Literature DB >> 33467601

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases.

Carmine Izzo1, Paolo Vitillo1, Paola Di Pietro1, Valeria Visco1, Andrea Strianese1, Nicola Virtuoso1, Michele Ciccarelli1, Gennaro Galasso1, Albino Carrizzo1,2, Carmine Vecchione1,2.   

Abstract

Aging can be seen as process characterized by accumulation of oxidative stress induced damage. Oxidative stress derives from different endogenous and exogenous processes, all of which ultimately lead to progressive loss in tissue and organ structure and functions. The oxidative stress theory of aging expresses itself in age-related diseases. Aging is in fact a primary risk factor for many diseases and in particular for cardiovascular diseases and its derived morbidity and mortality. Here we highlight the role of oxidative stress in age-related cardiovascular aging and diseases. We take into consideration the molecular mechanisms, the structural and functional alterations, and the diseases accompanied to the cardiovascular aging process.

Entities:  

Keywords:  aging; cardiovascular diseases; molecular mechanisms; oxidative stress

Year:  2021        PMID： 33467601      PMCID： PMC7829951          DOI： 10.3390/life11010060

Source DB:  PubMed          Journal:  Life (Basel)        ISSN： 2075-1729


  479 in total

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