Literature DB >> 32705698

Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast: Two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits.

Graham Peet1, F Chris Bennett1, Mariko L Bennett2,3.   

Abstract

Microglia, the brain's tissue-resident macrophages, contribute to the developmental elimination of extranumerary synapses and to pathologic synapse loss in mouse models of neurodegeneration. Two papers published in The EMBO Journal reveal that phosphatidylserine (PS) is a neuronal cue for microglial synapse elimination.
© 2020 The Authors.

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Year:  2020        PMID： 32705698      PMCID： PMC7429477          DOI： 10.15252/embj.2020105924

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  13 in total

Review 1.  Synapse elimination and indelible memory.

Authors:  J W Lichtman; H Colman
Journal:  Neuron       Date:  2000-02       Impact factor: 17.173

Review 2.  Mechanisms of synapse assembly and disassembly.

Authors:  Yukiko Goda; Graeme W Davis
Journal:  Neuron       Date:  2003-10-09       Impact factor: 17.173

3.  GPR56 regulates pial basement membrane integrity and cortical lamination.

Authors:  Shihong Li; Zhaohui Jin; Samir Koirala; Lihong Bu; Lei Xu; Richard O Hynes; Christopher A Walsh; Gabriel Corfas; Xianhua Piao
Journal:  J Neurosci       Date:  2008-05-28       Impact factor: 6.167

4.  The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane.

Authors:  Katsumori Segawa; Sachiko Kurata; Shigekazu Nagata
Journal:  J Biol Chem       Date:  2017-12-24       Impact factor: 5.157

5.  Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast: Two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits.

Authors:  Graham Peet; F Chris Bennett; Mariko L Bennett
Journal:  EMBO J       Date:  2020-07-23       Impact factor: 11.598

6.  A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.

Authors:  Tao Li; Brian Chiou; Casey K Gilman; Rong Luo; Tatsuhiro Koshi; Diankun Yu; Hayeon C Oak; Stefanie Giera; Erin Johnson-Venkatesh; Allie K Muthukumar; Beth Stevens; Hisashi Umemori; Xianhua Piao
Journal:  EMBO J       Date:  2020-05-25       Impact factor: 11.598

7.  Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina.

Authors:  Linda Ruggiero; Mark P Connor; Jeannie Chen; Ralf Langen; Silvia C Finnemann
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-07       Impact factor: 11.205

8.  The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.

Authors:  Stefanie Giera; Yiyu Deng; Rong Luo; Sarah D Ackerman; Amit Mogha; Kelly R Monk; Yanqin Ying; Sung-Jin Jeong; Manabu Makinodan; Allison R Bialas; Bernard S Chang; Beth Stevens; Gabriel Corfas; Xianhua Piao
Journal:  Nat Commun       Date:  2015-01-21       Impact factor: 14.919

Review 9.  Glial Control of Synapse Number in Healthy and Diseased Brain.

Authors:  Eunbeol Lee; Won-Suk Chung
Journal:  Front Cell Neurosci       Date:  2019-02-13       Impact factor: 5.505

10.  Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.

Authors:  Nicole Scott-Hewitt; Fabio Perrucci; Raffaella Morini; Marco Erreni; Matthew Mahoney; Agata Witkowska; Alanna Carey; Elisa Faggiani; Lisa Theresia Schuetz; Sydney Mason; Matteo Tamborini; Matteo Bizzotto; Lorena Passoni; Fabia Filipello; Reinhard Jahn; Beth Stevens; Michela Matteoli
Journal:  EMBO J       Date:  2020-07-13       Impact factor: 11.598
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  3 in total

1.  Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast: Two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits.

Authors:  Graham Peet; F Chris Bennett; Mariko L Bennett
Journal:  EMBO J       Date:  2020-07-23       Impact factor: 11.598

2.  Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques.

Authors:  Ethan R Roy; Gabriel Chiu; Sanming Li; Nicholas E Propson; Rupa Kanchi; Baiping Wang; Cristian Coarfa; Hui Zheng; Wei Cao
Journal:  Immunity       Date:  2022-04-19       Impact factor: 43.474

3.  Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.

Authors:  Tao Li; Diankun Yu; Hayeon C Oak; Beika Zhu; Li Wang; Xueqiao Jiang; Robert S Molday; Arnold Kriegstein; Xianhua Piao
Journal:  EMBO J       Date:  2021-09-29       Impact factor: 11.598
  3 in total

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