Literature DB >> 32716425

Iron Fenton oxidation of 2'-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical.

Aaron M Fleming1, Cynthia J Burrows1.   

Abstract

Product analysis from the iron Fenton oxidation of 2'-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2'-deoxyguanosine and spiroiminodihyantoin consistent with CO3˙-. Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO˙. These observations change the view of DNA oxidation products from the iron-Fenton reaction.

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Year:  2020        PMID： 32716425      PMCID： PMC7545335          DOI： 10.1039/d0cc04138f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  31 in total

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5.  Measurement of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxo-7,8-dihydroguanine in isolated DNA exposed to gamma radiation in aqueous solution.

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Journal:  Carcinogenesis       Date:  1997-12       Impact factor: 4.944

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Review 7.  One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA.

Authors:  Jean Cadet; J Richard Wagner; Vladimir Shafirovich; Nicholas E Geacintov
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8.  DNA sequence context as a determinant of the quantity and chemistry of guanine oxidation produced by hydroxyl radicals and one-electron oxidants.

Authors:  Yelena Margolin; Vladimir Shafirovich; Nicholas E Geacintov; Michael S DeMott; Peter C Dedon
Journal:  J Biol Chem       Date:  2008-10-23       Impact factor: 5.157

9.  Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.

Authors:  Paige L McKibbin; Aaron M Fleming; Mohammad Atif Towheed; Bennett Van Houten; Cynthia J Burrows; Sheila S David
Journal:  J Am Chem Soc       Date:  2013-09-05       Impact factor: 15.419

10.  Mechanistic aspects of hydration of guanine radical cations in DNA.

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3.  Epigenetic Marks, DNA Damage Markers, or Both? The Impact of Desiccation and Accelerated Aging on Nucleobase Modifications in Plant Genomic DNA.

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Review 6.  Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction.

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Review 7.  Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite-Derived Radicals.

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Review 8.  Hydroxyl radical is a significant player in oxidative DNA damage in vivo.

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9.  The Role of Carbonate in Catalytic Oxidations.

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  10 in total

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