Determinants of Medication Adherence for Pulmonary Tuberculosis Patients During Continuation Phase in Dalian, Northeast China.

PURPOSE: Medication adherence is crucial for decreasing the burden of tuberculosis, but few relevant studies have been conducted in northeast China. This study aimed to explore the level of medication adherence among pulmonary tuberculosis outpatients and the predictive factors based on the bio-psycho-social medical model. PATIENTS AND METHODS: A cross-sectional multi-center survey was conducted in four tuberculosis medical institutions in Dalian, northeast China. Medication adherence was measured using the eight-item Chinese version of the Morisky Medication Adherence Scale, which divides adherence into three levels. The independent variables consisted of sociodemographic characteristics, treatment factors, knowledge about TB, mental health, and behavioral characteristics. Descriptive statistics, the chi-square test, and multivariate ordinal logistic regression were applied to analyze the data using Stata/MP 14.0.
RESULTS: Among the 564 eligible participants, 236 (41.84%) and 183 (32.45%) exhibited high and medium medication adherence, respectively, but 145 (25.71%) exhibited low medication adherence. Multivariate ordinal logistic regression showed that patients who were older (OR: 1.02, p=0.013) were employed (OR: 1.61, p=0.011), had better tuberculosis knowledge (OR: 1.34, p<0.001), and did not consume alcohol (OR: 1.84, p=0.032) exhibited higher medication adherence. However, patients who did not follow their doctors' advice to take adjuvant drugs (OR: 0.44, p=0.001), had a history of TB treatment (OR: 1.76, p=0.009), experienced adverse drug reactions (OR: 0.65, p=0.017), experienced stigma (OR: 0.67, p=0.032), and needed supervised treatment (OR: 0.66, p=0.012) exhibited lower medication adherence.
CONCLUSION: Tuberculosis patients' medication adherence was not very high and it was influenced by diverse and complex factors involving sociodemographic characteristics, treatment factors, knowledge about TB, mental health, and behavioral characteristics.

Introduction

Tuberculosis (TB) is a widespread infectious disease caused by Mycobacterium tuberculosis (MTB). According to the World Health Organization (WHO), there were about 10.0 million new TB cases (range, 9.0–11.1 million), equivalent to 133 cases (range, 120–148) per 100 000, worldwide in 2018.1 TB is also one of the top 10 causes of death globally and it caused an estimated 1.2 million (range, 1.1–1.3 million) deaths in 2018.1 Although free anti-TB medicines (including isoniazid, rifampicin, ethambutol, streptomycin, pyrazinamide and so on) have been provided free of charge by the government, China has now the second-highest TB burden in the world, accounting for about 9% of cases, following India (27%).1 It showed high morbidity and mortality of TB in northeast China according to the China Health Statistics Yearbook in 2019. The global End TB strategy is difficult to carry out in the current Chinese context, but medication adherence is a crucial issue related to TB prevention and control.2,4

The TB patients have to require typically at least 6 months of treatment regimen. After an intensive phase treatment for 2 months with a four-drug regimen (isoniazid, rifampicin, pyrazinamide, ethambutol), the TB patients have to accept the continuation phase lasting more than 4 months according to the WHO recommendation. TB patients could be more likely to show non-adherence in continuation phase because they have improved signs and symptoms of the disease and even might think they are cured; thus, they might be careless in taking medications.5,6 Poor anti-TB medication adherence not only causes disease deterioration, relapse, and even drug resistance but also the spread of MTB to others, which increases the burden related to TB control.4,7 However, previous studies demonstrated that the medication adherence of Chinese TB patients under the directly observed treatment short-course (DOTS) strategy recommended by the WHO was not very perfect, especially in economically disadvantaged areas and among migrant patients. A survey in five provinces of central and western China found that about 20% of TB patients did not adhere to regular treatment.8 Over a third of TB patients exhibited low medication adherence according to another study conducted in west China.9 A study conducted in 12 counties in Shandong province in east China indicated that migrant TB patients exhibited inferior medication adherence.10 TB patients’ medication adherence is clearly not very high in a certain population of China, and there is a lack of research on this topic in northeast China.

Many quantitative studies have explored the factors associated with medication adherence among TB patients in the past decades. A cross-sectional questionnaire-based study conducted in Russia found that social and psychological factors were significantly associated with medication adherence among TB patients.11 Another study conducted in Sri Lanka found that treatment-related adverse events, such as experiencing side effects of anti-TB drugs, were associated with low medication adherence.12 Additionally, knowledge about TB treatment and mental health (such as anxiety and stigma) have been shown to be important determinants of medication adherence.13,15 Moreover, a previous study has found that unhealthy habits such as smoking and alcohol consumption are also associated with low medication adherence.16 However, previous studies in China only explored the determinants of TB patients’ medication adherence by assessing sociodemographic factors,9 TB knowledge and cognition,17 medication supervision mode and social support,10 with a lack of research on treatment factors and stigma.

TB patients’ medication adherence should not only be considered as a clinical issue but also a public health problem. The bio-psycho-social medical model emphasizes that psychological and social factors that influence human health promotion should be considered in addition to biological factors, in contrast to the traditional medical model that emphasizes biological determinants.18,19 Based on this model, the purpose of this study was to explore the level of TB patients’ medication adherence in northeast China during the continuation phase, in which patients tend to be more likely to exhibit poor adherence,20 and to analyze the determinants of medication adherence in terms of sociodemographic characteristics, treatment factors, knowledge about TB, mental health, and behavioral characteristics.

Patients and Methods

Study Design and Setting

This cross-sectional multi-center survey was conducted between June 20, 2019 and August 31, 2019. Four medical institutions in Dalian, Liaoning province, in northeast China were involved. The four medical institutions, which served different types of TB patients, were chosen according to their institution level and location. The first medical institution was the Dalian TB hospital, which mainly serves TB patients across the whole city, especially critically ill and urban patients. The second was Pulandian TB hospital, which is a branch hospital of the first hospital and it serves both rural and urban TB patients. The other two medical institutions were Zhuanghe and Lvshun TB dispensaries, which only serve local patients with milder TB. Outpatients with pulmonary TB who had been taking anti-TB medicine for >2 months were eligible. We excluded patients aged <15 years and patients who were unable to complete the questionnaire due to unconsciousness. Beside the members of our research team, we recruited 15 interviewers from the School of Public Health at Dalian Medical University. We trained the interviewers before conducting the formal face-to-face interview, and they were responsible for filling in the questionnaire.

Questionnaire

The questionnaire was designed based on a literature review and expert consultation. It mainly collected data on medication adherence, sociodemographic characteristics, treatment factors, knowledge about TB, mental health, and behavioral characteristics. Medication adherence was assessed using the eight-item Morisky Medication Adherence Scale (MMAS-8),21 which is a process-oriented way to measure medication adherence.22 The scale has acceptable reliability and validity, and Cronbach’s α was 0.74 in the current study. Each item represents a score of 1, and the maximum score is 8. Medication adherence was divided into three levels according to previous studies (8: high adherence; 6 to <8: medium adherence; and <6: low adherence).23,24

Based on the bio-psycho-social medical model, factors that potentially influenced medication adherence were divided into four aspects. First, we took sociodemographic characteristics into consideration, comprising patients’ gender, age, employment status, migration status, residence (urban or rural), and education level. Second, we assessed treatment factor, comprising a previous history of TB treatment, medication duration (from the beginning of treatment to the survey date), number of anti-TB medicines, taking only free anti-TB medicine, adjuvant drug usage (such as hepatinica) and adverse drug reactions. Third, we considered participants’ knowledge about TB and mental health (anxiety and stigma). We used six commonsense questions on Chinese TB prevention and control practices to assess TB knowledge, such as “What do you think the main route of TB transmission is?” and “What do you think irregular anti-TB medication usage will bring about?” Each question had four options and each correct answer was worth one point. We also recorded self-assessed TB severity. Anxiety was measured using the 7-item Generalized Anxiety Disorder scale (GAD-7)25 and divided into four levels (minimal, mild, moderate, and severe);25 Cronbach’s α was 0.95 in the current study. Perceived stigma was measured using a 9-item stigma questionnaire developed according to the Chinese sociocultural context26 and divided into a binary variable (Yes/No) based on the median score;26 Cronbach’s α was 0.89 in the current study. Fourth, we assessed behavioral characteristics, comprising smoking, alcohol consumption, and treatment supervision (need or no need for supervision from family, doctors, or others when taking anti-TB medicine).

Statistical Analysis

A sample of 593 records containing the questionnaire data was collected, and we authors used EpiData software version 3.1 (EpiData Association, Odense, Denmark) to set up a database to enter the questionnaire data. We deleted records if they contained >20% missing values, leading to 564 eligible records in the final sample. The categorical variables are described using numbers and percentages, and the continuous variables are described using mean and median. Intergroup comparisons were performed using the chi-square test for categorical variables. Ordinal multivariate logistic regression was performed to determine the predictors of TB patients’ medication adherence; odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. To test as many variables as possible, we introduced variables with p-value <0.25 in the chi-square tests into the multivariate regression model. The level of statistical significance was p-value <0.05. All statistical analyses were performed using Stata/MP version 14.0 (StataCorp, College Station, TX, USA).

Ethics Approval and Informed Consent

The study protocol was reviewed and approved by the ethics committee of Dalian Medical University, Liaoning province, China. The ethics committee of Dalian Medical University also approved participants under the age of 18 years providing written informed consent on their own behalf. Prior to being interviewed by staff from the School of Public Health at Dalian Medical University (who filled in the questionnaires), participants received verbal and written information about the purpose and structure of the interview, and they signed an informed consent form to participate in our study. For the participants under the age of 18 years, we ask for the permission from them and their parents before the patients wrote the informed consent.

Results

Sociodemographic Characteristics

Among the 564 participants, 236 (41.84%) and 183 (32.45%) exhibited high and medium medication adherence, respectively, but 145 (25.71%) exhibited low medication adherence. There were about twice as many male patients (66.31%) as female patients (33.69%). The mean age was 47.41 years and the median was 49 years (interquartile range 31 years). Most patients were employed (71.63%) even though they were still in the TB treatment phase, but 160 (28.37%) were unemployed. Only 93 (16.49%) were migrants, and there were slightly more rural patients (52.66%) than urban patients (47.34%). Middle school education (34.22%) was the most common education level, and the percentages among the other education levels were almost the same as each other. The chi-square tests indicated that unemployment and education were associated with medication adherence (p<0.05) (Table 1).

Table 1

Medication Adherence Level by Demographic and Social Characteristics

Variable	Description	N (%)	Adherence Level			Chi-Square Test p-value
			Low	Medium	High
Gender	Male	374 (66.31)	91	119	164	0.364
	Female	190 (33.69)	54	64	72
Age (years)	<21	26 (4.61)	11	11	4	0.093
	21–40	196 (34.75)	51	61	84
	41–60	181 (32.09)	38	63	80
	>60	161 (28.55)	45	48	68
Unemployment	Yes	160 (28.37)	49	61	50	0.006
	No	404 (71.63)	96	122	186
Immigration	Yes	93 (16.49)	27	31	35	0.614
	No	471 (83.51)	118	152	201
Residence	Urban	267 (47.34)	71	79	117	0.386
	Rural	297 (52.66)	74	104	119
Education	Primary or below	123 (21.28)	40	39	44	0.031
	Middle school	193 (34.22)	42	69	82
	High school	120 (21.28)	33	26	61
	College or above	128 (22.70)	30	49	49

Treatment Factors

Over 80% of participants were new TB patients, and only 107 (18.97%) had a history of TB treatment. The mean medication duration was 7.87 months and the median was 6 months; 332 (58.87%) patients had a medication duration of 2–6 months, and 91 (16.13%) had a medication duration of >12 months. The median number of anti-TB medicines was three, and 48.94% of the patients took >3 medicines. About one-fifth only took free anti-TB medicine and did not purchase extra anti-TB drugs. Most of the patients (87.59%) took adjuvant medicine (such as hepatinica) according to their doctors’ advice. There were 199 (35.28%) patients who reported having adverse drug effects such as nausea, stomach discomfort, and liver pain. The chi-square tests indicated that having a history of TB treatment, taking adjuvant drugs and experiencing adverse effects were associated with medication adherence (p<0.05) (Table 2).

Table 2

Medication Adherence Level by TB Patients’ Treatment Factors

Variable	Description	N (%)	Adherence Level			Chi-Square Test p-value
			Low	Medium	High
History of TB treatment	Yes	107(18.97)	44	30	33	<0.001
	No	457(81.03)	101	153	203
Medication duration (months)	2–6	332 (58.87)	80	110	142	0.095
	7–9	84 (14.89)	17	28	39
	10–12	57 (10.11)	20	11	26
	>12	91 (16.13)	28	34	29
Number of anti-TB medicines	≤3	288 (51.06)	78	80	130	0.052
	>3	276 (48.94)	67	103	106
Free anti-TB medicine only	Yes	113 (20.04)	30	40	43	0.637
	No	451 (79.96)	115	143	193
Adjuvant drug use	Yes	494 (87.59)	121	153	220	0.003
	No	70 (12.41)	24	30	16
Adverse drug reaction	Yes	199 (35.28)	63	70	66	0.005
	No	365 (64.72)	82	113	170

Abbreviation: TB, tuberculosis.

TB Knowledge and Mental Health Status

The mean TB knowledge score was 4.58 and the median was 5. Many patients (61.35%) had a good knowledge of TB prevention and treatment (score, 5–6), but 44 (7.80%) had a score <3. Among the participants, 386 (68.44%) had no or mild anxiety, but approximately 6% reported moderate or severe anxiety during TB treatment. The mean stigma score was 18.45 and the median was 19; 247 (43.79%) patients reported self-perceived stigma. Many participants reported that their disease was not very serious (41.31%); 140 (24.82%) thought their disease not serious at all; but about one-third thought their disease was moderate to very serious. The chi-square tests indicated that anxiety, stigma, and knowledge about TB were all significantly associated with medication adherence (p<0.05) (Table 3).

Table 3

Medication Adherence Level by TB Patients’ Knowledge About TB and Mental Health

Variable	Description	N (%)	Adherence Level			Chi-Square Test p-value
			Low	Medium	High
Knowledge about TB	1–2	44 (7.80)	21	14	9	0.001
	3–4	174 (30.85)	51	58	65
	5–6	346 (61.35)	73	111	162
Anxiety	Minimal	386 (68.44)	94	108	184	<0.001
	Mild	141 (25.00)	36	65	40
	Moderate	26 (4.61)	9	8	9
	Severe	11 (1.95)	6	2	3
Stigma	No	317 (56.21)	62	103	152	<0.001
	Yes	247 (43.79)	83	80	84
Self-assessed severity	Very serious	12 (2.13)	4	4	4	0.065
	Serious	60 (10.64)	21	22	17
	Moderately serious	119 (21.10)	39	39	41
	Not very serious	233 (41.31)	47	77	109
	Not serious at all	140 (24.82)	34	41	65

Abbreviation: TB, tuberculosis.

Behavioral Characteristics

Most participants did not smoke while in the treatment period, but there were still 88 (15.60%) patients who could not quit smoking. Patients who did not consume alcohol (89.89%) accounted for the vast majority, but 57 (10.11%) reported that they consumed alcohol while in treatment. Over half of the patients reported unsupervised treatment, taking their anti-TB medicine on their own. However, 239 (42.38%) could not do this and needed family, doctors, or others to remind them to take their anti-TB medicine. The chi-square test indicated that alcohol consumption was associated with medication adherence (p<0.05) (Table 4).

Table 4

Medication Adherence Level by TB Patients’ Behavioral Characteristics

Variable	Description	N (%)	Adherence Level			Chi-Square Test p-value
			Low	Medium	High
Smoking	Yes	88 (15.60)	29	30	29	0.123
	No	476 (84.40)	116	153	207
Alcohol consumption	Yes	57 (10.11)	20	22	15	0.038
	No	507 (89.89)	125	161	221
Medication supervision	Unsupervised	325 (57.62)	75	107	143	0.226
	Supervised	239 (42.38)	70	76	93

Abbreviation: TB, tuberculosis.

Determinants of Patients’ Medication Adherence Based on Ordinal Logistic Regression

The ordinal logistic regression results showed that increasing age led to an increase in medication adherence (p=0.013). In addition, medication adherence increased with employment (OR: 1.61, 95% CI: 1.12–2.32, p=0.011), knowledge about TB prevention and treatment (OR: 1.34, 95% CI: 1.16–1.54, p<0.001), and lack of alcohol consumption (OR: 1.84, 95% CI: 1.05–3.22, p=0.032) during the treatment period. In contrast, those who did not follow their doctors’ advice regarding taking adjuvant drugs (OR: 0.44, 95% CI: 0.27–0.72, p=0.001), had history of TB treatment (OR: 1.76, 95% CI: 1.15–2.69, p=0.009), experienced anti-TB drug adverse effects (OR: 0.65, 95% CI: 0.46–0.93, p=0.017), experienced stigma (OR: 0.67, 95% CI: 0.47–0.97, p=0.032), or had supervised treatment (OR: 0.66, 95% CI: 0.47–0.91, p=0.012) tended to perform lower medication adherence (Table 5).

Table 5

Ordinal Logistic Regression Exploring Medication Adherence Among TB Patients

Variable	Reference Category	Coefficient	p-value	OR	95% CI for OR
					Low	High
Age	-	0.01	0.013	1.02	1.00	1.03
Unemployment	Yes	0.48	0.011	1.61	1.12	2.32
Education	-	0.10	0.305	1.11	0.91	1.34
History of TB treatment	Yes	0.56	0.009	1.76	1.15	2.69
Medication duration	-	−0.12	0.090	0.89	0.77	1.02
Number of medicines	-	0.05	0.379	1.05	0.94	1.18
Adjuvant drug use	Yes	−0.82	0.001	0.44	0.27	0.72
Adverse drug reaction	No	−0.42	0.017	0.65	0.46	0.93
Knowledge about TB	-	0.29	<0.001	1.34	1.16	1.54
Anxiety	-	−0.04	0.069	0.96	0.92	1.00
Stigma	No	−0.39	0.032	0.67	0.47	0.97
Self-assessed severity	-	0.07	0.426	1.07	0.90	1.27
Smoking	Yes	0.30	0.204	1.35	0.85	2.16
Alcohol consumption	Yes	0.61	0.032	1.84	1.05	3.22
Medication supervision	Unsupervised	−0.42	0.012	0.66	0.47	0.91

Note: “-” means not applicable.

Abbreviations: TB, tuberculosis; OR, odds ratio; CI, confidence interval.

Discussion

This study aimed to assess pulmonary TB patients’ medication adherence and explore its determinants by assessing sociodemographic characteristics, treatment factors, knowledge about TB, mental health, and behavioral characteristics. The strengths of our study included the fact that it was conducted in northeast China, where few relevant studies have been conducted. Additionally, based on the bio-psycho-social medical model, we innovatively introduced treatment factors and perceived stigma into the analysis of medication adherence determinants in the Chinese context. The results showed that, overall, TB patients’ medication adherence was not very high, and only 41.84% reported high adherence to their anti-TB medicine regimen. In addition, various factors were associated with medication adherence and it is imperative to explore the reasons and formulate feasible measures to improve medication adherence.

We found that medication adherence increased with age, which may be because the older patients exhibited more socially conscious behavior, and had more life experiences and stronger ideology that led them to adhere more strongly to their anti-TB medicine regimen. In a study in the USA, older latently infected TB patients exhibited a higher treatment completion rate than the younger patients.27 In contrast, younger TB patients may be more likely to be non-adherent because of various risk factors,28 so we should pay more attention to young patients and adopt enhanced adherence measures if necessary.29 In addition, we found that unemployed patients exhibited insufficient medication adherence. As a chronic disease, TB patients require extra money over the long term to purchase adjuvant drugs and health services in addition to the free treatment provided in China, and TB can cause a heavy financial burden on a patient’s family if he or she is unemployed.30,32 Being employed not only contributes to resolving the problem of the financial burden of TB treatment, but it increases social participation, which may be beneficial to increase medication adherence. However, many Chinese employers discriminate against patients with infections, especially pulmonary TB, and are unwilling to hire them. Therefore, the government should take patients’ employment status into consideration when they formulate supportive policies to promote anti-TB medication adherence.

Several treatment factors, but not all, were significantly associated with medication adherence. Our study found that the relapse TB patients were more likely to show low medication adherence than the new diagnosed ones. The new TB patients may have stronger confidence and determination to cure the disease which facilitate them to take anti-tuberculosis medicine in time and quantity; however, the relapse patients may hold the idea that the disease would recur even it is cured temporarily and they may also require more complicated treatment, so they could take medicine not seriously.33,34 In a previous study, medication duration was significantly negatively associated with medication adherence,35 but the association in our study was not significant (p=0.090), which may be due to regional differences. Additionally, the number of anti-TB drugs patients took and whether they only took free anti-TB drugs were not associated with medication adherence. Thus, these aspects of the medication regimen itself did not decrease adherence, but rather the other effects of the medication (adjuvant medicine use and adverse drug effects) did. In practice, doctors prescribe anti-TB drugs together with adjuvant medicine (such as hepatinica) to protect the patients’ organs from damage, but a few patients in our study did not follow their doctors’ advice to take adjuvant medicine. Refusal of adjuvant medicine was associated with lower medication adherence, which may be because: 1) some patients may express disgust at both anti-TB medicine and the adjuvant drugs when taking various medicines every day,36 2) not taking adjuvant medicine would lead to more adverse drug reactions. Moreover, adverse drug reactions were associated with low medication adherence. If patients are not informed in advance about the adverse effects caused by anti-TB drugs by medical staff, patients can become fearful in response to adverse effects and even abandon treatment.37,38 Therefore, it is urgent to enhance patient–doctor communication regarding the effects of the adjuvant and anti-TB medicines’ adverse effects to eliminate patients’ misunderstandings about the treatment process.

Medication adherence significantly increased when participants had a good understanding of TB prevention and treatment. A case–control study conducted in Kenya also found that inadequate knowledge about TB was independently associated with low medication adherence.13 The current public education about TB prevention and treatment in China is insufficient.39 Most pulmonary TB patients can be cured if they take medicine regularly40 but, according to the present survey, some participants were unsure of whether the disease could be cured and some did not know the treatment duration. Therefore, comprehensive education and counseling at TB treatment initiation is important to improve medication adherence.38,41,42 Additionally, patients who perceived stigma exhibited significantly reduced medication adherence, which is consistent with a previous qualitative study conducted in South Africa.15 However, according to a case–control study in Korea, the absence of stigma was unexpectedly a predictor of low adherence.43 Stigma should not be thought of as a problem of patients themselves, but as a serious social issue in the current Chinese sociocultural context.26 Patients who experience stigma may be solitary, lacking assistance, and dispirited, which could affect their confidence in anti-TB treatment. Hence, it is necessary to reduce the social prejudice against TB patients and pay more attention to supplying psychological support to increase medication adherence.

Unhealthy habits were another important aspect of predicting medication adherence. Alcohol consumption was associated with low medication adherence. Alcohol consumption can paralyze nerves and cause unconsciousness, which could result in forgetting to take anti-TB medicine.44,45 Moreover, both alcohol consumption and taking anti-TB medicine can cause liver damage, which could reduce the patients’ motivation to take the medication due to experiencing body pain.46 In addition, we found that unsupervised treatment was associated with increased medication adherence. This may be interpreted as reflecting the fact that patients who managed their own treatment may be proactive and have increased acceptance of regularly taking anti-TB treatment, which manifested in increased medication adherence. In contrast, patients who need treatment supervision may be careless about their disease and reluctant to take their medicine. Of course, further specifically designed studies are needed to clarify the reasons for this result. Based on these findings, medical personnel should increase awareness about the harm of alcohol consumption during treatment, and valid measures should be implemented to enhance supervised treatment and patients’ motivation to take treatment.

Several limitations in this study should be mentioned. The cross-sectional design could only indicate the current medication adherence of TB patients, so the associations observed in the study cannot be interpreted as causal associations between various statistically significant factors and medication adherence. Additionally, limitation regarding the sources of the sample may restrict the generalization of the study conclusions, as they may not be representative of other areas. Moreover, there could be reporting bias because the participants were required to self-report the relevant information. Finally, there was a lack of deep analysis of the mediation effects regarding medication adherence, so complex mechanisms influencing medication adherence were not explored in detail. Given these limitations, conducting future research on longitudinal and systematic (including medical) data is essential to effectively explore more determinants of medication adherence.

Conclusion

This study on the medication adherence of pulmonary TB patients was conducted in Dalian in northeast China, where there has previously been a lack of relevant research. Further, we explored the determinants of medication adherence based on the bio-psycho-social medical model. Tuberculosis patients’ medication adherence was not very high. The factors influencing the medication adherence of TB patients are diverse and complex which involved sociodemographic characteristics, treatment factors, knowledge about TB, mental health, and behavioral characteristics. Patients who were older were employed, had more knowledge about TB, and did not consume alcohol were more likely to have increased medication adherence. However, those who did not follow their doctors’ advice to take adjuvant drugs, experienced anti-TB drug adverse effects, had a history of TB treatment, experienced perceived stigma, and had supervised treatment tended to exhibit lower medication adherence during treatment. Therefore, in particular, social support, sufficient health education and counseling, indispensable alcohol control and medication supervision interventions are recommended to effectively improve medication adherence.