Selin Oncul1, Vahid Afshar-Kharghan2. 1. Department of Biochemistry, Faculty of Pharmacy, The University of Hacettepe, Ankara, Turkey. 2. Division of Internal Medicine, Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Abstract
PURPOSE OF REVIEW: To discuss the crosstalk between the complement system and hemostatic factors (coagulation cascade, platelet, endothelium, and Von Willebrand Factor), and the consequences of this interaction under physiologic and pathologic conditions. RECENT FINDINGS: The complement and coagulation systems are comprised of serine proteases and are genetically related. In addition to the common ancestral genes, the complement system and hemostasis interact directly, through protein-protein interactions, and indirectly, on the surface of platelets and endothelial cells. The close interaction between the complement system and hemostatic factors is manifested both in physiologic and pathologic conditions, such as in the inflammatory response to thrombosis, thrombosis at the inflamed area, and thrombotic complications of complement disorders. SUMMARY: The interaction between the complement system and hemostasis is vital for homeostasis and the protective response of the host to tissue injury, but also results in the pathogenesis of several thrombotic and inflammatory disorders.
PURPOSE OF REVIEW: To discuss the crosstalk between the complement system and hemostatic factors (coagulation cascade, platelet, endothelium, and Von Willebrand Factor), and the consequences of this interaction under physiologic and pathologic conditions. RECENT FINDINGS: The complement and coagulation systems are comprised of serine proteases and are genetically related. In addition to the common ancestral genes, the complement system and hemostasis interact directly, through protein-protein interactions, and indirectly, on the surface of platelets and endothelial cells. The close interaction between the complement system and hemostatic factors is manifested both in physiologic and pathologic conditions, such as in the inflammatory response to thrombosis, thrombosis at the inflamed area, and thrombotic complications of complement disorders. SUMMARY: The interaction between the complement system and hemostasis is vital for homeostasis and the protective response of the host to tissue injury, but also results in the pathogenesis of several thrombotic and inflammatory disorders.
Authors: D E Dunn; P Tanawattanacharoen; P Boccuni; S Nagakura; S W Green; M R Kirby; M S Kumar; S Rosenfeld; N S Young Journal: Ann Intern Med Date: 1999-09-21 Impact factor: 25.391
Authors: Jan-Dirk Studt; Johanna A Kremer Hovinga; Gerhard Antoine; Martin Hermann; Manfred Rieger; Friedrich Scheiflinger; Bernhard Lämmle Journal: Blood Date: 2004-09-14 Impact factor: 22.113
Authors: Małgorzata Lewandowska; Monika Englert-Golon; Zbigniew Krasiński; Paweł Piotr Jagodziński; Stefan Sajdak Journal: Int J Environ Res Public Health Date: 2022-06-23 Impact factor: 4.614