Hideaki Hirashima1, Tomohiro Ono2, Mitsuhiro Nakamura3, Yuki Miyabe4, Nobutaka Mukumoto4, Hiraku Iramina4, Takashi Mizowaki4. 1. Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Japan Society for the Promotion of Science, Japan. 2. Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: tono@kuhp.kyoto-u.ac.jp. 3. Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Division of Medical Physics, Department of Information Technology and Medical Engineering, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 4. Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Abstract
PURPOSE: The purpose of this study was to predict and classify the gamma passing rate (GPR) value by using new features (3D dosiomics features and combined with plan and dosiomics features) together with a machine learning technique for volumetric modulated arc therapy (VMAT) treatment plans. METHODS AND MATERIALS: A total of 888 patients who underwent VMAT were enrolled comprising 1255 treatment plans. Further, 24 plan complexity features and 851 dosiomics features were extracted from the treatment plans. The dataset was randomly split into a training/validation (80%) and test (20%) dataset. The three models for prediction and classification using XGBoost were as follows: (i) plan complexity features-based prediction method (plan model); (ii) 3D dosiomics feature-based prediction model (dosiomics model); (iii) a combination of both the previous models (hybrid model). The prediction performance was evaluated by calculating the mean absolute error (MAE) and the correlation coefficient (CC) between the predicted and measured GPRs. The classification performance was evaluated by calculating the area under curve (AUC) and sensitivity. RESULTS: MAE and CC at γ2%/2 mm in the test dataset were 4.6% and 0.58, 4.3% and 0.61, and 4.2% and 0.63 for the plan model, dosiomics model, and hybrid model, respectively. AUC and sensitivity at γ2%/2 mm in test dataset were 0.73 and 0.70, 0.81 and 0.90, and 0.83 and 0.90 for the plan model, dosiomics model, and hybrid model, respectively. CONCLUSIONS: A combination of both plan and dosiomics features with machine learning technique can improve the prediction and classification performance for GPR.
PURPOSE: The purpose of this study was to predict and classify the gamma passing rate (GPR) value by using new features (3D dosiomics features and combined with plan and dosiomics features) together with a machine learning technique for volumetric modulated arc therapy (VMAT) treatment plans. METHODS AND MATERIALS: A total of 888 patients who underwent VMAT were enrolled comprising 1255 treatment plans. Further, 24 plan complexity features and 851 dosiomics features were extracted from the treatment plans. The dataset was randomly split into a training/validation (80%) and test (20%) dataset. The three models for prediction and classification using XGBoost were as follows: (i) plan complexity features-based prediction method (plan model); (ii) 3D dosiomics feature-based prediction model (dosiomics model); (iii) a combination of both the previous models (hybrid model). The prediction performance was evaluated by calculating the mean absolute error (MAE) and the correlation coefficient (CC) between the predicted and measured GPRs. The classification performance was evaluated by calculating the area under curve (AUC) and sensitivity. RESULTS: MAE and CC at γ2%/2 mm in the test dataset were 4.6% and 0.58, 4.3% and 0.61, and 4.2% and 0.63 for the plan model, dosiomics model, and hybrid model, respectively. AUC and sensitivity at γ2%/2 mm in test dataset were 0.73 and 0.70, 0.81 and 0.90, and 0.83 and 0.90 for the plan model, dosiomics model, and hybrid model, respectively. CONCLUSIONS: A combination of both plan and dosiomics features with machine learning technique can improve the prediction and classification performance for GPR.