Andrea Romanos-Nanclares1, Estefanía Toledo2, Rodrigo Sánchez-Bayona3, Cristina Sánchez-Quesada4, Miguel Ángel Martínez-González5, Alfredo Gea6. 1. University of Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. 2. University of Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. Electronic address: etoledo@unav.es. 3. University of Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; Department of Oncology, University of Navarra, Clínica Universidad de Navarra, Pamplona, Spain. 4. Department of Health Sciences, Faculty of Experimental Sciences, University of Jaen, Jaen, Spain. 5. University of Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 6. University of Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
Abstract
OBJECTIVES: Provegetarian diets, also known as predominantly plant-based (but not vegetarian or vegan) or plant-forward diets, have been associated with health benefits. However, a distinction is needed between high- and low-quality provegetarian dietary patterns (PVGs). We sought to examine potential associations between PVG indices and breast cancer (BC) incidence. METHODS: We assessed 10 812 women in the Seguimiento Universidad de Navarra cohort. We calculated an overall PVG pattern from a validated semi-quantitative food-frequency questionnaire as proposed by Martínez-Gonzalez et al, assigning positive scores (based on quintiles) to plant foods and reversing the quintile scores for animal foods. Participants were categorized according to tertiles of the overall score. We also calculated a healthful PVG (hPVG) and unhealthful PVG (uPVG) as proposed by Satija et al. RESULTS: After a median of 11.5 years of follow-up, 101 incident BC cases, confirmed by medical records, were observed. A significant inverse association with BC (comparing tertile 2 vs. tertile 1, HR= 0.55; 95% confidence interval, 0.32-0.95) was identified for a modest overall PVG, but not for hPVG and uPVG separately. Nevertheless, the highest tertile was not associated with BC. CONCLUSIONS: In this large prospective cohort study, a moderate adherence to a PVG might decrease the risk of BC. Further studies should replicate and expand these results to other racial, ethnic, and socioeconomic groups.
OBJECTIVES: Provegetarian diets, also known as predominantly plant-based (but not vegetarian or vegan) or plant-forward diets, have been associated with health benefits. However, a distinction is needed between high- and low-quality provegetarian dietary patterns (PVGs). We sought to examine potential associations between PVG indices and breast cancer (BC) incidence. METHODS: We assessed 10 812 women in the Seguimiento Universidad de Navarra cohort. We calculated an overall PVG pattern from a validated semi-quantitative food-frequency questionnaire as proposed by Martínez-Gonzalez et al, assigning positive scores (based on quintiles) to plant foods and reversing the quintile scores for animal foods. Participants were categorized according to tertiles of the overall score. We also calculated a healthful PVG (hPVG) and unhealthful PVG (uPVG) as proposed by Satija et al. RESULTS: After a median of 11.5 years of follow-up, 101 incident BC cases, confirmed by medical records, were observed. A significant inverse association with BC (comparing tertile 2 vs. tertile 1, HR= 0.55; 95% confidence interval, 0.32-0.95) was identified for a modest overall PVG, but not for hPVG and uPVG separately. Nevertheless, the highest tertile was not associated with BC. CONCLUSIONS: In this large prospective cohort study, a moderate adherence to a PVG might decrease the risk of BC. Further studies should replicate and expand these results to other racial, ethnic, and socioeconomic groups.
Authors: Shan Xuan Lim; See Ling Loy; Marjorelee T Colega; Jun Shi Lai; Keith M Godfrey; Yung Seng Lee; Kok Hian Tan; Fabian Yap; Lynette Pei-Chi Shek; Yap Seng Chong; Johan G Eriksson; Jerry Kok Yen Chan; Shiao-Yng Chan; Mary Foong-Fong Chong Journal: Am J Clin Nutr Date: 2022-02-09 Impact factor: 8.472
Authors: Ijeamaka C Anyene; Isaac J Ergas; Marilyn L Kwan; Janise M Roh; Christine B Ambrosone; Lawrence H Kushi; Elizabeth M Cespedes Feliciano Journal: Nutrients Date: 2021-09-25 Impact factor: 5.717
Authors: Andrea Romanos-Nanclares; Walter C Willett; Bernard A Rosner; Laura C Collins; Frank B Hu; Estefania Toledo; A Heather Eliassen Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-07-21 Impact factor: 4.254