Niloofar Yousefi Moteghaed1, Ahmad Mostaar1,2, Keivan Maghooli3, Mohammad Houshyari4, Ahmad Ameri5. 1. Department of Biomedical Engineering and Medical Physics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran. 3. Department of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran. 4. Department of Radiation Oncology, Shohada-e-Tajrish Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Department of Radiation Oncology, Imam Hossein Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
AIM: The aim of this study is to construct and evaluate Pseudo-CT images (P-CTs) for electron density calculation to facilitate external radiotherapy treatment planning. BACKGROUND: Despite numerous benefits, computed tomography (CT) scan does not provide accurate information on soft tissue contrast, which often makes it difficult to precisely differentiate target tissues from the organs at risk and determine the tumor volume. Therefore, MRI imaging can reduce the variability of results when registering with a CT scan. MATERIALS AND METHODS: In this research, a fuzzy clustering algorithm was used to segment images into different tissues, also linear regression methods were used to design the regression model based on the feature extraction method and the brightness intensity values. The results of the proposed algorithm for dose-volume histogram (DVH), Isodose curves, and gamma analysis were investigated using the RayPlan treatment planning system, and VeriSoft software. Furthermore, various statistical indices such as Mean Absolute Error (MAE), Mean Error (ME), and Structural Similarity Index (SSIM) were calculated. RESULTS: The MAE of a range of 45-55 was found from the proposed methods. The relative difference error between the PTV region of the CT and the Pseudo-CT was 0.5, and the best gamma rate was 95.4% based on the polar coordinate feature and proposed polynomial regression model. CONCLUSION: The proposed method could support the generation of P-CT data for different parts of the brain region from a collection of MRI series with an acceptable average error rate by different evaluation criteria.
AIM: The aim of this study is to construct and evaluate Pseudo-CT images (P-CTs) for electron density calculation to facilitate external radiotherapy treatment planning. BACKGROUND: Despite numerous benefits, computed tomography (CT) scan does not provide accurate information on soft tissue contrast, which often makes it difficult to precisely differentiate target tissues from the organs at risk and determine the tumor volume. Therefore, MRI imaging can reduce the variability of results when registering with a CT scan. MATERIALS AND METHODS: In this research, a fuzzy clustering algorithm was used to segment images into different tissues, also linear regression methods were used to design the regression model based on the feature extraction method and the brightness intensity values. The results of the proposed algorithm for dose-volume histogram (DVH), Isodose curves, and gamma analysis were investigated using the RayPlan treatment planning system, and VeriSoft software. Furthermore, various statistical indices such as Mean Absolute Error (MAE), Mean Error (ME), and Structural Similarity Index (SSIM) were calculated. RESULTS: The MAE of a range of 45-55 was found from the proposed methods. The relative difference error between the PTV region of the CT and the Pseudo-CT was 0.5, and the best gamma rate was 95.4% based on the polar coordinate feature and proposed polynomial regression model. CONCLUSION: The proposed method could support the generation of P-CT data for different parts of the brain region from a collection of MRI series with an acceptable average error rate by different evaluation criteria.
Authors: Stan J Hoogcarspel; Joanne M Van der Velden; Jan J W Lagendijk; Marco van Vulpen; Bas W Raaymakers Journal: Phys Med Biol Date: 2014-11-11 Impact factor: 3.609
Authors: Jason A Dowling; Jidi Sun; Peter Pichler; David Rivest-Hénault; Soumya Ghose; Haylea Richardson; Chris Wratten; Jarad Martin; Jameen Arm; Leah Best; Shekhar S Chandra; Jurgen Fripp; Frederick W Menk; Peter B Greer Journal: Int J Radiat Oncol Biol Phys Date: 2015-09-05 Impact factor: 7.038