Literature DB >> 32713288

Chloroquine in fighting COVID-19: good, bad, or both?

Daolin Tang1,2, Jingbo Li2, Ruoxi Zhang2, Rui Kang2, Daniel J Klionsky3.   

Abstract

Coronavirus disease 2019 (COVID-19) has attracted worldwide attention due to its speed of progression and elevated mortality rate. Amid the rush to develop treatments, recent hopes have focused on the anti-malarial drug chloroquine or the derivative hydroxychloroquine. Here, we briefly discuss the evidence for the potential use of these drugs with regard to the current pandemic.

Entities:  

Keywords:  COVID-19; Chloroquine; SARS-CoV-2; autophagy; clinical trial; hydroxychloroquine

Mesh：

Substances：

Year:  2020        PMID： 32713288      PMCID： PMC7751499          DOI： 10.1080/15548627.2020.1796014

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  21 in total

1.  Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

Authors:  Jianjun Gao; Zhenxue Tian; Xu Yang
Journal:  Biosci Trends       Date:  2020-02-19       Impact factor: 2.400

2.  [Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia].

Authors: 
Journal:  Zhonghua Jie He He Hu Xi Za Zhi       Date:  2020-02-20

3.  The COVID-19 vaccine development landscape.

Authors:  Tung Thanh Le; Zacharias Andreadakis; Arun Kumar; Raúl Gómez Román; Stig Tollefsen; Melanie Saville; Stephen Mayhew
Journal:  Nat Rev Drug Discov       Date:  2020-05       Impact factor: 84.694

4.  Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury.

Authors:  Hideo Yasuda; Asada Leelahavanichkul; Shinichiro Tsunoda; James W Dear; Yoshiyuki Takahashi; Shuichi Ito; Xuzhen Hu; Hua Zhou; Kent Doi; Richard Childs; Dennis M Klinman; Peter S T Yuen; Robert A Star
Journal:  Am J Physiol Renal Physiol       Date:  2008-02-27

5.  Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.

Authors:  Martin J Vincent; Eric Bergeron; Suzanne Benjannet; Bobbie R Erickson; Pierre E Rollin; Thomas G Ksiazek; Nabil G Seidah; Stuart T Nichol
Journal:  Virol J       Date:  2005-08-22       Impact factor: 4.099

6.  Chloroquine is a zinc ionophore.

Authors:  Jing Xue; Amanda Moyer; Bing Peng; Jinchang Wu; Bethany N Hannafon; Wei-Qun Ding
Journal:  PLoS One       Date:  2014-10-01       Impact factor: 3.240

7.  A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Authors:  Peng Zhou; Xing-Lou Yang; Xian-Guang Wang; Ben Hu; Lei Zhang; Wei Zhang; Hao-Rui Si; Yan Zhu; Bei Li; Chao-Lin Huang; Hui-Dong Chen; Jing Chen; Yun Luo; Hua Guo; Ren-Di Jiang; Mei-Qin Liu; Ying Chen; Xu-Rui Shen; Xi Wang; Xiao-Shuang Zheng; Kai Zhao; Quan-Jiao Chen; Fei Deng; Lin-Lin Liu; Bing Yan; Fa-Xian Zhan; Yan-Yi Wang; Geng-Fu Xiao; Zheng-Li Shi
Journal:  Nature       Date:  2020-02-03       Impact factor: 69.504

8.  Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.

Authors:  Manli Wang; Ruiyuan Cao; Leike Zhang; Xinglou Yang; Jia Liu; Mingyue Xu; Zhengli Shi; Zhihong Hu; Wu Zhong; Gengfu Xiao
Journal:  Cell Res       Date:  2020-02-04       Impact factor: 25.617

9.  Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.

Authors:  Philippe Colson; Jean-Marc Rolain; Jean-Christophe Lagier; Philippe Brouqui; Didier Raoult
Journal:  Int J Antimicrob Agents       Date:  2020-03-04       Impact factor: 5.283

10.  A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.

Authors:  Andrea Cortegiani; Giulia Ingoglia; Mariachiara Ippolito; Antonino Giarratano; Sharon Einav
Journal:  J Crit Care       Date:  2020-03-10       Impact factor: 3.425
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  7 in total

Review 1.  Autophagy in health and disease: From molecular mechanisms to therapeutic target.

Authors:  Guang Lu; Yu Wang; Yin Shi; Zhe Zhang; Canhua Huang; Weifeng He; Chuang Wang; Han-Ming Shen
Journal:  MedComm (2020)       Date:  2022-07-10

2.  A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19.

Authors:  Yongsheng Huang; Xiaoyu Lyu; Dan Li; Lin Wang; Yujun Wang; Wenbin Zou; Yingxin Wei; Xiaowei Wu
Journal:  PLoS One       Date:  2020-11-09       Impact factor: 3.240

3.  Impact of Treatment Regimens on Antibody Response to the SARS-CoV-2 Coronavirus.

Authors:  Yufeng Shang; Tao Liu; Jingfeng Li; Natasha Mupeta Kaweme; Xinghuan Wang; Fuling Zhou
Journal:  Front Immunol       Date:  2021-04-15       Impact factor: 7.561

4.  Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19.

Authors:  Xiuge Gao; Xian Jing; Junqi Wang; Yuling Zheng; Yawei Qiu; Hui Ji; Lin Peng; Shanxiang Jiang; Wenda Wu; Dawei Guo
Journal:  Chem Biol Interact       Date:  2022-04-22       Impact factor: 5.168

Review 5.  Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19.

Authors:  Weifeng He; Yuan Gao; Jing Zhou; Yi Shi; Dajing Xia; Han-Ming Shen
Journal:  Int J Biol Sci       Date:  2022-07-11       Impact factor: 10.750

6.  One Year of Coronavirus Disease 2019 (COVID-19) in Brazil: A Political and Social Overview.

Authors:  Matheus Negri Boschiero; Camila Vantini Capasso Palamim; Manoela Marques Ortega; Renan Marrichi Mauch; Fernando Augusto Lima Marson
Journal:  Ann Glob Health       Date:  2021-05-18       Impact factor: 2.462

7.  Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?

Authors:  Elizabeth Delorme-Axford; Daniel J Klionsky
Journal:  Autophagy       Date:  2020-11-05       Impact factor: 16.016
  7 in total

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