Jitender Sareen1,2,3, Kendiss Olafson4, Maia S Kredentser5, O Joseph Bienvenu6, Marcus Blouw4, James M Bolton1,2,3, Sarvesh Logsetty1,7, Dan Chateau1,2,8, Yao Nie8, Charles N Bernstein4, Tracie O Afifi1,2, Murray B Stein9,10, William D Leslie4, Laurence Y Katz1, Natalie Mota1,5, Renée El-Gabalawy1,3,5,11, Sophia Sweatman12, Ruth Ann Marrie2,4. 1. Department of Psychiatry, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 2. Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 3. Department of Psychology, University of Manitoba, Winnipeg, MB, Canada. 4. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 5. Department of Clinical Health Psychology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 6. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD. 7. Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 8. Manitoba Centre for Health Policy, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 9. Department of Psychiatry, University of California San Diego, La Jolla, CA. 10. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA. 11. Department of Anesthesiology, Perioperative and Pain Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. 12. Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Abstract
OBJECTIVE: To estimate incidence of newly diagnosed mental disorders among ICU patients. DESIGN: Retrospective-matched cohort study using a population-based administrative database. SETTING: Manitoba, Canada. PARTICIPANTS: A total of 49,439 ICU patients admitted between 2000 and 2012 were compared with two control groups (hospitalized: n = 146,968 and general population: n = 141,937), matched on age (± 2 yr), sex, region of residence, and hospitalization year. INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: Incident mental disorders (mood, anxiety, substance use, personality, posttraumatic stress disorder, schizophrenia, and psychotic disorders) not diagnosed during the 5-year period before the index ICU or hospital admission date (including matched general population group), but diagnosed during the subsequent 5-year period. Multivariable survival models adjusted for sociodemographic variables, Charlson comorbidity index, admission diagnostic category, and number of ICU and non-ICU exposures. ICU cohort had a 14.5% (95% CI, 14.0-15.0) and 42.7% (95% CI, 42.0-43.5) age- and sex-standardized incidence of any diagnosed mental disorder at 1 and 5 years post-ICU exposure, respectively. In multivariable analysis, ICU cohort had increased risk of any diagnosed mental disorder at all time points versus the hospitalized cohort (year 5: adjusted hazard ratio, 2.00; 95% CI, 1.80-2.23) and the general population cohort (year 5: adjusted hazard ratio, 3.52; 95% CI, 3.23-3.83). A newly diagnosed mental disorder was associated with younger age, female sex, more recent admitting years, presence of preexisting comorbidities, and repeat ICU admission. CONCLUSIONS: ICU admission is associated with an increased incidence of mood, anxiety, substance use, and personality disorders over a 5-year period.
OBJECTIVE: To estimate incidence of newly diagnosed mental disorders among ICU patients. DESIGN: Retrospective-matched cohort study using a population-based administrative database. SETTING: Manitoba, Canada. PARTICIPANTS: A total of 49,439 ICU patients admitted between 2000 and 2012 were compared with two control groups (hospitalized: n = 146,968 and general population: n = 141,937), matched on age (± 2 yr), sex, region of residence, and hospitalization year. INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: Incident mental disorders (mood, anxiety, substance use, personality, posttraumatic stress disorder, schizophrenia, and psychotic disorders) not diagnosed during the 5-year period before the index ICU or hospital admission date (including matched general population group), but diagnosed during the subsequent 5-year period. Multivariable survival models adjusted for sociodemographic variables, Charlson comorbidity index, admission diagnostic category, and number of ICU and non-ICU exposures. ICU cohort had a 14.5% (95% CI, 14.0-15.0) and 42.7% (95% CI, 42.0-43.5) age- and sex-standardized incidence of any diagnosed mental disorder at 1 and 5 years post-ICU exposure, respectively. In multivariable analysis, ICU cohort had increased risk of any diagnosed mental disorder at all time points versus the hospitalized cohort (year 5: adjusted hazard ratio, 2.00; 95% CI, 1.80-2.23) and the general population cohort (year 5: adjusted hazard ratio, 3.52; 95% CI, 3.23-3.83). A newly diagnosed mental disorder was associated with younger age, female sex, more recent admitting years, presence of preexisting comorbidities, and repeat ICU admission. CONCLUSIONS: ICU admission is associated with an increased incidence of mood, anxiety, substance use, and personality disorders over a 5-year period.
Authors: Lioudmila V Karnatovskaia; Jason M Schultz; Alexander S Niven; Amanda J Steele; Brittany A Baker; Kemuel L Philbrick; Kathryn T Del Valle; Kimberly R Johnson; Ognjen Gajic; Katalin Varga Journal: Crit Care Explor Date: 2021-04-26
Authors: Shannon M Fernando; Danial Qureshi; Manish M Sood; Michael Pugliese; Robert Talarico; Daniel T Myran; Margaret S Herridge; Dale M Needham; Bram Rochwerg; Deborah J Cook; Hannah Wunsch; Robert A Fowler; Damon C Scales; O Joseph Bienvenu; Kathryn M Rowan; Magdalena Kisilewicz; Laura H Thompson; Peter Tanuseputro; Kwadwo Kyeremanteng Journal: BMJ Date: 2021-05-05
Authors: Lioudmila V Karnatovskaia; Katalin Varga; Alexander S Niven; Phillip J Schulte; Midhat Mujic; Ognjen Gajic; Brent A Bauer; Matthew M Clark; Roberto P Benzo; Kemuel L Philbrick Journal: Crit Care Date: 2021-12-20 Impact factor: 19.334