Literature DB >> 32728397

Guidance on allergenicity assessment of genetically modified plants.

Hanspeter Naegeli, Andrew Nicholas Birch, Josep Casacuberta, Adinda De Schrijver, Mikolaj Antoni Gralak, Philippe Guerche, Huw Jones, Barbara Manachini, Antoine Messéan, Elsa Ebbesen Nielsen, Fabien Nogué, Christophe Robaglia, Nils Rostoks, Jeremy Sweet, Christoph Tebbe, Francesco Visioli, Jean-Michel Wal, Philippe Eigenmann, Michelle Epstein, Karin Hoffmann-Sommergruber, Frits Koning, Martinus Lovik, Clare Mills, Francisco Javier Moreno, Henk van Loveren, Regina Selb, Antonio Fernandez Dumont.   

Abstract

This document provides supplementary guidance on specific topics for the allergenicity risk assessment of genetically modified plants. In particular, it supplements general recommendations outlined in previous EFSA GMO Panel guidelines and Implementing Regulation (EU) No 503/2013. The topics addressed are non-IgE-mediated adverse immune reactions to foods, in vitro protein digestibility tests and endogenous allergenicity. New scientific and regulatory developments regarding these three topics are described in this document. Considerations on the practical implementation of those developments in the risk assessment of genetically modified plants are discussed and recommended, where appropriate.
© 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Entities:  

Keywords:  GMO; allergenicity assessment; endogenous allergenicity; guidance; newly expressed proteins

Year:  2017        PMID： 32728397      PMCID： PMC7384481          DOI： 10.2903/j.efsa.2017.4862

Source DB:  PubMed          Journal:  EFSA J        ISSN： 1831-4732


  17 in total

Review 1.  Genetics of wheat gluten proteins.

Authors:  Peter R Shewry; Nigel G Halford; Domenico Lafiandra
Journal:  Adv Genet       Date:  2003       Impact factor: 1.944

Review 2.  Assessment of the safety of foods derived from genetically modified (GM) crops.

Authors:  A König; A Cockburn; R W R Crevel; E Debruyne; R Grafstroem; U Hammerling; I Kimber; I Knudsen; H A Kuiper; A A C M Peijnenburg; A H Penninks; M Poulsen; M Schauzu; J M Wal
Journal:  Food Chem Toxicol       Date:  2004-07       Impact factor: 6.023

3.  Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.

Authors:  Jason A Tye-Din; Jessica A Stewart; James A Dromey; Tim Beissbarth; David A van Heel; Arthur Tatham; Kate Henderson; Stuart I Mannering; Carmen Gianfrani; Derek P Jewell; Adrian V S Hill; James McCluskey; Jamie Rossjohn; Robert P Anderson
Journal:  Sci Transl Med       Date:  2010-07-21       Impact factor: 17.956

Review 4.  Integration of genetic and immunological insights into a model of celiac disease pathogenesis.

Authors:  Valérie Abadie; Ludvig M Sollid; Luis B Barreiro; Bana Jabri
Journal:  Annu Rev Immunol       Date:  2011       Impact factor: 28.527

Review 5.  Celiac disease.

Authors:  Peter H R Green; Christophe Cellier
Journal:  N Engl J Med       Date:  2007-10-25       Impact factor: 91.245

6.  Endogenous allergens and compositional analysis in the allergenicity assessment of genetically modified plants.

Authors:  A Fernandez; E N C Mills; M Lovik; A Spoek; A Germini; A Mikalsen; J M Wal
Journal:  Food Chem Toxicol       Date:  2013-08-16       Impact factor: 6.023

Review 7.  Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens.

Authors:  Frits Koning; Ranjeny Thomas; Jamie Rossjohn; Rene E Toes
Journal:  Nat Rev Rheumatol       Date:  2015-05-19       Impact factor: 20.543

Review 8.  Thresholds for food allergens and their value to different stakeholders.

Authors:  R W R Crevel; B K Ballmer-Weber; T Holzhauser; J O'B Hourihane; A C Knulst; A R Mackie; F Timmermans; S L Taylor
Journal:  Allergy       Date:  2008-05       Impact factor: 13.146

Review 9.  Role of oats in celiac disease.

Authors:  Isabel Comino; María de Lourdes Moreno; Carolina Sousa
Journal:  World J Gastroenterol       Date:  2015-11-07       Impact factor: 5.742

Review 10.  Local communication among mucosal immune cells in patients with celiac disease.

Authors:  Jeroen van Bergen; Chris J Mulder; M Luisa Mearin; Frits Koning
Journal:  Gastroenterology       Date:  2015-01-24       Impact factor: 22.682
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  28 in total

1.  Assessment of genetically modified maize MON 87427 × MON 87460 × MON 89034 × 1507 × MON 87411 × 59122 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2017-139).

Authors:  Hanspeter Naegeli; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Ewen Mullins; Fabien Nogué; Nils Rostoks; Jose Juan Sánchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Fernando Álvarez; Michele Ardizzone; Giacomo De Sanctis; Antonio Fernandez; Andrea Gennaro; Jose Ángel Gómez Ruiz; Dafni Maria Kagkli; Anna Lanzoni; Franco Maria Neri; Nikoletta Papadopoulou; Konstantinos Paraskevopoulos; Tommaso Raffaello
Journal:  EFSA J       Date:  2021-01-19

2.  Evaluation of existing guidelines for their adequacy for the food and feed risk assessment of microorganisms obtained through synthetic biology.

Authors:  Simon More; Vasileios Bampidis; Diane Benford; Claude Bragard; Thorhallur Halldorsson; Antonio Hernández-Jerez; Susanne Hougaard Bennekou; Kostas Koutsoumanis; Claude Lambré; Kyriaki Machera; Ewen Mullins; Søren Saxmose Nielsen; Josef Schlatter; Dieter Schrenk; Dominique Turck; Maged Younes; Lieve Herman; Carmen Pelaez; Henk van Loveren; Just Vlak; Joana Revez; Jaime Aguilera; Reinhilde Schoonjans; Pier Sandro Cocconcelli
Journal:  EFSA J       Date:  2022-08-16

3.  Evaluation of existing guidelines for their adequacy for the food and feed risk assessment of genetically modified plants obtained through synthetic biology.

Authors:  Ewen Mullins; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Fabien Nogue; Nils Rostoks; Jose Juan Sanchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Josep Casacuberta; Matias D Zurbriggen; Antonio Fernandez; Jose Angel Gomez Ruiz; Andrea Gennaro; Nikoletta Papadopoulou; Anna Lanzoni; Hanspeter Naegeli
Journal:  EFSA J       Date:  2022-07-20

4.  Development of a Sequence Searchable Database of Celiac Disease-Associated Peptides and Proteins for Risk Assessment of Novel Food Proteins.

Authors:  Plaimein Amnuaycheewa; Mohamed Abdelmoteleb; John Wise; Barbara Bohle; Fatima Ferreira; Afua O Tetteh; Steve L Taylor; Richard E Goodman
Journal:  Front Allergy       Date:  2022-05-26

5.  Assessment of genetically modified oilseed rape 73496 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2012-109).

Authors:  Hanspeter Naegeli; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Ewen Mullins; Fabien Nogué; Nils Rostoks; Jose Juan Sánchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Michele Ardizzone; Yann Devos; Silvia Federici; Antonio Fernandez Dumont; Andrea Gennaro; Jose Ángel Gómez Ruiz; Franco Maria Neri; Nikoletta Papadopoulou; Konstantinos Paraskevopoulos; Anna Lanzoni
Journal:  EFSA J       Date:  2021-06-17

6.  Mass spectrometric analysis of digesta does not improve the allergenicity assessment of GM crops.

Authors:  Rod A Herman; Patricia A Bauman; Laurie Goodwin; Emir Islamovic; Eric H Ma; Hector Serrano; Andre Silvanovich; Abigail R Simmons; Ping Song; Afua O Tetteh; Rong Wang
Journal:  Transgenic Res       Date:  2021-04-16       Impact factor: 2.788

7.  Safety evaluation of the food enzyme alternansucrase from Leuconostoc citreum strain NRRL B-30894.

Authors:  Vittorio Silano; José Manuel Barat Baviera; Claudia Bolognesi; Pier Sandro Cocconcelli; Riccardo Crebelli; David Michael Gott; Konrad Grob; Claude Lambré; Evgenia Lampi; Marcel Mengelers; Alicja Mortensen; Gilles Rivière; Inger-Lise Steffensen; Christina Tlustos; Henk Van Loveren; Laurence Vernis; Holger Zorn; Boet Glandorf; Lieve Herman; André Penninks; Jaime Aguilera; Margarita Aguilera-Gomez; Magdalena Andryszkiewicz; Natália Kovalkovičová; Yi Liu; Claudia Roncancio Peña; Andrew Chesson
Journal:  EFSA J       Date:  2021-01-19

8.  Assessment of genetically modified cotton GHB614 for renewal authorisation under Regulation (EC) No 1829/2003 (application EFSA-GMO-RX-018).

Authors:  Hanspeter Naegeli; Jean-Louis Bresson; Tamas Dalmay; Ian Crawford Dewhurst; Michelle M Epstein; Leslie George Firbank; Philippe Guerche; Jan Hejatko; Francisco Javier Moreno; Ewen Mullins; Fabien Nogué; Nils Rostoks; Jose Juan Sánchez Serrano; Giovanni Savoini; Eve Veromann; Fabio Veronesi; Fernando Álvarez; Michele Ardizzone; Tommaso Raffaello
Journal:  EFSA J       Date:  2021-07-07

9.  Trypsin cleavage sites are highly unlikely to occur in celiac-causing restricted epitopes.

Authors:  Rod A Herman; Ping Song; Henry P Mirsky
Journal:  GM Crops Food       Date:  2019-11-19       Impact factor: 3.074

10.  Allergen false-detection using official bioinformatic algorithms.

Authors:  Rod A Herman; Ping Song
Journal:  GM Crops Food       Date:  2020-01-06       Impact factor: 3.074
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