Tamer Yazar1, Hülya Olgun Yazar2, Ali Aygün3, Volkan Karabacak4, Yavuz Altunkaynak5, Dursun Kirbaş6. 1. Neurology, Zeytinburnu Surp Pirgıç Armenian Hospital, Zakirbaşı Sokak No:32, 34020, Kazlıçeşme, İstanbul, Turkey. tamer.yazar@yahoo.com.tr. 2. Ordu University Education and Research Hospital, Ordu, Turkey. 3. Faculty of Medicine, Department of Emergency Medicine, Ordu University, Ordu, Turkey. 4. Health Department of Public Health, Ordu, Turkey. 5. Dr. Mazhar Osman Psychiatric and Neurological Diseases Education and Research Hospital, İstanbul, Turkey. 6. T.C. İstanbul Yeni Yüzyıl Universitesi, İstanbul, Turkey.
Abstract
OBJECTIVE: In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine). METHOD: The study included 300 migraine patients and 150 healthy controls for a total of 450 individuals. Migraine and subtypes were diagnosed according to International Classification of Headache Disorders-2013 criteria. Patients were evaluated during attendance at the neurology clinic. RESULTS: Our patient group was 77.0% female and disease duration was 9.2 ± 7.2 years. Our control group comprised 77.3% females. The age intervals in the patient and control groups were 36.4 ± 10.4 years and 36.0 ± 8.1 years. There was no statistically significant difference between our control and patient groups in terms of age and gender (p = .937 and p = .655). The serum UA, ferritin, and urea levels in our patient group were found to be significantly low compared to the healthy control group (p < .001). The serum UA levels in the migraine and control groups were 3.7 ± 0.7 and 4.6 ± 0.7 mg/dL, respectively (p < .001). There were no statistically significant differences observed between serum uric acid levels and other blood parameters between aura/without aura and episodic/chronic migraine subtypes (p > .05). CONCLUSION: Our study supports the hypothesis that the oxidative stress marker of serum uric acid levels may be associated with migraine diagnosis, concluding that serum uric acid levels were not significant for migraine subtypes.
OBJECTIVE: In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine). METHOD: The study included 300 migrainepatients and 150 healthy controls for a total of 450 individuals. Migraine and subtypes were diagnosed according to International Classification of Headache Disorders-2013 criteria. Patients were evaluated during attendance at the neurology clinic. RESULTS: Our patient group was 77.0% female and disease duration was 9.2 ± 7.2 years. Our control group comprised 77.3% females. The age intervals in the patient and control groups were 36.4 ± 10.4 years and 36.0 ± 8.1 years. There was no statistically significant difference between our control and patient groups in terms of age and gender (p = .937 and p = .655). The serum UA, ferritin, and urea levels in our patient group were found to be significantly low compared to the healthy control group (p < .001). The serum UA levels in the migraine and control groups were 3.7 ± 0.7 and 4.6 ± 0.7 mg/dL, respectively (p < .001). There were no statistically significant differences observed between serum uric acid levels and other blood parameters between aura/without aura and episodic/chronic migraine subtypes (p > .05). CONCLUSION: Our study supports the hypothesis that the oxidative stress marker of serum uric acid levels may be associated with migraine diagnosis, concluding that serum uric acid levels were not significant for migraine subtypes.
Entities:
Keywords:
Chronic migraine; Episodic migraine; Migraine; Migraine with aura; Migraine without aura; Oxidative stress; Uric acid
Authors: Biman K Ray; Neelanjana Paul; Avijit Hazra; Sujata Das; Malay K Ghosal; Amar K Misra; Tapas K Banerjee; Arijit Chaudhuri; Shyamal K Das Journal: Neurol India Date: 2017 Nov-Dec Impact factor: 2.117
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