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Literature DB >> 32777646

Uncorking MCU to let the calcium flow.

Abstract

New cryo-electron microscopy structures of the mitochondrial Ca2+ uniporter ion channel complex in various conformations reveal channel gating regulation by Ca2+-dependent unblock of the channel pore by MICU1.

Entities: Chemical Gene

Keywords: Cryo-EM; EMRE; Ion channel; MCU; MICU1; Mitochondria; Structure

Mesh：

Substances：

Year: 2020 PMID： 32777646 PMCID： PMC7530084 DOI： 10.1016/j.ceca.2020.102257

Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817

8 in total

1. Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca²⁺ uptake.

Authors: Horia Vais; Riley Payne; Usha Paudel; Carmen Li; J Kevin Foskett
Journal: Proc Natl Acad Sci U S A Date: 2020-08-14 Impact factor: 11.205

2. MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

Authors: György Csordás; Tünde Golenár; Erin L Seifert; Kimberli J Kamer; Yasemin Sancak; Fabiana Perocchi; Cynthia Moffat; David Weaver; Sergio de la Fuente Perez; Roman Bogorad; Victor Koteliansky; Jeffrey Adijanto; Vamsi K Mootha; György Hajnóczky
Journal: Cell Metab Date: 2013-06-04 Impact factor: 27.287

3. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Authors: Karthik Mallilankaraman; Patrick Doonan; César Cárdenas; Harish C Chandramoorthy; Marioly Müller; Russell Miller; Nicholas E Hoffman; Rajesh Kumar Gandhirajan; Jordi Molgó; Morris J Birnbaum; Brad S Rothberg; Don-On Daniel Mak; J Kevin Foskett; Muniswamy Madesh
Journal: Cell Date: 2012-10-26 Impact factor: 41.582

1 in total

Review 1. Calcium signaling in neurodevelopment and pathophysiology of autism spectrum disorders.

Authors: Ashkan Pourtavakoli; Soudeh Ghafouri-Fard
Journal: Mol Biol Rep Date: 2022-07-20 Impact factor: 2.742

1 in total

Uncorking MCU to let the calcium flow.

1. Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca²⁺ uptake.

2. MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

3. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

4. Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter.

5. Structure and mechanism of the mitochondrial Ca²⁺ uniporter holocomplex.

6. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.

7. Variable Assembly of EMRE and MCU Creates Functional Channels with Distinct Gatekeeping Profiles.

8. Voltage-energized Calcium-sensitive ATP Production by Mitochondria.

Review 1. Calcium signaling in neurodevelopment and pathophysiology of autism spectrum disorders.