Literature DB >> 327016

Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.

E V Genovesi, P A Marx, E F Wheelock.   

Abstract

Friend leukemia virus (FLV) erythroleukemic cells cultured in medium containing FLV-immune serum from dormant FLV-infected mice undergo modulation of FLV cell surface antigens. Modulation was determined by an increased resistance to FLV antibody-mediated complement-dependent lysis and was associated temporally with the capping of FLV-immune complexes at the cell surface. Modulated cells regained their susceptibility to FLV antibody-mediated complement-dependent lysis when transferred to medium containing normal mouse serum. After 48 h of culture in FLV-immune serum, 26% of the FLV erythroleukemic cells were devoid of FLV cell surface antigens as demonstrated by immunofluoresence. Antigenic modulation occurred to a greater extent in cells maintained in logarithmic growth than in cells in GO or resting phase. FLV-antigenic modulation is discussed as a possible mechanism by which antibody induces and maintains FLV-transformed cells in a dormant state.

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Year:  1977        PMID： 327016      PMCID： PMC2180763          DOI： 10.1084/jem.146.2.520

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  39 in total

1.  Impaired macrophage function in Friend virus leukemia: restoration by statolon.

Authors:  M H Levy; E F Wheelock
Journal:  J Immunol       Date:  1975-03       Impact factor: 5.422

2.  Influence of immune stimulators on viral leukemogenesis.

Authors:  P A Marx; E F Wheelock
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

3.  Antibody-induced killing in vivo of L1210/MTX-R cells quantitated in passively immunized mice with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity.

Authors:  G A Carlson; G Terres
Journal:  J Immunol       Date:  1976-09       Impact factor: 5.422

4.  Suppression of extablished Friend virus leukemia by statolon: potentiation of statolon's leukemosuppressive activity by chlorite-oxidized oxyamylose.

Authors:  O S Weislow; E F Wheelock
Journal:  Infect Immun       Date:  1975-01       Impact factor: 3.441

Review 5.  Surface modulation in cell recognition and cell growth.

Authors:  G M Edelman
Journal:  Science       Date:  1976-04-16       Impact factor: 47.728

6.  Suppression of murine type-C RNA virogenes by type-specific oncornavirus vaccines: prospects for prevention of cancer.

Authors:  R J Huebner; R V Gilden; W T Lane; R Toni; R W Trimmer; P R Hill
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

7.  Different mechanisms for the modulation of TL antigens on murine lymphoid cells.

Authors:  N L Esmon; J R Little
Journal:  J Immunol       Date:  1976-09       Impact factor: 5.422

8.  Antibody-induced modulation and shedding of mammary tumor virus antigens on the surfaces of GR ascites leukemia cells as compared with normal antigens.

Authors:  J Calafat; J Hilgers; W J Van Bitterswijk; M Verbeet; P C Hageman
Journal:  J Natl Cancer Inst       Date:  1976-05       Impact factor: 13.506

9.  Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes.

Authors:  R J Huebner; R V Gilden; R Toni; R W Hill; R W Trimmer; D C Fish; B Sass
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

10.  Relationship of Friend murine leukemia virus production to growth and hemoglobin synthesis in cultured erythroleukemia cells.

Authors:  C C Sherton; L H Evans; E Polonoff; D Kabat
Journal:  J Virol       Date:  1976-07       Impact factor: 5.103
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  9 in total

1.  Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.

Authors:  B Chesebro; K Wehrly; D Doig; J Nishio
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

2.  Membrane-bound antibodies to bloodstream Trypanosoma cruzi in mice: strain differences in susceptibility to complement-mediated lysis.

Authors:  A U Krettli; P Weisz-Carrington; R S Nussenzweig
Journal:  Clin Exp Immunol       Date:  1979-09       Impact factor: 4.330

3.  Persistence of infectious Friend virus in spleens of mice after spontaneous recovery from virus-induced erythroleukemia.

Authors:  B Chesebro; M Bloom; K Wehrly; J Nishio
Journal:  J Virol       Date:  1979-12       Impact factor: 5.103

4.  Establishment and control of the L5178Y-cell tumor dormant state in DBA/2 mice.

Authors:  E F Wheelock; M K Robinson; G A Truitt
Journal:  Cancer Metastasis Rev       Date:  1982       Impact factor: 9.264

5.  In vitro modulation of viral cell surface glycoproteins by anti-viral antibody in the presence of complement.

Authors:  N T Gorman; P J Lachmann
Journal:  Clin Exp Immunol       Date:  1982-12       Impact factor: 4.330

6.  Antibody-induced loss of Friend virus leukemia cell surface antigens occurs during progression of erythroleukemia in F1 mice.

Authors:  D Doig; B Chesebro
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

7.  Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.

Authors:  D Doig; B Chesebro
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307

8.  Persistence and pathogenicity of defective Friend spleen focus-forming virus. Decreased transplantability of hemopoietic cells as a marker for preleukemic change.

Authors:  R J Eckner; K L Hettrick
Journal:  J Exp Med       Date:  1979-02-01       Impact factor: 14.307

Review 9.  Antibody-mediated destruction of virus-infected cells.

Authors:  J G Sissons; M B Oldstone
Journal:  Adv Immunol       Date:  1980       Impact factor: 3.543
  9 in total

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