Literature DB >> 32763179

A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity.

Joey H Li1, Yvonne Y Chen2.   

Abstract

Senescence is a critical factor in several diseases, yet senolytic therapies targeting senescent cells remain hindered by lack of specificity. In the June issue of Nature, Amor et al. (2020) develop chimeric antigen receptor (CAR)-T cells targeting uPAR, a novel senescent-cell marker, to treat liver adenocarcinoma and liver fibrosis.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 32763179      PMCID： PMC7717659          DOI： 10.1016/j.stem.2020.07.010

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

Review 1.  CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date.

Authors:  Jae H Park; Mark B Geyer; Renier J Brentjens
Journal:  Blood       Date:  2016-05-20       Impact factor: 22.113

2.  A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy.

Authors:  Steven G Deeks; Bridget Wagner; Peter A Anton; Ronald T Mitsuyasu; David T Scadden; Christine Huang; Catherine Macken; Douglas D Richman; Cindy Christopherson; Carl H June; Richard Lazar; David F Broad; Sayeh Jalali; Kristen M Hege
Journal:  Mol Ther       Date:  2002-06       Impact factor: 11.454

3.  Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer.

Authors:  Charles M Rudin; Christine L Hann; Edward B Garon; Moacyr Ribeiro de Oliveira; Philip D Bonomi; D Ross Camidge; Quincy Chu; Giuseppe Giaccone; Divis Khaira; Suresh S Ramalingam; Malcolm R Ranson; Caroline Dive; Evelyn M McKeegan; Brenda J Chyla; Barry L Dowell; Arunava Chakravartty; Cathy E Nolan; Niki Rudersdorf; Todd A Busman; Mack H Mabry; Andrew P Krivoshik; Rod A Humerickhouse; Geoffrey I Shapiro; Leena Gandhi
Journal:  Clin Cancer Res       Date:  2012-04-11       Impact factor: 12.531

Review 4.  Senescent cells: an emerging target for diseases of ageing.

Authors:  Bennett G Childs; Martina Gluscevic; Darren J Baker; Remi-Martin Laberge; Dan Marquess; Jamie Dananberg; Jan M van Deursen
Journal:  Nat Rev Drug Discov       Date:  2017-07-21       Impact factor: 84.694

5.  Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

Authors:  Jianhui Chang; Yingying Wang; Lijian Shao; Remi-Martin Laberge; Marco Demaria; Judith Campisi; Krishnamurthy Janakiraman; Norman E Sharpless; Sheng Ding; Wei Feng; Yi Luo; Xiaoyan Wang; Nukhet Aykin-Burns; Kimberly Krager; Usha Ponnappan; Martin Hauer-Jensen; Aimin Meng; Daohong Zhou
Journal:  Nat Med       Date:  2015-12-14       Impact factor: 53.440

6.  Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease.

Authors:  Christoph T Ellebrecht; Vijay G Bhoj; Arben Nace; Eun Jung Choi; Xuming Mao; Michael Jeffrey Cho; Giovanni Di Zenzo; Antonio Lanzavecchia; John T Seykora; George Cotsarelis; Michael C Milone; Aimee S Payne
Journal:  Science       Date:  2016-06-30       Impact factor: 47.728

7.  Targeting cardiac fibrosis with engineered T cells.

Authors:  Haig Aghajanian; Toru Kimura; Joel G Rurik; Aidan S Hancock; Michael S Leibowitz; Li Li; John Scholler; James Monslow; Albert Lo; Wei Han; Tao Wang; Kenneth Bedi; Michael P Morley; Ricardo A Linares Saldana; Nikhita A Bolar; Kendra McDaid; Charles-Antoine Assenmacher; Cheryl L Smith; Dagmar Wirth; Carl H June; Kenneth B Margulies; Rajan Jain; Ellen Puré; Steven M Albelda; Jonathan A Epstein
Journal:  Nature       Date:  2019-09-11       Impact factor: 49.962

8.  Senolytic CAR T cells reverse senescence-associated pathologies.

Authors:  Corina Amor; Judith Feucht; Josef Leibold; Yu-Jui Ho; Changyu Zhu; Direna Alonso-Curbelo; Jorge Mansilla-Soto; Jacob A Boyer; Xiang Li; Theodoros Giavridis; Amanda Kulick; Shauna Houlihan; Ellinor Peerschke; Scott L Friedman; Vladimir Ponomarev; Alessandra Piersigilli; Michel Sadelain; Scott W Lowe
Journal:  Nature       Date:  2020-06-17       Impact factor: 49.962

9.  Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.

Authors:  Marcus Ruscetti; John P Morris; Riccardo Mezzadra; James Russell; Josef Leibold; Paul B Romesser; Janelle Simon; Amanda Kulick; Yu-Jui Ho; Myles Fennell; Jinyang Li; Robert J Norgard; John E Wilkinson; Direna Alonso-Curbelo; Ramya Sridharan; Daniel A Heller; Elisa de Stanchina; Ben Z Stanger; Charles J Sherr; Scott W Lowe
Journal:  Cell       Date:  2020-03-31       Impact factor: 41.582

Review 10.  Engineering CAR-T Cells for Next-Generation Cancer Therapy.

Authors:  Mihe Hong; Justin D Clubb; Yvonne Y Chen
Journal:  Cancer Cell       Date:  2020-07-30       Impact factor: 31.743
  10 in total
  1 in total

Review 1.  The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases.

Authors:  Carmine Izzo; Paolo Vitillo; Paola Di Pietro; Valeria Visco; Andrea Strianese; Nicola Virtuoso; Michele Ciccarelli; Gennaro Galasso; Albino Carrizzo; Carmine Vecchione
Journal:  Life (Basel)       Date:  2021-01-15
  1 in total

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