Mengting Ji1, Jiujie Cui1, Huiqin Xi2, Yan Yang2, Liwei Wang1. 1. Oncology Department, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 2. Nursing Department, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Abstract
BACKGROUND: Cancer patients always experience an ongoing deterioration in health-related quality of life (HRQoL). There is a strengthening awareness of health care professionals of taking HRQoL, which is a patient-reported outcome measures (PROMs), into consideration when they make an adequate selection in clinical practice. Olanzapine, an antipsychotic agent, has been demonstrated to be a safe and effective agent in improving cancer-related symptoms. AIM: To review the efficacy and safety of olanzapine in improving HRQoL among adults with malignant tumor. METHODS: Eligible studies were retrieved from an electronic database search of the Cochrane, Medline, CINAHL plus, Pubmed, Embase, PsycINFO, Web of Science, and Scopus. The methodological quality of selected studies was evaluated, and the relevant data were extracted and synthesized. RESULTS: While studies differed in target population, olanzapine-based treatment regimen, and HRQoL measurement tools, results have shown that olanzapine has a positive impact on cancer patients' general HRQoL status, functional outcomes, and/or symptoms improvement. Besides, no serious toxicities attributable to olanzapine were observed in all studies included. CONCLUSION: While further studies are needed especially which adopted the HRQoL as primary outcome through comprehensive measures, olanzapine could still be recommended in the palliative care.
BACKGROUND:Cancerpatients always experience an ongoing deterioration in health-related quality of life (HRQoL). There is a strengthening awareness of health care professionals of taking HRQoL, which is a patient-reported outcome measures (PROMs), into consideration when they make an adequate selection in clinical practice. Olanzapine, an antipsychotic agent, has been demonstrated to be a safe and effective agent in improving cancer-related symptoms. AIM: To review the efficacy and safety of olanzapine in improving HRQoL among adults with malignant tumor. METHODS: Eligible studies were retrieved from an electronic database search of the Cochrane, Medline, CINAHL plus, Pubmed, Embase, PsycINFO, Web of Science, and Scopus. The methodological quality of selected studies was evaluated, and the relevant data were extracted and synthesized. RESULTS: While studies differed in target population, olanzapine-based treatment regimen, and HRQoL measurement tools, results have shown that olanzapine has a positive impact on cancerpatients' general HRQoL status, functional outcomes, and/or symptoms improvement. Besides, no serious toxicities attributable to olanzapine were observed in all studies included. CONCLUSION: While further studies are needed especially which adopted the HRQoL as primary outcome through comprehensive measures, olanzapine could still be recommended in the palliative care.
Authors: David E Barajas Galindo; Alfonso Vidal-Casariego; Alicia Calleja-Fernández; Ana Hernández-Moreno; Begoña Pintor de la Maza; Manuela Pedraza-Lorenzo; María Asunción Rodríguez-García; Dalia María Ávila-Turcios; Miran Alejo-Ramos; Rocío Villar-Taibo; Ana Urioste-Fondo; Isidoro Cano-Rodríguez; María D Ballesteros-Pomar Journal: Appetite Date: 2017-03-16 Impact factor: 3.868
Authors: Janneke van Roij; Heidi Fransen; Lonneke van de Poll-Franse; Myrte Zijlstra; Natasja Raijmakers Journal: Qual Life Res Date: 2018-02-10 Impact factor: 4.147