Puneyavee Aikphaibul1, Tuangtip Theerawit2, Jiratchaya Sophonphan3, Noppadol Wacharachaisurapol2,4, Nattapong Jitrungruengnij2, Thanyawee Puthanakit1,2. 1. Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. 2. Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. 3. The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand. 4. Clinical Pharmacokinetics and Pharmacogenomics Research Unit, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Abstract
AIM: To determine factors associated with severe hospitalized Respiratory syncytial virus (RSV)-associated LRTI and to describe management in tertiary care center. METHODS: Retrospective medical record review was conducted among children under 5 years old hospitalized with RSV-associated LRTI at King Chulalongkorn Memorial Hospital. Severe RSV-associated LRTI was defined as death, mechanical ventilator, or positive pressure ventilation use, prolonged hospitalization >7 days. Factors associated with severe RSV were analyzed using univariate and multivariate logistic regression. RESULTS: From January 2011 to December 2016, 427 children were hospitalized. Median age was 10 months (IQR 4.2-23.0). One hundred seventy-four (41%) patients had severe RSV (11 deaths, 56 mechanical ventilators, 19 positive pressure ventilation, and 88 prolonged hospitalization). Factors associated with severe RSV were chronic lung disease (aOR 15.16 [4.26-53.91]), cirrhosis/biliary atresia (aOR 15.01 [3.21-70.32]), congenital heart disease (aOR 5.11 [1.97-13.23]), chemotherapy (aOR 4.7 [1.34-16.56]), and pre-term (aOR 2.03 [1.13-3.67]). Oxygen therapy was mainly low flow oxygen delivery. 88% of cases received bronchodilator. Parenteral antibiotics were prescribed in 37.9% of cases. CONCLUSIONS: Children with co-morbidities have higher risk of severe RSV-associated LRTI. More than two-third of patients received bronchodilator, of which was not recommended by American Academy of Pediatrics. The specific treatment and prevention for RSV are urgently needed.
AIM: To determine factors associated with severe hospitalized Respiratory syncytial virus (RSV)-associated LRTI and to describe management in tertiary care center. METHODS: Retrospective medical record review was conducted among children under 5 years old hospitalized with RSV-associated LRTI at King Chulalongkorn Memorial Hospital. Severe RSV-associated LRTI was defined as death, mechanical ventilator, or positive pressure ventilation use, prolonged hospitalization >7 days. Factors associated with severe RSV were analyzed using univariate and multivariate logistic regression. RESULTS: From January 2011 to December 2016, 427 children were hospitalized. Median age was 10 months (IQR 4.2-23.0). One hundred seventy-four (41%) patients had severe RSV (11 deaths, 56 mechanical ventilators, 19 positive pressure ventilation, and 88 prolonged hospitalization). Factors associated with severe RSV were chronic lung disease (aOR 15.16 [4.26-53.91]), cirrhosis/biliary atresia (aOR 15.01 [3.21-70.32]), congenital heart disease (aOR 5.11 [1.97-13.23]), chemotherapy (aOR 4.7 [1.34-16.56]), and pre-term (aOR 2.03 [1.13-3.67]). Oxygen therapy was mainly low flow oxygen delivery. 88% of cases received bronchodilator. Parenteral antibiotics were prescribed in 37.9% of cases. CONCLUSIONS:Children with co-morbidities have higher risk of severe RSV-associated LRTI. More than two-third of patients received bronchodilator, of which was not recommended by American Academy of Pediatrics. The specific treatment and prevention for RSV are urgently needed.
Authors: Sarah Geoghegan; Anabella Erviti; Mauricio T Caballero; Fernando Vallone; Stella M Zanone; Juan Ves Losada; Alejandra Bianchi; Patricio L Acosta; Laura B Talarico; Adrian Ferretti; Luciano Alva Grimaldi; Andrea Sancilio; Karina Dueñas; Gustavo Sastre; Andrea Rodriguez; Fernando Ferrero; Edgar Barboza; Guadalupe Fernández Gago; Celina Nocito; Edgardo Flamenco; Alberto Rodriguez Perez; Beatriz Rebec; F Martin Ferolla; Romina Libster; Ruth A Karron; Eduardo Bergel; Fernando P Polack Journal: Am J Respir Crit Care Med Date: 2017-01-01 Impact factor: 21.405
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Authors: Ricardo Wesley Alberca; Júlia Cataldo Lima; Emily Araujo de Oliveira; Sarah Cristina Gozzi-Silva; Yasmim Álefe Leuzzi Ramos; Milena Mary de Souza Andrade; Danielle Rosa Beserra; Luana de Mendonça Oliveira; Anna Cláudia Calvielli Castelo Branco; Anna Julia Pietrobon; Nátalli Zanete Pereira; Franciane Mouradian Emidio Teixeira; Iara Grigoletto Fernandes; Alberto José da Silva Duarte; Gil Benard; Maria Notomi Sato Journal: Front Physiol Date: 2021-01-27 Impact factor: 4.566