Abhijeet Ashok Salunke1, Kunal Nandy2, Subodh Kumar Pathak3, Jaymin Shah4, Mayur Kamani2, Viswanth Kottakota2, Praveen Thivari3, Apurva Pandey5, Keval Patel2, Priyank Rathod2, Supreet Bhatt2, Pariseema Dave2, Shashank Pandya2. 1. Department of Surgical Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India. Electronic address: drabhijeetsalunke@gmail.com. 2. Department of Surgical Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India. 3. Department of Orthopedics, MMIMSR, M M Deemed to be University, Mullana, Ambala, India. 4. Department of Orthopedic Oncology, Osteocare Ortho Onco Clinic, Ahmedabad, Gujarat, India. 5. Department of Radiation Oncology, MMIMSR, MM Deemed to be University, Ambala, Haryana, India.
Abstract
BACKGROUND AND AIMS BACKGROUND: Currently there is limited knowledge on cancer and COVID-19; we conducted a systematic review and meta-analysis to evaluate the impact of cancer on serious events including ICU admission rate and mortality in COVID 19. METHODS: PubMed, Cochrane Central Register of Clinical Trials were searched on April 16, 2020, to extract published articles that reported the outcomes of cancer in COVID-19 patients. The search terms were "coronavirus" and "clinical characteristics" with no language or time restrictions. We identified 512 published results and 13 studies were included in the analysis. RESULTS: There were 3775 patients, of whom 63 (1·66%) had a cancer. The pooled estimates of ICU admission in COVID 19 patients with and without cancer were 40% versus 8·42%.The odds ratio of ICU admission rates between the cancer and non-cancer groups was 2.88 with a 95% CI of 1·18 to 7·01 (p = 0·026). The pooled estimates of death rate in COVID -19 patients with and without cancer were 20·83% versus 7·82%. The odds ratio of death rates between the cancer and non-cancer groups was 2.25 with a 95% CI ranging from 0·71 to 7·10 with p value of 0·166. The pooled prevalence of cancer patients was 2% (95 CI 1-4). CONCLUSIONS: Presence of cancer in COVID-19 leads to higher risk of developing serious events i.e. ICU admission, mechanical ventilation and mortality. The presence of cancer has a significant impact on mortality rate in COVID-19 patients.
BACKGROUND AND AIMS BACKGROUND: Currently there is limited knowledge on cancer and COVID-19; we conducted a systematic review and meta-analysis to evaluate the impact of cancer on serious events including ICU admission rate and mortality in COVID 19. METHODS: PubMed, Cochrane Central Register of Clinical Trials were searched on April 16, 2020, to extract published articles that reported the outcomes of cancer in COVID-19patients. The search terms were "coronavirus" and "clinical characteristics" with no language or time restrictions. We identified 512 published results and 13 studies were included in the analysis. RESULTS: There were 3775 patients, of whom 63 (1·66%) had a cancer. The pooled estimates of ICU admission in COVID 19patients with and without cancer were 40% versus 8·42%.The odds ratio of ICU admission rates between the cancer and non-cancer groups was 2.88 with a 95% CI of 1·18 to 7·01 (p = 0·026). The pooled estimates of death rate in COVID -19patients with and without cancer were 20·83% versus 7·82%. The odds ratio of death rates between the cancer and non-cancer groups was 2.25 with a 95% CI ranging from 0·71 to 7·10 with p value of 0·166. The pooled prevalence of cancerpatients was 2% (95 CI 1-4). CONCLUSIONS: Presence of cancer in COVID-19 leads to higher risk of developing serious events i.e. ICU admission, mechanical ventilation and mortality. The presence of cancer has a significant impact on mortality rate in COVID-19patients.
Authors: Hua Zhang; Han Han; Tianhui He; Kristen E Labbe; Adrian V Hernandez; Haiquan Chen; Vamsidhar Velcheti; Justin Stebbing; Kwok-Kin Wong Journal: J Natl Cancer Inst Date: 2021-03-01 Impact factor: 13.506
Authors: H Rahimi; A Allahyari; S Ataei Azimi; M Kamandi; Z Mozaheb; F Zemorshidi; M Khadem-Rezaiyan; A Bary; M Seddigh-Shamsi; M Moeini Nodeh Journal: Trials Date: 2021-05-19 Impact factor: 2.279
Authors: Omar Al Zahrani; Ismail Ghorbel; Osama Mukhtar; Muneera Almajed; Hoda M Abdelazim; Muhammad N Hasan; Ahmad Mostafa; Aisha A Al Harbi; Ali Bajouda Journal: Saudi Med J Date: 2021-12 Impact factor: 1.422