Reilly D Hobbs1, Elizabeth L Norton2, Xiaoting Wu1, Cristen J Willer3, Scott L Hummell4, Richard L Prager1, Jonathan Afilalo5, Whitney E Hornsby6, Bo Yang7. 1. University of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich. 2. Creighton University School of Medicine, Omaha, Neb. 3. University of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Internal Medicine, Michigan Medicine, Ann Arbor, Mich; Department of Biostatistics, University of Michigan, School of Public Health, Ann Arbor, Mich; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Mich. 4. University of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Internal Medicine, Michigan Medicine, Ann Arbor, Mich. 5. McGill University - Jewish General Hospital, Montreal, Quebec, Canada; Division of Cardiology and Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, Quebec, Canada. 6. University of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Internal Medicine, Michigan Medicine, Ann Arbor, Mich. Electronic address: whornsby@med.umich.edu. 7. University of Michigan, Michigan Medicine, Ann Arbor, Mich; Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich. Electronic address: boya@med.umich.edu.
Abstract
OBJECTIVE: The study objective was to evaluate whether 5-m gait speed, an established marker of frailty, is associated with postoperative events after elective proximal aortic surgery. METHODS: We performed a retrospective review of 435 patients aged more than 60 years who underwent elective proximal aortic surgery, defined as surgery on the aortic root, ascending aorta, or aortic arch through median sternotomy. Patients completed a 5-m gait speed test within 30 days before surgery. We evaluated the association between categoric (slow, ≤0.83 m/s and normal, >0.83 m/s) and continuous gait speed and the likelihood of experiencing the composite outcome before and after adjustment for European System for Cardiac Operative Risk Evaluation II. The composite outcome included in-hospital mortality, renal failure, prolonged ventilation, and discharge location. Secondary outcomes were 1-year mortality and 5-year survival. RESULTS: Of the study population, 30.3% (132/435) were categorized as slow. Slow walkers were significantly more likely to have in-hospital mortality, prolonged ventilation, and renal failure, and were less likely to be discharged home (all P < .05). The composite outcome was 2 times more likely to occur for slow walkers (gait speed categoric adjusted odds ratio, 2.08; 95% confidence interval, 1.27-3.40; P = .004). Moreover, a unit (1 m/s) increase in gait speed (continuous) was associated with 73% lower risk of experiencing the composite outcome (odds ratio, 0.27; 95% confidence interval, 0.11-0.68; P = .006). CONCLUSIONS: Slow gait speed is a preoperative indicator of risk for postoperative events after elective proximal aortic surgery. Gait speed may be an important tool to complement existing operative risk models, and its application may identify patients who may benefit from presurgical and postsurgical rehabilitation.
OBJECTIVE: The study objective was to evaluate whether 5-m gait speed, an established marker of frailty, is associated with postoperative events after elective proximal aortic surgery. METHODS: We performed a retrospective review of 435 patients aged more than 60 years who underwent elective proximal aortic surgery, defined as surgery on the aortic root, ascending aorta, or aortic arch through median sternotomy. Patients completed a 5-m gait speed test within 30 days before surgery. We evaluated the association between categoric (slow, ≤0.83 m/s and normal, >0.83 m/s) and continuous gait speed and the likelihood of experiencing the composite outcome before and after adjustment for European System for Cardiac Operative Risk Evaluation II. The composite outcome included in-hospital mortality, renal failure, prolonged ventilation, and discharge location. Secondary outcomes were 1-year mortality and 5-year survival. RESULTS: Of the study population, 30.3% (132/435) were categorized as slow. Slow walkers were significantly more likely to have in-hospital mortality, prolonged ventilation, and renal failure, and were less likely to be discharged home (all P < .05). The composite outcome was 2 times more likely to occur for slow walkers (gait speed categoric adjusted odds ratio, 2.08; 95% confidence interval, 1.27-3.40; P = .004). Moreover, a unit (1 m/s) increase in gait speed (continuous) was associated with 73% lower risk of experiencing the composite outcome (odds ratio, 0.27; 95% confidence interval, 0.11-0.68; P = .006). CONCLUSIONS: Slow gait speed is a preoperative indicator of risk for postoperative events after elective proximal aortic surgery. Gait speed may be an important tool to complement existing operative risk models, and its application may identify patients who may benefit from presurgical and postsurgical rehabilitation.
Authors: Loren F Hiratzka; George L Bakris; Joshua A Beckman; Robert M Bersin; Vincent F Carr; Donald E Casey; Kim A Eagle; Luke K Hermann; Eric M Isselbacher; Ella A Kazerooni; Nicholas T Kouchoukos; Bruce W Lytle; Dianna M Milewicz; David L Reich; Souvik Sen; Julie A Shinn; Lars G Svensson; David M Williams Journal: Circulation Date: 2010-03-16 Impact factor: 29.690
Authors: Jonathan Afilalo; Sunghee Kim; Sean O'Brien; J Matthew Brennan; Fred H Edwards; Michael J Mack; James B McClurken; Joseph C Cleveland; Peter K Smith; David M Shahian; Karen P Alexander Journal: JAMA Cardiol Date: 2016-06-01 Impact factor: 14.676
Authors: Bo Yang; Himanshu J Patel; Elizabeth L Norton; Christina Debenedictus; Linda Farhat; Xiaoting Wu; Kevin He; Whitney E Hornsby; Donald S Likosky; G Michael Deeb Journal: Ann Thorac Surg Date: 2018-04-03 Impact factor: 4.330
Authors: Jonathan Afilalo; Mark J Eisenberg; Jean-François Morin; Howard Bergman; Johanne Monette; Nicolas Noiseux; Louis P Perrault; Karen P Alexander; Yves Langlois; Nandini Dendukuri; Patrick Chamoun; Georges Kasparian; Sophie Robichaud; S Michael Gharacholou; Jean-François Boivin Journal: J Am Coll Cardiol Date: 2010-11-09 Impact factor: 24.094
Authors: Joakim Alfredsson; Amanda Stebbins; J Matthew Brennan; Roland Matsouaka; Jonathan Afilalo; Eric D Peterson; Sreekanth Vemulapalli; John S Rumsfeld; David Shahian; Michael J Mack; Karen P Alexander Journal: Circulation Date: 2016-02-26 Impact factor: 29.690
Authors: Michael J Englesbe; Dane R Grenda; June A Sullivan; Brian A Derstine; Brooke N Kenney; Kyle H Sheetz; William C Palazzolo; Nicholas C Wang; Rebecca L Goulson; Jay S Lee; Stewart C Wang Journal: Surgery Date: 2017-02-04 Impact factor: 3.982
Authors: L K Bickerstaff; P C Pairolero; L H Hollier; L J Melton; H J Van Peenen; K J Cherry; J W Joyce; J T Lie Journal: Surgery Date: 1982-12 Impact factor: 3.982
Authors: Jonathan Afilalo; Abhinav Sharma; Shuaiqi Zhang; J Matthew Brennan; Fred H Edwards; Michael J Mack; James B McClurken; Joseph C Cleveland; Peter K Smith; David M Shahian; Eric D Peterson; Karen P Alexander Journal: J Am Heart Assoc Date: 2018-12-04 Impact factor: 5.501
Authors: Motoaki Takamura; Toshimasa Sone; Takayuki Kawamura; Reiko Suzuki; Nobuaki Moriyama; Seiji Yasumura Journal: Int J Environ Res Public Health Date: 2021-11-24 Impact factor: 3.390