This document provides supplementary guidance on specific topics for the allergenicity risk assessment of genetically modified plants. In particular, it supplements general recommendations outlined in previous EFSA GMO Panel guidelines and Implementing Regulation (EU) No 503/2013. The topics addressed are non-IgE-mediated adverse immune reactions to foods, in vitro protein digestibility tests and endogenous allergenicity. New scientific and regulatory developments regarding these three topics are described in this document. Considerations on the practical implementation of those developments in the risk assessment of genetically modified plants are discussed and recommended, where appropriate.
This document provides supplepan class="Species">mentary guidance on specific topics for the allergenicity risk assessment of genetically modified plants. In particular, it supplements general recommendations outlined in previous EFSAGMO Panel guidelines and Implementing Regulation (EU) No 503/2013. The topics addressed are non-IgE-mediated adverse immune reactions to foods, in vitro protein digestibility tests and endogenous allergenicity. New scientific and regulatory developments regarding these three topics are described in this document. Considerations on the practical implementation of those developments in the risk assessment of genetically modified plants are discussed and recommended, where appropriate.
Authors: A König; A Cockburn; R W R Crevel; E Debruyne; R Grafstroem; U Hammerling; I Kimber; I Knudsen; H A Kuiper; A A C M Peijnenburg; A H Penninks; M Poulsen; M Schauzu; J M Wal Journal: Food Chem Toxicol Date: 2004-07 Impact factor: 6.023
Authors: Jason A Tye-Din; Jessica A Stewart; James A Dromey; Tim Beissbarth; David A van Heel; Arthur Tatham; Kate Henderson; Stuart I Mannering; Carmen Gianfrani; Derek P Jewell; Adrian V S Hill; James McCluskey; Jamie Rossjohn; Robert P Anderson Journal: Sci Transl Med Date: 2010-07-21 Impact factor: 17.956
Authors: R W R Crevel; B K Ballmer-Weber; T Holzhauser; J O'B Hourihane; A C Knulst; A R Mackie; F Timmermans; S L Taylor Journal: Allergy Date: 2008-05 Impact factor: 13.146
Authors: Hanspeter Naegeli; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Ewen Mullins; Fabien Nogué; Nils Rostoks; Jose Juan Sánchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Fernando Álvarez; Michele Ardizzone; Giacomo De Sanctis; Antonio Fernandez; Andrea Gennaro; Jose Ángel Gómez Ruiz; Dafni Maria Kagkli; Anna Lanzoni; Franco Maria Neri; Nikoletta Papadopoulou; Konstantinos Paraskevopoulos; Tommaso Raffaello Journal: EFSA J Date: 2021-01-19
Authors: Ewen Mullins; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Fabien Nogue; Nils Rostoks; Jose Juan Sanchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Josep Casacuberta; Matias D Zurbriggen; Antonio Fernandez; Jose Angel Gomez Ruiz; Andrea Gennaro; Nikoletta Papadopoulou; Anna Lanzoni; Hanspeter Naegeli Journal: EFSA J Date: 2022-07-20
Authors: Plaimein Amnuaycheewa; Mohamed Abdelmoteleb; John Wise; Barbara Bohle; Fatima Ferreira; Afua O Tetteh; Steve L Taylor; Richard E Goodman Journal: Front Allergy Date: 2022-05-26
Authors: Hanspeter Naegeli; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Ewen Mullins; Fabien Nogué; Nils Rostoks; Jose Juan Sánchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Michele Ardizzone; Yann Devos; Silvia Federici; Antonio Fernandez Dumont; Andrea Gennaro; Jose Ángel Gómez Ruiz; Franco Maria Neri; Nikoletta Papadopoulou; Konstantinos Paraskevopoulos; Anna Lanzoni Journal: EFSA J Date: 2021-06-17
Authors: Rod A Herman; Patricia A Bauman; Laurie Goodwin; Emir Islamovic; Eric H Ma; Hector Serrano; Andre Silvanovich; Abigail R Simmons; Ping Song; Afua O Tetteh; Rong Wang Journal: Transgenic Res Date: 2021-04-16 Impact factor: 2.788
Authors: Hanspeter Naegeli; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Ewen Mullins; Fabien Nogué; Nils Rostoks; Jose Juan Sánchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Fernando Álvarez; Michele Ardizzone; Tommaso Raffaello Journal: EFSA J Date: 2021-07-07