Jiajia Qu1, Lap Kam Chang2, Xinghua Tang1, Yiming Du3, Xi Yang4, Xiangjiao Liu5, Ping Han6, Yuwen Xue1. 1. Department of Pulmonary and Critical Care Medicine, Shandong University Qilu Hospital , Jinan, China. 2. Department of international student, Shandong University Cheeloo College of Medicine , Jinan, China. 3. Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University , Jinan, China. 4. Department of Pulmonary and Critical Care Medicine, Taizhou Central Hospital (Taizhou University Hospital) , Taizhou, China. 5. Department of Pulmonary and Critical Care Medicine, Feixian People's Hospital , Linyi, China. 6. Department of Pulmonary and Critical Care Medicine, Linyi People's Hospital , Linyi, China.
Abstract
OBJECTIVES: To recognise clinical features of COVID-19 pneumonia and its differences from influenza pneumonia. METHODS: 246 patients were enrolled into COVID-19 cohort and 120 patients into influenza cohort. All data were collected and analysed retrospectively. The variables under focus included demographic, epidemiological, clinical, laboratory and imaging characteristics of COVID-19 pneumonia and comparison were made with influenza pneumonia. RESULTS: The COVID-19 cohort included 53.25% female and 46.75% male. Their main symptom was fever; while 28.05% of patients had only initially fever; 21.54% of them remained feverless. After excluding prior kidney diseases, some patients showed abnormal urinalysis (32.11%), elevated blood creatinine (15.04%) and blood urea nitrogen (19.11%). Typical CT features included ground glass opacity, consolidation and band opacity, which could present as characteristic 'bat wing sign'. Our data showed that male, aged 65 or above, smoking, with comorbidities including diabetes, cardiovascular and kidney diseases, would experience more severe COVID-19 pneumonia. In comparison, COVID-19 cohort showed significantly higher incidence of clustering; the influenza cohort showed higher rate of fever. Both cohorts showed reduced lymphocyte numbers; however, 6 influenza patients showed lymphocytes increased, which was statistical significant compared with COVID-19 cohort. Also, influenza cohort displayed higher white blood cell counts and PCT values. CONCLUSION: There is no significant gender difference in the incidence of COVID-19 pneumonia. It predominantly affects the lung as well as the kidney. Age, smoking and comorbidities could contribute to disease severity. Although COVID-19 is more infectious, the rate of secondary bacterial infection is lower than influenza.
OBJECTIVES: To recognise clinical features of COVID-19 pneumonia and its differences from influenza pneumonia. METHODS: 246 patients were enrolled into COVID-19 cohort and 120 patients into influenza cohort. All data were collected and analysed retrospectively. The variables under focus included demographic, epidemiological, clinical, laboratory and imaging characteristics of COVID-19 pneumonia and comparison were made with influenza pneumonia. RESULTS: The COVID-19 cohort included 53.25% female and 46.75% male. Their main symptom was fever; while 28.05% of patients had only initially fever; 21.54% of them remained feverless. After excluding prior kidney diseases, some patients showed abnormal urinalysis (32.11%), elevated blood creatinine (15.04%) and blood ureanitrogen (19.11%). Typical CT features included ground glass opacity, consolidation and band opacity, which could present as characteristic 'bat wing sign'. Our data showed that male, aged 65 or above, smoking, with comorbidities including diabetes, cardiovascular and kidney diseases, would experience more severe COVID-19 pneumonia. In comparison, COVID-19 cohort showed significantly higher incidence of clustering; the influenza cohort showed higher rate of fever. Both cohorts showed reduced lymphocyte numbers; however, 6 influenza patients showed lymphocytes increased, which was statistical significant compared with COVID-19 cohort. Also, influenza cohort displayed higher white blood cell counts and PCT values. CONCLUSION: There is no significant gender difference in the incidence of COVID-19 pneumonia. It predominantly affects the lung as well as the kidney. Age, smoking and comorbidities could contribute to disease severity. Although COVID-19 is more infectious, the rate of secondary bacterial infection is lower than influenza.
Authors: Andrej Romanov; Michael Bach; Shan Yang; Fabian C Franzeck; Gregor Sommer; Constantin Anastasopoulos; Jens Bremerich; Bram Stieltjes; Thomas Weikert; Alexander Walter Sauter Journal: Diagnostics (Basel) Date: 2021-04-21
Authors: Stefan Kluge; Julian Schulze Zur Wiesch; Thomas Theo Brehm; Marc van der Meirschen; Annette Hennigs; Kevin Roedl; Dominik Jarczak; Dominic Wichmann; Daniel Frings; Axel Nierhaus; Tim Oqueka; Walter Fiedler; Maximilian Christopeit; Christian Kraef; Alexander Schultze; Marc Lütgehetmann; Marylyn M Addo; Stefan Schmiedel Journal: Sci Rep Date: 2021-03-11 Impact factor: 4.379