cognition from the perspectives of sex, age, and disease.

Authors:  Kiran Chaudhari; Conner D Reynolds; Shao-Hua Yang
Journal:  Geroscience       Date:  2020-01-02       Impact factor: 7.713
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  6 in total

1.  Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals.

Authors:  Douglas E Long; Kate Kosmac; Cory M Dungan; Marcas M Bamman; Charlotte A Peterson; Philip A Kern
Journal:  Front Physiol       Date:  2022-04-14       Impact factor: 4.755

2.  Metformin and tBHQ Treatment Combined with an Exercise Regime Prevents Osteosarcopenic Obesity in Middle-Aged Wistar Female Rats.

Authors:  Rafael Toledo-Pérez; Stefanie Paola Lopéz-Cervantes; David Hernández-Álvarez; Beatriz Mena-Montes; Gibran Pedraza-Vázquez; Carlos Sánchez-Garibay; Norma Edith López-Diazguerrero; Mina Königsberg; Armando Luna-López
Journal:  Oxid Med Cell Longev       Date:  2021-08-14       Impact factor: 6.543

3.  Effects of chronic metformin treatment on training adaptations in men and women with hyperglycemia: A prospective study.

Authors:  Alfonso Moreno-Cabañas; Felix Morales-Palomo; Laura Alvarez-Jimenez; Juan Fernando Ortega; Ricardo Mora-Rodriguez
Journal:  Obesity (Silver Spring)       Date:  2022-05-17       Impact factor: 9.298

4.  Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes.

Authors:  Nicolas J Pillon; Jonathon A B Smith; Petter S Alm; Alexander V Chibalin; Julia Alhusen; Erik Arner; Piero Carninci; Tomas Fritz; Julia Otten; Tommy Olsson; Sophie van Doorslaer de Ten Ryen; Louise Deldicque; Kenneth Caidahl; Harriet Wallberg-Henriksson; Anna Krook; Juleen R Zierath
Journal:  Sci Adv       Date:  2022-09-07       Impact factor: 14.957

5.  Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice.

Authors:  Yuan Zhang; Yuting Liu; Xiaowei Liu; Xinmeng Yuan; Mengqi Xiang; Jingjing Liu; Liumei Zhang; Shouqian Zhu; Jiao Lu; Qiang Tang; Sulin Cheng
Journal:  Oxid Med Cell Longev       Date:  2022-09-09       Impact factor: 7.310

6.  Physiology in Perspective: A Key Role of Physiology in Understanding COVID-19.

Authors:  Gary C Sieck
Journal:  Physiology (Bethesda)       Date:  2020-09-01
  6 in total

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