| Literature DB >> 32772049 |
Hayato Tada1, Noboru Fujino2, Akihiro Nomura2, Chiaki Nakanishi2, Kenshi Hayashi2, Masayuki Takamura2, Masa-Aki Kawashiri2.
Abstract
Personalized medicine is an emerging concept involving managing the health of patients based on their individual characteristics, including particular genotypes. Cardiovascular diseases are heritable traits, and family history information is useful for risk prediction. As such, determining genetic information (germline genetic mutations) may also be applied to risk prediction. Furthermore, accumulating evidence suggests that genetic background can provide guidance for selecting effective treatments and preventive strategies in individuals with particular genotypes. These concepts may be applicable both to rare Mendelian diseases and to common complex traits. In this review, we define the concept and provide examples of personalized medicine based on human genetics for cardiovascular diseases, including coronary artery disease, arrhythmia, and cardiomyopathies. We also provide a particular focus on Mendelian randomization studies, especially those examining loss-of function genetic variations, for identifying high-risk individuals, as well as signaling pathways that may be useful targets for improving healthy living without cardiovascular events.Entities:
Mesh：
Year: 2020 PMID： 32772049 DOI： 10.1038/s10038-020-0818-7
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172