Hallie C Prescott1,2, Jeremy B Sussman1,2, W Joost Wiersinga3,4. 1. Department of Internal Medicine, University of Michigan. 2. VA Center for Clinical Management Research, Ann Arbor, Michigan, USA. 3. Department of Medicine, Division of Infectious Diseases. 4. Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Abstract
PURPOSE OF REVIEW: Critical illness survivorship is associated with new and worsening physical, cognitive, and emotional status. Survivors are vulnerable to further health set-backs, most commonly because of infection and exacerbation of chronic medical conditions. Awareness of survivors' challenges are important given the anticipated rise in critical illness survivors because of SARS-CoV-2 viral sepsis. RECENT FINDINGS: Studies continue to document challenges of critical illness survivorship. Beyond the cognitive, physical, and mental health sequelae encompassed by postintensive case syndrome, patients commonly experience persistent immunosuppression, re-hospitalization, inability to resume prior employment, and reduced quality of life. Although recommended practices for enhancing recovery from sepsis are associated with better outcomes, only a minority of patients receive all recommended practices. ICU follow-up programs or peer support groups remain important interventions to learn about and address the multifaceted challenges of critical illness survivorship, but there is little evidence of benefit to date. SUMMARY: Survivors of sepsis and critical illness commonly experience impaired health status, reduced quality of life, and inability to return to prior employment. Although the challenges of critical illness survivorship are increasingly well documented, there are relatively few studies on enhancing recovery. Future studies must focus on identifying best practices for optimizing recovery and strategies to promote their implementation.
PURPOSE OF REVIEW: Critical illness survivorship is associated with new and worsening physical, cognitive, and emotional status. Survivors are vulnerable to further health set-backs, most commonly because of infection and exacerbation of chronic medical conditions. Awareness of survivors' challenges are important given the anticipated rise in critical illness survivors because of SARS-CoV-2 viral sepsis. RECENT FINDINGS: Studies continue to document challenges of critical illness survivorship. Beyond the cognitive, physical, and mental health sequelae encompassed by postintensive case syndrome, patients commonly experience persistent immunosuppression, re-hospitalization, inability to resume prior employment, and reduced quality of life. Although recommended practices for enhancing recovery from sepsis are associated with better outcomes, only a minority of patients receive all recommended practices. ICU follow-up programs or peer support groups remain important interventions to learn about and address the multifaceted challenges of critical illness survivorship, but there is little evidence of benefit to date. SUMMARY: Survivors of sepsis and critical illness commonly experience impaired health status, reduced quality of life, and inability to return to prior employment. Although the challenges of critical illness survivorship are increasingly well documented, there are relatively few studies on enhancing recovery. Future studies must focus on identifying best practices for optimizing recovery and strategies to promote their implementation.
Authors: Hugo Perazzo; Sandra W Cardoso; Maria Pia D Ribeiro; Rodrigo Moreira; Lara E Coelho; Emilia M Jalil; André Miguel Japiassú; Elias Pimentel Gouvêa; Estevão Portela Nunes; Hugo Boechat Andrade; Luciano Barros Gouvêa; Marcel Treptow Ferreira; Pedro Mendes de Azambuja Rodrigues; Ronaldo Moreira; Kim Geraldo; Lucilene Freitas; Vinicius V Pacheco; Esau Custódio João; Trevon Fuller; Verônica Diniz Rocha; Ceuci de Lima Xavier Nunes; Tâmara Newman Lobato Souza; Ana Luiza Castro Conde Toscano; Alexandre Vargas Schwarzbold; Helena Carolina Noal; Gustavo de Araujo Pinto; Paula Macedo de Oliveira Lemos; Carla Santos; Fernanda Carvalho de Queiroz Mello; Valdilea G Veloso; Beatriz Grinsztejn Journal: Lancet Reg Health Am Date: 2022-04-12