Literature DB >> 32729059

Emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in KPC-2-producing Klebsiella pneumoniae of sequence type 39 during treatment.

Irene Galani1,2, Ilias Karaiskos3, Evdokia Angelidis4, Vassiliki Papoutsaki3, Lamprini Galani3, Maria Souli5, Anastasia Antoniadou4, Helen Giamarellou3.   

Abstract

Three ceftazidime-avibactam-resistant KPC-2-producing Klebsiella pneumoniae strains of ST39 were isolated in Greece, from rectal swabs of three patients after 10-15 days of treatment. The patients were treated with ceftazidime-avibactam as monotherapy or in combination with colistin. Two of these strains harbored a D179Y or a D179V substitution in the Ω loop of KPC-2, corresponding to KPC-33, or to the novel KPC-57, respectively. The third strain had a 15 amino acid insertion after position 259 in the KPC-2, corresponding to KPC-44.

Entities:  

Keywords:  Ceftazidime-avibactam; K. pneumoniae; KPC-2; KPC-33; KPC-44; KPC-57 (D179V)

Mesh：

Substances：

Year:  2020        PMID： 32729059     DOI： 10.1007/s10096-020-04000-9

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  15 in total

1.  Fecal carriage of carbapenemase-producing Enterobacteriaceae: a hidden reservoir in hospitalized and nonhospitalized patients.

Authors:  Desirèe Gijón; Tânia Curiao; Fernando Baquero; Teresa M Coque; Rafael Cantón
Journal:  J Clin Microbiol       Date:  2012-03-07       Impact factor: 5.948

2.  Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.

Authors:  A-P Magiorakos; A Srinivasan; R B Carey; Y Carmeli; M E Falagas; C G Giske; S Harbarth; J F Hindler; G Kahlmeter; B Olsson-Liljequist; D L Paterson; L B Rice; J Stelling; M J Struelens; A Vatopoulos; J T Weber; D L Monnet
Journal:  Clin Microbiol Infect       Date:  2011-07-27       Impact factor: 8.067

3.  Emergence of ST39 and ST656 extensively drug-resistant Klebsiella pneumoniae isolates in Wenzhou, China.

Authors:  Haiyang Liu; Jonathan Wilksch; Bin Li; Jia Du; Jianming Cao; Xiaoxiao Zhang; Tieli Zhou
Journal:  Indian J Med Microbiol       Date:  2017 Jan-Mar       Impact factor: 0.985

4.  Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the Detection of IMP Variants Previously Undetected.

Authors:  Hervé Volland; Delphine Girlich; Marine Laguide; Camille Gonzalez; Virginie Paris; Maxime Laroche; Saoussen Oueslati; Laurent Dortet; Stéphanie Simon; Thierry Naas
Journal:  Antimicrob Agents Chemother       Date:  2019-12-20       Impact factor: 5.191

5.  Plasmid-mediated quinolone resistance determinants among Gram-negative bacteraemia isolates: a hidden threat.

Authors:  Athanasios Margaritis; Irene Galani; Marianthi Chatzikonstantinou; George Petrikkos; Maria Souli
Journal:  J Med Microbiol       Date:  2017-03-20       Impact factor: 2.472

6.  Whole-genome sequencing study of KPC-encoding Klebsiella pneumoniae isolated in Greek private laboratories from non-hospitalised patients.

Authors:  Georgios Meletis; Fani Chatzopoulou; Aikaterini Fragkouli; Magdalini Alexandridou; Ilias Mavrovouniotis; Anastasia Chatzinikolaou; Dimitrios Chatzidimitriou
Journal:  J Glob Antimicrob Resist       Date:  2019-08-04       Impact factor: 4.035

7.  Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.

Authors:  Ryan K Shields; Liang Chen; Shaoji Cheng; Kalyan D Chavda; Ellen G Press; Avin Snyder; Ruchi Pandey; Yohei Doi; Barry N Kreiswirth; M Hong Nguyen; Cornelius J Clancy
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

8.  Successive Emergence of Ceftazidime-Avibactam Resistance through Distinct Genomic Adaptations in blaKPC-2-Harboring Klebsiella pneumoniae Sequence Type 307 Isolates.

Authors:  Marla J Giddins; Nenad Macesic; Medini K Annavajhala; Stephania Stump; Sabrina Khan; Thomas H McConville; Monica Mehta; Angela Gomez-Simmonds; Anne-Catrin Uhlemann
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

9.  Outbreak of an armA methyltransferase-producing ST39 Klebsiella pneumoniae clone in a pediatric Algerian Hospital.

Authors:  Zineb Belbel; Houria Chettibi; Mazouz Dekhil; Ali Ladjama; Sabrina Nedjai; Jean-Marc Rolain
Journal:  Microb Drug Resist       Date:  2014-01-29       Impact factor: 3.431

10.  IS26-Mediated Transfer of bla NDM-1 as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital.

Authors:  Robert E Weber; Michael Pietsch; Andre Frühauf; Yvonne Pfeifer; Maria Martin; Dirk Luft; Sören Gatermann; Niels Pfennigwerth; Martin Kaase; Guido Werner; Stephan Fuchs
Journal:  Front Microbiol       Date:  2019-12-17       Impact factor: 5.640
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  8 in total

1.  Multiple Novel Ceftazidime-Avibactam-Resistant Variants of blaKPC-2-Positive Klebsiella pneumoniae in Two Patients.

Authors:  Qingyu Shi; Renru Han; Yan Guo; Yang Yang; Shi Wu; Li Ding; Rong Zhang; Dandan Yin; Fupin Hu
Journal:  Microbiol Spectr       Date:  2022-05-19

2.  The Rapid Emergence of Ceftazidime-Avibactam Resistance Mediated by KPC Variants in Carbapenem-Resistant Klebsiella pneumoniae in Zhejiang Province, China.

Authors:  Congcong Liu; Yuchen Wu; Ling Huang; Yanyan Zhang; Qiaoling Sun; Jiayue Lu; Yu Zeng; Ning Dong; Chang Cai; Zhangqi Shen; Gongxiang Chen; Rong Zhang
Journal:  Antibiotics (Basel)       Date:  2022-05-30

3.  Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC β-Lactamase.

Authors:  Magdalena A Taracila; Christopher R Bethel; Andrea M Hujer; Krisztina M Papp-Wallace; Melissa D Barnes; Joseph D Rutter; Jamie VanPelt; Ben A Shurina; Focco van den Akker; Cornelius J Clancy; M Hong Nguyen; Shaoji Cheng; Ryan K Shields; Richard C Page; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2022-03-21       Impact factor: 5.938

4.  Increased gene expression and copy number of mutated blaKPC lead to high-level ceftazidime/avibactam resistance in Klebsiella pneumoniae.

Authors:  Lingxiao Sun; Haibo Li; Qi Wang; Yingmei Liu; Bin Cao
Journal:  BMC Microbiol       Date:  2021-08-19       Impact factor: 3.605

5.  Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant Klebsiella pneumoniae Strains.

Authors:  Yuchen Wu; Xuemei Yang; Congcong Liu; Yanyan Zhang; Yan Chu Cheung; Edward Wai Chi Chan; Sheng Chen; Rong Zhang
Journal:  Microbiol Spectr       Date:  2022-04-13

6.  Diversity of Ceftazidime-Avibactam Resistance Mechanism in KPC2-Producing Klebsiella pneumoniae Under Antibiotic Selection Pressure.

Authors:  Min Jiang; Bin Sun; Yong Huang; Chengyang Liu; Yan Wang; Yanli Ren; Yuhong Zhang; Yunying Wang; Di Mu
Journal:  Infect Drug Resist       Date:  2022-08-18       Impact factor: 4.177

7.  KPC-Mediated Resistance to Ceftazidime-Avibactam and Collateral Effects in Klebsiella pneumoniae.

Authors:  Jacqueline Findlay; Laurent Poirel; Mario Juhas; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2021-08-17       Impact factor: 5.191

Review 8.  Nosocomial Pneumonia in the Era of Multidrug-Resistance: Updates in Diagnosis and Management.

Authors:  Elena Xu; David Pérez-Torres; Paraskevi C Fragkou; Jean-Ralph Zahar; Despoina Koulenti
Journal:  Microorganisms       Date:  2021-03-05
  8 in total

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