Literature DB >> 32693739

They are likely to be there: using a family-centered index testing approach to identify children living with HIV in Kenya.

Nicollate Okoko1, Jayne L Kulzer2, Kristen Ohe3, Margaret Mburu4, Hellen Muttai5, Lisa L Abuogi6, Elizabeth A Bukusi1, Craig R Cohen2, Jeremy Penner7.   

Abstract

In Kenya, only half of children with a parent living with HIV have been tested for HIV. The effectiveness of family-centered index testing to identify children (0-14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care between May and July 2015; family testing, results, and linkage to treatment outcomes were followed through May 2016 at 60 high-volume clinics in Kenya. Chi square test compared yield (percentage of HIV tests positive) among children tested through family-centered index testing, outpatient and inpatient testing. Review of 1937 index client charts led to 3005 eligible children identified for testing. Of 2848 (94.8%) children tested through family-centered index testing, 127 (4.5%) had HIV diagnosed, 100 (78.7%) were linked to care, and 85 of those eligible (91.4%) initiated antiretroviral therapy (ART).Family testing resulted in higher yield compared to inpatient (1.8%, p < 0.001) or outpatient testing (1.6%, p < 0.001). The absolute number of children living with HIV identified was highest with outpatient testing. The relative contribution of testing approach to total children identified with HIV was outpatient testing (69%), family testing (26%), and inpatient testing (5%). The family testing approach demonstrated promise in achieving the first two "90s" (identification and ART initiation) of the 90-90-90 targets for children, with additional effort required to improve linkage from testing to treatment.

Entities:  

Keywords:  Africa; HIV; diagnosis; screening; treatment

Mesh:

Substances:

Year:  2020        PMID: 32693739      PMCID: PMC7530071          DOI: 10.1177/0956462420926344

Source DB:  PubMed          Journal:  Int J STD AIDS        ISSN: 0956-4624            Impact factor:   1.359


  24 in total

1.  HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment.

Authors:  Katherine Luzuriaga; Barbara Tabak; Manuel Garber; Ya Hui Chen; Carrie Ziemniak; Margaret M McManus; Danielle Murray; Matthew C Strain; Douglas D Richman; Tae-Wook Chun; Coleen K Cunningham; Deborah Persaud
Journal:  J Infect Dis       Date:  2014-05-21       Impact factor: 5.226

2.  Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy.

Authors:  Edwin D Charlebois; Theodore D Ruel; Anne F Gasasira; Jane Achan; Frederick Kateera; Caroline Akello; Huyen Cao; Grant Dorsey; Philip J Rosenthal; Isaac Ssewanyana; Moses R Kamya; Diane V Havlir
Journal:  J Acquir Immune Defic Syndr       Date:  2010-11       Impact factor: 3.731

3.  "They have already thrown away their chicken": barriers affecting participation by HIV-infected women in care and treatment programs for their infants in Blantyre, Malawi.

Authors:  Marie Collins Donahue; Queen Dube; Anna Dow; Eric Umar; Annelies Van Rie
Journal:  AIDS Care       Date:  2012-02-21

4.  Routine inpatient human immunodeficiency virus testing system increases access to pediatric human immunodeficiency virus care in sub-Saharan Africa.

Authors:  Eric D McCollum; Geoffrey A Preidis; Carrie L Golitko; Linias D Siwande; Charles Mwansambo; Peter N Kazembe; Irving Hoffman; Mina C Hosseinipour; Gordon E Schutze; Mark W Kline
Journal:  Pediatr Infect Dis J       Date:  2011-05       Impact factor: 2.129

5.  Acceptance of HIV testing for children ages 18 months to 13 years identified through voluntary, home-based HIV counseling and testing in western Kenya.

Authors:  Rachel C Vreeman; Winstone M Nyandiko; Paula Braitstein; Martin C Were; Samwel O Ayaya; Samson K Ndege; Sarah E Wiehe
Journal:  J Acquir Immune Defic Syndr       Date:  2010-10       Impact factor: 3.731

6.  HIV testing coverage of family members of adult antiretroviral therapy patients in Malawi.

Authors:  D Cohen; M Lungu; J J van Oosterhout
Journal:  AIDS Care       Date:  2010-11

Review 7.  HIV testing for children in resource-limited settings: what are we waiting for?

Authors:  Scott Kellerman; Shaffiq Essajee
Journal:  PLoS Med       Date:  2010-07-20       Impact factor: 11.069

8.  Initiation of antiretroviral therapy before 6 months of age is associated with faster growth recovery in South African children perinatally infected with human immunodeficiency virus.

Authors:  Stephanie Shiau; Stephen Arpadi; Renate Strehlau; Leigh Martens; Faeezah Patel; Ashraf Coovadia; Elaine J Abrams; Louise Kuhn
Journal:  J Pediatr       Date:  2013-01-11       Impact factor: 4.406

Review 9.  Beyond early infant diagnosis: case finding strategies for identification of HIV-infected infants and children.

Authors:  Saeed Ahmed; Maria H Kim; Nandita Sugandhi; B Ryan Phelps; Rachael Sabelli; Mamadou O Diallo; Paul Young; Dana Duncan; Scott E Kellerman
Journal:  AIDS       Date:  2013-11       Impact factor: 4.177

10.  Evaluation and Utility of a Family Information Table to Identify and Test Children at Risk for HIV in Kenya.

Authors:  Michelle Meyer; Molly Elmer-DeWitt; Cinthia Blat; Starley B Shade; Ijaa Kapule; Elizabeth Bukusi; Craig R Cohen; Lisa Abuogi
Journal:  Int J MCH AIDS       Date:  2014
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  1 in total

1.  Home-based HIV Testing for Children: A Useful Complement for Caregivers with More Children, Who are Male, and with an HIV Negative Partner.

Authors:  Jiayu Wang; Cyrus Mugo; Vincent O Omondi; Irene N Njuguna; Elizabeth Maleche-Obimbo; Irene Inwani; James P Hughes; Jennifer A Slyker; Grace John-Stewart; Dalton Wamalwa; Anjuli D Wagner
Journal:  AIDS Behav       Date:  2022-03-19
  1 in total

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