Nauman H Malik1,2, Manjula Maganti3,4, Maurene McQuestion1,2,5, Michael C Tjong1,2, Dana Keilty1,2, Eric Monteiro6, Shao Hui Huang1,2, Raymond Woo-Jun Jang7, Andrea Gomes8, Joanne Pun2,9, Jolie Ringash10,11,12. 1. Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. 2. Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Ave, Toronto, ON, M5G 2M9, Canada. 3. Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada. 4. University Health Network, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada. 5. Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada. 6. Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada. 7. Department of Medical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. 8. Department of Speech Language Pathology, University of Toronto, Toronto, ON, Canada. 9. Clinical Nutrition, Princess Margaret Cancer Centre, Toronto, ON, Canada. 10. Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Jolie.Ringash@rmp.uhn.on.ca. 11. Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Ave, Toronto, ON, M5G 2M9, Canada. Jolie.Ringash@rmp.uhn.on.ca. 12. Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, ON, Canada. Jolie.Ringash@rmp.uhn.on.ca.
Abstract
BACKGROUND: To investigate the relationship between attendance to a pre-treatment psychoeducational intervention (prehab) with treatment outcomes and toxicities in patients receiving radiotherapy for head and neck cancers (HNCs). METHODS: Patients were included from prehab inception in 2013 to 2017, comparing overall survival (OS), locoregional recurrence-free survival (LRFS), and locoregional recurrence (LRR) between prehab attendees (PA) and non-attendees (PNA). Multivariable analysis was performed for OS and LRFS. RESULTS: Among 864 PA and 1128 PNA, 2-year OS was 88% vs 80% (p < 0.001), and LRFS was 84% vs 75% (p < 0.001). On multivariable analysis (MVA), OS and LRFS were independently and unfavourably associated with PNA. The PA cohort had a lower frequency of a "rocky treatment course" compared with the PNA cohort (52/150, 35% vs 71/150, 47%; p = 0.034). CONCLUSIONS: Prehab at our institution is associated with improved long-term oncologic outcomes. Prospective data is needed to better understand this association.
BACKGROUND: To investigate the relationship between attendance to a pre-treatment psychoeducational intervention (prehab) with treatment outcomes and toxicities in patients receiving radiotherapy for head and neck cancers (HNCs). METHODS:Patients were included from prehab inception in 2013 to 2017, comparing overall survival (OS), locoregional recurrence-free survival (LRFS), and locoregional recurrence (LRR) between prehab attendees (PA) and non-attendees (PNA). Multivariable analysis was performed for OS and LRFS. RESULTS: Among 864 PA and 1128 PNA, 2-year OS was 88% vs 80% (p < 0.001), and LRFS was 84% vs 75% (p < 0.001). On multivariable analysis (MVA), OS and LRFS were independently and unfavourably associated with PNA. The PA cohort had a lower frequency of a "rocky treatment course" compared with the PNA cohort (52/150, 35% vs 71/150, 47%; p = 0.034). CONCLUSIONS: Prehab at our institution is associated with improved long-term oncologic outcomes. Prospective data is needed to better understand this association.
Entities:
Keywords:
Head and neck cancers; Quality of life; Radiotherapy; Supportive care; Survivorship
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