Literature DB >> 17329991

Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.

B A Schick1, R Laaksonen, J J Frohlich, H Päivä, T Lehtimäki, K H Humphries, H C F Côté.   

Abstract

Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.

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Year:  2007        PMID： 17329991     DOI： 10.1038/sj.clpt.6100124

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  31 in total

1.  Coenzyme Q(10) and statin myalgia: what is the evidence?

Authors:  Emilie Mas; Trevor A Mori
Journal:  Curr Atheroscler Rep       Date:  2010-11       Impact factor: 5.113

2.  Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration.

Authors:  Koji Nonaka; Yutaka Ozaki; Kenichi Ito; Masahiro Sakita; Satsuki Une; Junichi Akiyama
Journal:  J Physiol Sci       Date:  2018-12-08       Impact factor: 2.781

3.  An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells.

Authors:  Kathryn P Trogden; Rachel A Battaglia; Parijat Kabiraj; Victoria J Madden; Harald Herrmann; Natasha T Snider
Journal:  FASEB J       Date:  2018-01-18       Impact factor: 5.191

4.  Improvement in sleep apnoea associated with switch from simvastatin to pravastatin.

Authors:  Stephanie Cham; Komaldeep Gill; Sabrina Koperski; Beatrice Alexandra Golomb
Journal:  BMJ Case Rep       Date:  2009-09-01

Review 5.  The effects of statin medications on aerobic exercise capacity and training adaptations.

Authors:  Zsolt Murlasits; Zsolt Radák
Journal:  Sports Med       Date:  2014-11       Impact factor: 11.136

Review 6.  Modulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacology.

Authors:  Jerzy Bełtowski; Anna Jamroz-Wiśniewska
Journal:  Antioxid Redox Signal       Date:  2011-12-19       Impact factor: 8.401

7.  Evaluation of skeletal muscle during calf exercise by 31-phosphorus magnetic resonance spectroscopy in patients on statin medications.

Authors:  Jim S Wu; Catherine Buettner; Howard Smithline; Long H Ngo; Robert L Greenman
Journal:  Muscle Nerve       Date:  2011-01       Impact factor: 3.217

8.  Simvastatin impairs exercise training adaptations.

Authors:  Catherine R Mikus; Leryn J Boyle; Sarah J Borengasser; Douglas J Oberlin; Scott P Naples; Justin Fletcher; Grace M Meers; Meghan Ruebel; M Harold Laughlin; Kevin C Dellsperger; Paul J Fadel; John P Thyfault
Journal:  J Am Coll Cardiol       Date:  2013-04-10       Impact factor: 24.094

9.  Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications.

Authors:  J Wong; S V McLennan; L Molyneaux; D Min; S M Twigg; D K Yue
Journal:  Diabetologia       Date:  2009-07-21       Impact factor: 10.122

10.  High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults.

Authors:  Tinna Traustadóttir; Anthoney A Stock; S Mitchell Harman
Journal:  Age (Dordr)       Date:  2008-08-21
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