Sharon K Davis1, Ruihua Xu1, Rumana J Khan1, Amadou Gaye2. 1. National Institutes of Health, National Human Genome Research Institute, Social Epidemiology Research Unit, Bethesda, MD. 2. National Institutes of Health, National Human Genome Research Institute, Cardiovascular Section, Bethesda, MD.
Abstract
Objective: Little is known about the relationship between adiposity and telomere length in the United States population. The objective of our research was to examine this relationship in a representative, socioeconomically and sex-specific, diverse racial/ethnic population in the United States. Methods: Body mass index (BMI), % total body fat (TBF) and waist circumference (WC) with leukocyte telomere length (LTL) were examined according to sex-specific race/ethnicity using separate adjusted multivariate linear regressions on a sample of 4,919 respondents aged 20-84 years from the National Health and Nutrition Examination Survey's 1999-2002 data. Results: LTL was shortened .41%, .44%, and .16% in African American (AA) women and was associated with increasing BMI, %TBF, and WC, (β:-.0041, 95%CI: -.0070, -.0012; P=.007; β:-.0044, 95% CI: -.0081, -.0007; P=.02; β:-.0016, 95%CI: -.0031, -.0001; P=.04, respectively). LTL was shortened .29% in White women and was associated with increasing %TBF (β:-.0029, 95%CI: -.0048, -.0009; P=.006). There were no associations among AA men, White men or Mexican American men and women. Conclusions: LTL is associated with an obesity phenotype in AA women. Tailored intervention is needed to ameliorate the burden of excess adiposity and subsequent cellular aging.
Objective: Little is known about the relationship between adiposity and telomere length in the United States population. The objective of our research was to examine this relationship in a representative, socioeconomically and sex-specific, diverse racial/ethnic population in the United States. Methods: Body mass index (BMI), % total body fat (TBF) and waist circumference (WC) with leukocyte telomere length (LTL) were examined according to sex-specific race/ethnicity using separate adjusted multivariate linear regressions on a sample of 4,919 respondents aged 20-84 years from the National Health and Nutrition Examination Survey's 1999-2002 data. Results: LTL was shortened .41%, .44%, and .16% in African American (AA) women and was associated with increasing BMI, %TBF, and WC, (β:-.0041, 95%CI: -.0070, -.0012; P=.007; β:-.0044, 95% CI: -.0081, -.0007; P=.02; β:-.0016, 95%CI: -.0031, -.0001; P=.04, respectively). LTL was shortened .29% in White women and was associated with increasing %TBF (β:-.0029, 95%CI: -.0048, -.0009; P=.006). There were no associations among AA men, White men or Mexican American men and women. Conclusions: LTL is associated with an obesity phenotype in AA women. Tailored intervention is needed to ameliorate the burden of excess adiposity and subsequent cellular aging.
Authors: O T Njajou; R M Cawthon; E H Blackburn; T B Harris; R Li; J L Sanders; A B Newman; M Nalls; S R Cummings; W-C Hsueh Journal: Int J Obes (Lond) Date: 2011-10-18 Impact factor: 5.095
Authors: Annette L Fitzpatrick; Richard A Kronmal; Jeffrey P Gardner; Bruce M Psaty; Nancy S Jenny; Russell P Tracy; Jeremy Walston; Masyuki Kimura; Abraham Aviv Journal: Am J Epidemiol Date: 2006-10-16 Impact factor: 4.897
Authors: J A Batsis; T A Mackenzie; E Vasquez; C M Germain; R T Emeny; P Rippberger; F Lopez-Jimenez; S J Bartels Journal: Int J Obes (Lond) Date: 2017-08-16 Impact factor: 5.095
Authors: Julia Raschenberger; Barbara Kollerits; Stephanie Titze; Anna Köttgen; Barbara Bärthlein; Arif B Ekici; Lukas Forer; Sebastian Schönherr; Hansi Weissensteiner; Margot Haun; Christoph Wanner; Kai-Uwe Eckardt; Florian Kronenberg Journal: Exp Gerontol Date: 2015-09-28 Impact factor: 4.032
Authors: Muhammad Hammadah; Ibhar Al Mheid; Kobina Wilmot; Ronnie Ramadan; Naser Abdelhadi; Ayman Alkhoder; Malik Obideen; Pratik M Pimple; Oleksiy Levantsevych; Heval M Kelli; Amit Shah; Yan V Sun; Brad Pearce; Michael Kutner; Qi Long; Laura Ward; Yi-An Ko; Kareem Hosny Mohammed; Jue Lin; Jinying Zhao; J Douglas Bremner; Jinhee Kim; Edmund K Waller; Paolo Raggi; David Sheps; Arshed A Quyyumi; Viola Vaccarino Journal: Circ Res Date: 2016-12-12 Impact factor: 17.367
Authors: David H Rehkopf; Belinda L Needham; Jue Lin; Elizabeth H Blackburn; Ami R Zota; Janet M Wojcicki; Elissa S Epel Journal: PLoS Med Date: 2016-11-29 Impact factor: 11.069
Authors: Caitlin Mason; Rosa-Ana Risques; Liren Xiao; Catherine R Duggan; Ikuyo Imayama; Kristin L Campbell; Angela Kong; Karen E Foster-Schubert; C Y Wang; Catherine M Alfano; George L Blackburn; Peter S Rabinovitch; Anne McTiernan Journal: Obesity (Silver Spring) Date: 2013-07-29 Impact factor: 5.002