Semra Kulekci Ozturk1, Elif Sakci2, Cem Kavvasoglu3. 1. Department of Otorhinolaryngology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey. skulekcikbb@gmail.com. 2. Department of Internal Medicine, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey. 3. Department of Otorhinolaryngology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
Abstract
OBJECTIVES: Our aim was to evaluate the rhinological changes during hypothyroid and euthyroid periods in patients with acquired hypothyroidism. MATERIALS AND METHODS: The newly diagnosed 40 adult patients with hypothyroidism who presented to the Endocrinology clinic at a tertiary hospital were enrolled in the study. Patients having blood thyroid-stimulating hormone levels greater than 4.95 IU/dl were consulted to the ENT clinic. Nasal Obstruction Symptom Evaluation scores, Peak Nasal Inspiratory Flow rates and nasal mucociliary clearance time of patients were noted before and 4 months after the oral levothyroxine sodium tablet treatment. RESULTS: Of the patients included in the study, 34 (85%) were females and 6 (15%) were males. The mean thyroid-stimulating hormone values before the treatment was 10.01 ± 3.31 IU/dl and 4.03 ± 2.45 IU/dl at the end of the treatment. The difference in values was statistically significant (p < 0.001). The mean mucociliary clearance time before treatment was 8.03 ± 3.29 min and 7.35 ± 2.87 min at the end of treatment. The decrease in mucociliary clearance time was statistically significant (p = 0.001). We did not detect any significant difference between pre- and posttreatment values of nasal obstruction symptom evaluation scores and peak nasal inspiratory flow rates. CONCLUSION: The patients with hypothyroidism have prolonged mucociliary clearance time in hypothyroid period of the disease. Regarding to this data, we may recommend clinicians to follow-up these patients more closely for respiratory tract diseases and sinonasal infections.
OBJECTIVES: Our aim was to evaluate the rhinological changes during hypothyroid and euthyroid periods in patients with acquired hypothyroidism. MATERIALS AND METHODS: The newly diagnosed 40 adult patients with hypothyroidism who presented to the Endocrinology clinic at a tertiary hospital were enrolled in the study. Patients having blood thyroid-stimulating hormone levels greater than 4.95 IU/dl were consulted to the ENT clinic. Nasal Obstruction Symptom Evaluation scores, Peak Nasal Inspiratory Flow rates and nasal mucociliary clearance time of patients were noted before and 4 months after the oral levothyroxine sodium tablet treatment. RESULTS: Of the patients included in the study, 34 (85%) were females and 6 (15%) were males. The mean thyroid-stimulating hormone values before the treatment was 10.01 ± 3.31 IU/dl and 4.03 ± 2.45 IU/dl at the end of the treatment. The difference in values was statistically significant (p < 0.001). The mean mucociliary clearance time before treatment was 8.03 ± 3.29 min and 7.35 ± 2.87 min at the end of treatment. The decrease in mucociliary clearance time was statistically significant (p = 0.001). We did not detect any significant difference between pre- and posttreatment values of nasal obstruction symptom evaluation scores and peak nasal inspiratory flow rates. CONCLUSION: The patients with hypothyroidism have prolonged mucociliary clearance time in hypothyroid period of the disease. Regarding to this data, we may recommend clinicians to follow-up these patients more closely for respiratory tract diseases and sinonasal infections.
Authors: Natalia Weare-Regales; Sergio E Chiarella; Juan Carlos Cardet; Y S Prakash; Richard F Lockey Journal: J Allergy Clin Immunol Pract Date: 2022-04-15
Authors: Hyo Geun Choi; Tae Jun Kim; Sung Kwang Hong; Chanyang Min; Dae Myoung Yoo; Heejin Kim; Joong Seob Lee Journal: Int J Environ Res Public Health Date: 2022-07-08 Impact factor: 4.614