William Alexander Cantrell1, Ceylan Colak2, Nancy A Obuchowski3, Kurt P Spindler4, Morgan H Jones5, Naveen Subhas6. 1. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Ave, Cleveland, OH 44195, United States of America. Electronic address: cantrew@ccf.org. 2. Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States of America. Electronic address: colakc@ccf.org. 3. Department of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States of America. Electronic address: obuchon@ccf.org. 4. Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States of America. Electronic address: spindlk@ccf.org. 5. Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States of America. Electronic address: jonesm7@ccf.org. 6. Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States of America. Electronic address: subhasn@ccf.org.
Abstract
BACKGROUND: Knee osteoarthritis (OA) severity is a predictor of outcomes after arthroscopic partial meniscectomy (APM). Magnetic resonance imaging (MRI) grading of OA is predictive of postoperative outcomes; this prospective study assessed whether radiographic grading is also predictive of outcomes. METHODS: Patients who underwent APM between February 2015 and January 2016, underwent radiography and MRI ≤6 months before surgery, and had outcomes from the surgery date and one year later were included. Surgical failure was defined as <10-point improvement in the Knee Osteoarthritis Outcome Score pain subscore. Radiographs were evaluated using Kellgren-Lawrence (KL) grading and continuous and ordinal minimum joint space width (mJSW) measurements; cartilage loss on MRI was evaluated using a modified Outerbridge system. Predictive abilities were estimated using area under the receiver operating characteristic curve (AUC) with 95% confidence intervals (CIs). RESULTS: The study cohort included 66 knees from 64 patients (32 women; mean age, 57.1 years; range, 45-77). Radiographic grading was not predictive of outcomes (KL, AUC = 0.541 [95% CI: 0.358, 0.724]; continuous mJSW, AUC = 0.482 [95% CI: 0.305, 0.659]; ordinal mJSW, AUC = 0.534 [95% CI: 0.433, 0.634]). Comparison of radiographs showing no joint space narrowing (KL grade 0-2) with corresponding MR images demonstrated that 48% of radiographs missed a clinically significant lesion (modified Outerbridge grade ≥ 3). MRI grading was predictive of outcomes (AUC = 0.720 [95% CI: 0.581, 0.859]). CONCLUSIONS: Radiographic grading of OA is not predictive of outcomes after APM; radiographs may miss clinically significant lesions. For outcome prediction, MRI should be used.
BACKGROUND: Knee osteoarthritis (OA) severity is a predictor of outcomes after arthroscopic partial meniscectomy (APM). Magnetic resonance imaging (MRI) grading of OA is predictive of postoperative outcomes; this prospective study assessed whether radiographic grading is also predictive of outcomes. METHODS:Patients who underwent APM between February 2015 and January 2016, underwent radiography and MRI ≤6 months before surgery, and had outcomes from the surgery date and one year later were included. Surgical failure was defined as <10-point improvement in the Knee Osteoarthritis Outcome Score pain subscore. Radiographs were evaluated using Kellgren-Lawrence (KL) grading and continuous and ordinal minimum joint space width (mJSW) measurements; cartilage loss on MRI was evaluated using a modified Outerbridge system. Predictive abilities were estimated using area under the receiver operating characteristic curve (AUC) with 95% confidence intervals (CIs). RESULTS: The study cohort included 66 knees from 64 patients (32 women; mean age, 57.1 years; range, 45-77). Radiographic grading was not predictive of outcomes (KL, AUC = 0.541 [95% CI: 0.358, 0.724]; continuous mJSW, AUC = 0.482 [95% CI: 0.305, 0.659]; ordinal mJSW, AUC = 0.534 [95% CI: 0.433, 0.634]). Comparison of radiographs showing no joint space narrowing (KL grade 0-2) with corresponding MR images demonstrated that 48% of radiographs missed a clinically significant lesion (modified Outerbridge grade ≥ 3). MRI grading was predictive of outcomes (AUC = 0.720 [95% CI: 0.581, 0.859]). CONCLUSIONS: Radiographic grading of OA is not predictive of outcomes after APM; radiographs may miss clinically significant lesions. For outcome prediction, MRI should be used.
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Authors: Mingrui Yang; Ceylan Colak; Kishore K Chundru; Sibaji Gaj; Andreas Nanavati; Morgan H Jones; Carl S Winalski; Naveen Subhas; Xiaojuan Li Journal: Quant Imaging Med Surg Date: 2022-05