Hans Scherübl1. 1. Klinik für Innere Medizin II, Gastroenterologie, GI Onkologie und Infektiologie, Klinikum Am Urban, Vivantes Netzwerk für Gesundheit, Berlin, Germany.
Abstract
BACKGROUND: Alcohol use is an important and potentially modifiable risk factor for gastrointestinal cancers. The more and the longer a person drinks, the higher the risk of cancer becomes. Even modest use of alcohol may increase cancer risk; 100 g of alcohol per week or less is currently considered to be the limit of low-risk use. GASTROINTESTINAL CANCER RISK: Alcohol is causally associated with oesophageal squamous cell cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, and most likely also with pancreatic cancer. Alcohol when combined with tobacco smoking or excess body weight can act synergistically to cause gastrointestinal cancer. Exposure to alcohol may have contributed to the recent incidence increases of early-onset gastrointestinal cancers in some Western countries. CONCLUSIONS: People with long-term risky alcohol use should be encouraged to join cancer screening programmes. Alcohol cessation appears to be effective in reducing the alcohol-induced, increased cancer risk.
BACKGROUND: Alcohol use is an important and potentially modifiable risk factor for gastrointestinal cancers. The more and the longer a person drinks, the higher the risk of cancer becomes. Even modest use of alcohol may increase cancer risk; 100 g of alcohol per week or less is currently considered to be the limit of low-risk use. GASTROINTESTINAL CANCER RISK: Alcohol is causally associated with oesophageal squamous cell cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, and most likely also with pancreatic cancer. Alcohol when combined with tobacco smoking or excess body weight can act synergistically to cause gastrointestinal cancer. Exposure to alcohol may have contributed to the recent incidence increases of early-onset gastrointestinal cancers in some Western countries. CONCLUSIONS: People with long-term risky alcohol use should be encouraged to join cancer screening programmes. Alcohol cessation appears to be effective in reducing the alcohol-induced, increased cancer risk.
Authors: Enrique Rodríguez-de-Santiago; Nerea Hernanz; Héctor Miguel Marcos-Prieto; Miguel Ángel de Jorge-Turrión; Eva Barreiro-Alonso; Carlos Rodríguez-Escaja; Andrea Jiménez-Jurado; Nadja Machado-Volpato; Isabel Pérez-Valle; María García-Prada; María Sierra-Morales; Raquel Ríos León; Laura Núñez Gómez; Ana García García-de-Paredes; Andrés Castaño-García; José Ramón Foruny-Olcina; Beatriz Peñas-García; Enrique Vázquez-Sequeiros; Agustín Albillos Journal: Gastroenterol Hepatol Date: 2019-09-10 Impact factor: 2.102
Authors: Nils Homann; Felix Stickel; Inke R König; Arne Jacobs; Klaus Junghanns; Monika Benesova; Detlef Schuppan; Susanne Himsel; Ina Zuber-Jerger; Claus Hellerbrand; Dieter Ludwig; Wolfgang H Caselmann; Helmut K Seitz Journal: Int J Cancer Date: 2006-04-15 Impact factor: 7.396
Authors: Mario Rueda; Yara Robertson; Alison Acott; Steven Rueda; Aaron Keikhoff; Whitney Guerrero; Anne T Mancino Journal: Am J Surg Date: 2012-10-04 Impact factor: 2.565
Authors: Angela M Wood; Stephen Kaptoge; Adam S Butterworth; Peter Willeit; Samantha Warnakula; Thomas Bolton; Ellie Paige; Dirk S Paul; Michael Sweeting; Stephen Burgess; Steven Bell; William Astle; David Stevens; Albert Koulman; Randi M Selmer; W M Monique Verschuren; Shinichi Sato; Inger Njølstad; Mark Woodward; Veikko Salomaa; Børge G Nordestgaard; Bu B Yeap; Astrid Fletcher; Olle Melander; Lewis H Kuller; Beverley Balkau; Michael Marmot; Wolfgang Koenig; Edoardo Casiglia; Cyrus Cooper; Volker Arndt; Oscar H Franco; Patrik Wennberg; John Gallacher; Agustín Gómez de la Cámara; Henry Völzke; Christina C Dahm; Caroline E Dale; Manuela M Bergmann; Carlos J Crespo; Yvonne T van der Schouw; Rudolf Kaaks; Leon A Simons; Pagona Lagiou; Josje D Schoufour; Jolanda M A Boer; Timothy J Key; Beatriz Rodriguez; Conchi Moreno-Iribas; Karina W Davidson; James O Taylor; Carlotta Sacerdote; Robert B Wallace; J Ramon Quiros; Rosario Tumino; Dan G Blazer; Allan Linneberg; Makoto Daimon; Salvatore Panico; Barbara Howard; Guri Skeie; Timo Strandberg; Elisabete Weiderpass; Paul J Nietert; Bruce M Psaty; Daan Kromhout; Elena Salamanca-Fernandez; Stefan Kiechl; Harlan M Krumholz; Sara Grioni; Domenico Palli; José M Huerta; Jackie Price; Johan Sundström; Larraitz Arriola; Hisatomi Arima; Ruth C Travis; Demosthenes B Panagiotakos; Anna Karakatsani; Antonia Trichopoulou; Tilman Kühn; Diederick E Grobbee; Elizabeth Barrett-Connor; Natasja van Schoor; Heiner Boeing; Kim Overvad; Jussi Kauhanen; Nick Wareham; Claudia Langenberg; Nita Forouhi; Maria Wennberg; Jean-Pierre Després; Mary Cushman; Jackie A Cooper; Carlos J Rodriguez; Masaru Sakurai; Jonathan E Shaw; Matthew Knuiman; Trudy Voortman; Christa Meisinger; Anne Tjønneland; Hermann Brenner; Luigi Palmieri; Jean Dallongeville; Eric J Brunner; Gerd Assmann; Maurizio Trevisan; Richard F Gillum; Ian Ford; Naveed Sattar; Mariana Lazo; Simon G Thompson; Pietro Ferrari; David A Leon; George Davey Smith; Richard Peto; Rod Jackson; Emily Banks; Emanuele Di Angelantonio; John Danesh Journal: Lancet Date: 2018-04-14 Impact factor: 202.731
Authors: Alina Maria Mehedinţeanu; Cecil Sorin Mirea; Puiu Olivian Stovicek; Michael Schenker; Marius Ionuţ Stancu; Ana Maria Ciurea; Liliana Streba; Anca Maria Istrate-Ofiţeru; Teodor Nicuşor Sas; Cristin Constantin Vere Journal: Rom J Morphol Embryol Date: 2021 Oct-Dec Impact factor: 0.833
Authors: Michael B Yan; Haig Pakhchanian; Rahul Raiker; Osama Boustany; Ahmad Khan; Shailendra Singh Journal: Environ Sci Pollut Res Int Date: 2022-06-15 Impact factor: 5.190