| Literature DB >> 32749573 |
Mateus V Thomazella1, Quirino A Lima Neto2, Francisco F Duarte Junior2, Fernando A Jorge2, Déborah de Castro Moreira2, Amauri D Leal Junior2, Mayra M Presibella3, Irina N Riediger3, Rafael A da Silva4,5, Isabel Maria V G de Carvalho4,5, Dennis A Bertolini2.
Abstract
Phylogenetic studies with Zika virus (ZIKV) have been conducted in Brazil. In this study, we sequenced 8 new sequences of the ZIKV envelope (E) gene from strains of cases from the Paraná and Mato Grosso do Sul states in 2016. A low phylogenetic signal was observed, with more than 40% of unresolved quartets, and the Maximum Likelihood Tree grouped all sequences in the Brazilian branches within the Asian genotype. In addition, a Shannon entropy analysis was conducted, showing a high stability in the E protein through the ZIKV polyprotein. Taken together, these results suggest a high degree of conservation in the ZIKV E gene from the recent American outbreaks.Entities:
Keywords: Brazil; Entropy; Phylogenetic study; Zika virus
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Year: 2020 PMID： 32749573 PMCID： PMC7688768 DOI： 10.1007/s42770-020-00349-3
Source DB: PubMed Journal: Braz J Microbiol ISSN： 1517-8382 Impact factor: 2.476