Hossein Sanjari Moghaddam1, Mohammad Hadi Aarabi1, Jafar Mehvari-Habibabadi2, Roya Sharifpour3,4, Bahram Mohajer5, Neda Mohammadi-Mobarakeh3,4, Seyed Sohrab Hashemi-Fesharaki6, Kost Elisevich7, Mohammad-Reza Nazem-Zadeh8,9. 1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2. Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 4. Research Center for Molecular and Cellular Imaging, Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 5. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 6. Pars Advanced Medical Research Center, Pars Hospital, Tehran, Iran. 7. Department of Clinical Neurosciences, Spectrum Health, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA. 8. Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences (TUMS), Tehran, Iran. mnazemzadeh@tums.ac.ir. 9. Research Center for Molecular and Cellular Imaging, Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran. mnazemzadeh@tums.ac.ir.
Abstract
OBJECTIVE: To investigate the pattern and severity of hippocampal subfield volume loss in patients with left and right mesial temporal lobe epilepsy (mTLE) using quantitative MRI volumetric analysis. METHODS: A total of 21 left and 14 right mTLE subjects, as well as 15 healthy controls, were enrolled in this cross-sectional study. A publically available magnetic resonance imaging (MRI) brain volumetry system (volBrain) was used for volumetric analysis of hippocampal subfields. The T1-weighted images were processed with a HIPS pipeline. RESULTS: A distinct pattern of hippocampal subfield atrophy was found between left and right mTLE patients when compared with controls. Patients with left mTLE exhibited ipsilateral hippocampal atrophy and segmental volume depletion of the Cornu Ammonis (CA) 2/CA3, CA4/dentate gyrus (DG), and strata radiatum-lacunosum-moleculare (SR-SL-SM). Those with right mTLE exhibited similar ipsilateral hippocampal atrophy but with additional segmental CA1 volume depletion. More extensive bilateral subfield volume loss was apparent with right mTLE patients. CONCLUSION: We demonstrate that left and right mTLE patients show a dissimilar pattern of hippocampal subfield atrophy, suggesting the pathophysiology of epileptogenesis in left and right mTLE to be different.
OBJECTIVE: To investigate the pattern and severity of hippocampal subfield volume loss in patients with left and right mesial temporal lobe epilepsy (mTLE) using quantitative MRI volumetric analysis. METHODS: A total of 21 left and 14 right mTLE subjects, as well as 15 healthy controls, were enrolled in this cross-sectional study. A publically available magnetic resonance imaging (MRI) brain volumetry system (volBrain) was used for volumetric analysis of hippocampal subfields. The T1-weighted images were processed with a HIPS pipeline. RESULTS: A distinct pattern of hippocampal subfield atrophy was found between left and right mTLE patients when compared with controls. Patients with left mTLE exhibited ipsilateral hippocampal atrophy and segmental volume depletion of the Cornu Ammonis (CA) 2/CA3, CA4/dentate gyrus (DG), and strata radiatum-lacunosum-moleculare (SR-SL-SM). Those with right mTLE exhibited similar ipsilateral hippocampal atrophy but with additional segmental CA1 volume depletion. More extensive bilateral subfield volume loss was apparent with right mTLE patients. CONCLUSION: We demonstrate that left and right mTLE patients show a dissimilar pattern of hippocampal subfield atrophy, suggesting the pathophysiology of epileptogenesis in left and right mTLE to be different.
Entities:
Keywords:
Epilepsy; Hippocampus; Magnetic resonance imaging; Temporal lobe
Authors: Nobuko Kemmotsu; Holly M Girard; Boris C Bernhardt; Leonardo Bonilha; Jack J Lin; Evelyn S Tecoma; Vicente J Iragui; Donald J Hagler; Eric Halgren; Carrie R McDonald Journal: Epilepsia Date: 2011-10-05 Impact factor: 5.864
Authors: Susanne G Mueller; Kenneth D Laxer; Cathy Scanlon; Paul Garcia; William J McMullen; David W Loring; Kimford J Meador; Michael W Weiner Journal: Hum Brain Mapp Date: 2011-03-24 Impact factor: 5.038
Authors: Christopher D Whelan; Andre Altmann; Juan A Botía; Neda Jahanshad; Derrek P Hibar; Julie Absil; Saud Alhusaini; Marina K M Alvim; Pia Auvinen; Emanuele Bartolini; Felipe P G Bergo; Tauana Bernardes; Karen Blackmon; Barbara Braga; Maria Eugenia Caligiuri; Anna Calvo; Sarah J Carr; Jian Chen; Shuai Chen; Andrea Cherubini; Philippe David; Martin Domin; Sonya Foley; Wendy França; Gerrit Haaker; Dmitry Isaev; Simon S Keller; Raviteja Kotikalapudi; Magdalena A Kowalczyk; Ruben Kuzniecky; Soenke Langner; Matteo Lenge; Kelly M Leyden; Min Liu; Richard Q Loi; Pascal Martin; Mario Mascalchi; Marcia E Morita; Jose C Pariente; Raul Rodríguez-Cruces; Christian Rummel; Taavi Saavalainen; Mira K Semmelroch; Mariasavina Severino; Rhys H Thomas; Manuela Tondelli; Domenico Tortora; Anna Elisabetta Vaudano; Lucy Vivash; Felix von Podewils; Jan Wagner; Bernd Weber; Yi Yao; Clarissa L Yasuda; Guohao Zhang; Nuria Bargalló; Benjamin Bender; Neda Bernasconi; Andrea Bernasconi; Boris C Bernhardt; Ingmar Blümcke; Chad Carlson; Gianpiero L Cavalleri; Fernando Cendes; Luis Concha; Norman Delanty; Chantal Depondt; Orrin Devinsky; Colin P Doherty; Niels K Focke; Antonio Gambardella; Renzo Guerrini; Khalid Hamandi; Graeme D Jackson; Reetta Kälviäinen; Peter Kochunov; Patrick Kwan; Angelo Labate; Carrie R McDonald; Stefano Meletti; Terence J O'Brien; Sebastien Ourselin; Mark P Richardson; Pasquale Striano; Thomas Thesen; Roland Wiest; Junsong Zhang; Annamaria Vezzani; Mina Ryten; Paul M Thompson; Sanjay M Sisodiya Journal: Brain Date: 2018-02-01 Impact factor: 13.501
Authors: Magdalena Maria Woźniak; Monika Zbroja; Małgorzata Matuszek; Olga Pustelniak; Weronika Cyranka; Katarzyna Drelich; Ewa Kopyto; Andrzej Materniak; Tomasz Słomka; Maciej Cebula; Agnieszka Brodzisz Journal: J Clin Med Date: 2022-08-09 Impact factor: 4.964