Literature DB >> 32752923

The immunomodulatory role of Regnase family RNA-binding proteins.

Maximilian Fischer1,2, Tobias Weinberger1,2, Christian Schulz1,2.   

Abstract

RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune homoeostasis. Four members, Regnase1-4, have been identified to date. Here we summarize recent findings on the role of Regnase in the regulation of RNA biology and its consequences for cell functions and inflammatory processes.

Entities:  

Keywords:  RNA-binding protein; Regnase; immune cells; immune homoeostasis; inflammation

Year:  2020        PMID： 32752923      PMCID： PMC7714472          DOI： 10.1080/15476286.2020.1795584

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  47 in total

1.  Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9.

Authors:  Andreas Pichlmair; Sandra S Diebold; Stephen Gschmeissner; Yasuhiro Takeuchi; Yasuhiro Ikeda; Mary K Collins; Caetano Reis e Sousa
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

2.  Deregulation of a possible tumour suppressor gene, ZC3H12D, by translocation of IGK@ in transformed follicular lymphoma with t(2;6)(p12;q25).

Authors:  Kentaro Minagawa; Katsuya Yamamoto; Shinichiro Nishikawa; Mitsuhiro Ito; Akiko Sada; Kimikazu Yakushijin; Atsuo Okamura; Manabu Shimoyama; Yoshio Katayama; Toshimitsu Matsui
Journal:  Br J Haematol       Date:  2007-10       Impact factor: 6.998

Review 3.  A census of human RNA-binding proteins.

Authors:  Stefanie Gerstberger; Markus Hafner; Thomas Tuschl
Journal:  Nat Rev Genet       Date:  2014-11-04       Impact factor: 53.242

4.  Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.

Authors:  Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
Journal:  Nature       Date:  2019-12-18       Impact factor: 49.962

5.  MCP-induced protein 1 attenuates sepsis-induced acute lung injury by modulating macrophage polarization via the JNK/c-Myc pathway.

Authors:  Yang Zhang; Tianfeng Huang; Lulu Jiang; Ju Gao; Dapeng Yu; Yali Ge; Shunyan Lin
Journal:  Int Immunopharmacol       Date:  2019-07-16       Impact factor: 4.932

6.  Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.

Authors:  Kazufumi Matsushita; Osamu Takeuchi; Daron M Standley; Yutaro Kumagai; Tatsukata Kawagoe; Tohru Miyake; Takashi Satoh; Hiroki Kato; Tohru Tsujimura; Haruki Nakamura; Shizuo Akira
Journal:  Nature       Date:  2009-03-25       Impact factor: 49.962

7.  Zc3h12c inhibits vascular inflammation by repressing NF-κB activation and pro-inflammatory gene expression in endothelial cells.

Authors:  Ling Liu; Zhou Zhou; Shengping Huang; Yanhong Guo; Yanbo Fan; Ji Zhang; Jifeng Zhang; Mingui Fu; Y Eugene Chen
Journal:  Biochem J       Date:  2013-04-01       Impact factor: 3.857

8.  DNA Methylation Profiling Reveals the Change of Inflammation-Associated ZC3H12D in Leukoaraiosis.

Authors:  Wen-Qing Huang; Ke-Hui Yi; Zhi Li; Han Wang; Ming-Li Li; Liang-Liang Cai; Hui-Nuan Lin; Qing Lin; Chi-Meng Tzeng
Journal:  Front Aging Neurosci       Date:  2018-05-23       Impact factor: 5.750

9.  Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.

Authors:  Hiroki Tanaka; Yasunobu Arima; Daisuke Kamimura; Yuki Tanaka; Noriyuki Takahashi; Takuya Uehata; Kazuhiko Maeda; Takashi Satoh; Masaaki Murakami; Shizuo Akira
Journal:  J Exp Med       Date:  2019-05-09       Impact factor: 14.307

10.  MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation.

Authors:  Ren-Jye Lin; Hsu-Ling Chien; Shyr-Yi Lin; Bi-Lan Chang; Han-Pang Yu; Wei-Chun Tang; Yi-Ling Lin
Journal:  Nucleic Acids Res       Date:  2013-01-25       Impact factor: 16.971
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