Literature DB >> 32763223

TDP-43 Nuclear Bodies: A NEAT Response to Stress?

Ahmed M Malik1, Sami J Barmada2.   

Abstract

In this issue of Molecular Cell, Wang et al. (2020) investigate stress-induced nuclear condensates of the RNA-binding protein TDP-43, uncovering a protective function for these granules as well as an RNA-dependent mechanism for scaffolding them.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 32763223      PMCID： PMC8288078          DOI： 10.1016/j.molcel.2020.07.018

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  Higher order arrangement of the eukaryotic nuclear bodies.

Authors:  I-Fan Wang; Narsa M Reddy; C-K James Shen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-02       Impact factor: 11.205

2.  Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation.

Authors:  Chen Wang; Yongjia Duan; Gang Duan; Qiangqiang Wang; Kai Zhang; Xue Deng; Beituo Qian; Jinge Gu; Zhiwei Ma; Shuang Zhang; Lin Guo; Cong Liu; Yanshan Fang
Journal:  Mol Cell       Date:  2020-07-03       Impact factor: 17.970

3.  Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.

Authors:  Maria Udan-Johns; Rocio Bengoechea; Shaughn Bell; Jieya Shao; Marc I Diamond; Heather L True; Conrad C Weihl; Robert H Baloh
Journal:  Hum Mol Genet       Date:  2013-08-19       Impact factor: 6.150

4.  RNA buffers the phase separation behavior of prion-like RNA binding proteins.

Authors:  Shovamayee Maharana; Jie Wang; Dimitrios K Papadopoulos; Doris Richter; Andrey Pozniakovsky; Ina Poser; Marc Bickle; Sandra Rizk; Jordina Guillén-Boixet; Titus M Franzmann; Marcus Jahnel; Lara Marrone; Young-Tae Chang; Jared Sterneckert; Pavel Tomancak; Anthony A Hyman; Simon Alberti
Journal:  Science       Date:  2018-04-12       Impact factor: 47.728

5.  The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.

Authors:  Yoshinori Nishimoto; Shinichi Nakagawa; Tetsuro Hirose; Hirotaka James Okano; Masaki Takao; Shinsuke Shibata; Satoshi Suyama; Ken-Ichiro Kuwako; Takao Imai; Shigeo Murayama; Norihiro Suzuki; Hideyuki Okano
Journal:  Mol Brain       Date:  2013-07-08       Impact factor: 4.041

6.  Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization.

Authors:  Emile S Pinarbasi; Tolga Cağatay; Ho Yee Joyce Fung; Ying C Li; Yuh Min Chook; Philip J Thomas
Journal:  Sci Rep       Date:  2018-05-04       Impact factor: 4.379

7.  Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition.

Authors:  Miha Modic; Markus Grosch; Gregor Rot; Silvia Schirge; Tjasa Lepko; Tomohiro Yamazaki; Flora C Y Lee; Ejona Rusha; Dmitry Shaposhnikov; Michael Palo; Juliane Merl-Pham; Davide Cacchiarelli; Boris Rogelj; Stefanie M Hauck; Christian von Mering; Alexander Meissner; Heiko Lickert; Tetsuro Hirose; Jernej Ule; Micha Drukker
Journal:  Mol Cell       Date:  2019-04-29       Impact factor: 17.970

8.  An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration.

Authors:  Brittany N Flores; Xingli Li; Ahmed M Malik; Jose Martinez; Asim A Beg; Sami J Barmada
Journal:  Cell Rep       Date:  2019-04-23       Impact factor: 9.423

9.  Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.

Authors:  Helena Ederle; Christina Funk; Claudia Abou-Ajram; Saskia Hutten; Eva B E Funk; Ralph H Kehlenbach; Susanne M Bailer; Dorothee Dormann
Journal:  Sci Rep       Date:  2018-05-04       Impact factor: 4.379

10.  ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles.

Authors:  Haiyan An; Lucy Skelt; Antonietta Notaro; J Robin Highley; Archa H Fox; Vincenzo La Bella; Vladimir L Buchman; Tatyana A Shelkovnikova
Journal:  Acta Neuropathol Commun       Date:  2019-01-14       Impact factor: 7.578
  10 in total
  1 in total

Review 1.  The Integral Role of RNA in Stress Granule Formation and Function.

Authors:  Danae Campos-Melo; Zachary C E Hawley; Cristian A Droppelmann; Michael J Strong
Journal:  Front Cell Dev Biol       Date:  2021-05-20
  1 in total

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