Nina L Schrager1, Amelia K Wesselink2, Tanran R Wang2, Elizabeth E Hatch2, Kenneth J Rothman3, Ellen M Mikkelsen4, Renée D Boynton-Jarrett5, Lauren A Wise2. 1. Department of Epidemiology, Boston University School of Public Health, Boston, MA. Electronic address: nina15@bu.edu. 2. Department of Epidemiology, Boston University School of Public Health, Boston, MA. 3. Department of Epidemiology, Boston University School of Public Health, Boston, MA; RTI Health Solutions, Research Triangle Park, NC. 4. Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark. 5. Department of Pediatrics, Boston University School of Medicine, Boston, MA.
Abstract
PURPOSE: The purpose of this study is to evaluate socioeconomic determinants of fecundability. METHODS: Among 8654 female pregnancy planners from Pregnancy Study Online, a North American prospective cohort study (2013-2019), we examined associations between socioeconomic status and fecundability (the per-cycle probability of conception). Information on income and education was collected via baseline questionnaires. Bimonthly follow-up questionnaires were used to ascertain pregnancy status. We estimated fecundability ratios (FRs) and 95% confidence intervals (CIs) using proportional probabilities regression, controlling for potential confounders. RESULTS: Relative to an annual household income of greater than or equal to $150,000, adjusted FRs were 0.91 (95% CI: 0.83-1.01) for less than $50,000, 0.99 (95% CI: 0.92-1.07) for $50,000-$99,000, and 1.09 (95% CI: 1.01-1.18) for $100,000-$149,000. FRs for less than 12, 13-15, and 16 years of education, relative to greater than or equal to 17 years, were 0.90 (95% CI: 0.76-1.08), 0.84 (95% CI: 0.78-0.91), and 0.89 (95% CI: 0.84-0.95), respectively. Slightly stronger associations for income and education were seen among older women. CONCLUSIONS: Lower levels of education and income were associated with modestly reduced fecundability. These results demonstrate the presence of socioeconomic disparities in fecundability.
PURPOSE: The purpose of this study is to evaluate socioeconomic determinants of fecundability. METHODS: Among 8654 female pregnancy planners from Pregnancy Study Online, a North American prospective cohort study (2013-2019), we examined associations between socioeconomic status and fecundability (the per-cycle probability of conception). Information on income and education was collected via baseline questionnaires. Bimonthly follow-up questionnaires were used to ascertain pregnancy status. We estimated fecundability ratios (FRs) and 95% confidence intervals (CIs) using proportional probabilities regression, controlling for potential confounders. RESULTS: Relative to an annual household income of greater than or equal to $150,000, adjusted FRs were 0.91 (95% CI: 0.83-1.01) for less than $50,000, 0.99 (95% CI: 0.92-1.07) for $50,000-$99,000, and 1.09 (95% CI: 1.01-1.18) for $100,000-$149,000. FRs for less than 12, 13-15, and 16 years of education, relative to greater than or equal to 17 years, were 0.90 (95% CI: 0.76-1.08), 0.84 (95% CI: 0.78-0.91), and 0.89 (95% CI: 0.84-0.95), respectively. Slightly stronger associations for income and education were seen among older women. CONCLUSIONS: Lower levels of education and income were associated with modestly reduced fecundability. These results demonstrate the presence of socioeconomic disparities in fecundability.
Authors: Elizabeth E Hatch; Kristen A Hahn; Lauren A Wise; Ellen M Mikkelsen; Ramya Kumar; Matthew P Fox; Daniel R Brooks; Anders H Riis; Henrik Toft Sorensen; Kenneth J Rothman Journal: Epidemiology Date: 2016-01 Impact factor: 4.822
Authors: Lauren A Wise; Kenneth J Rothman; Ellen M Mikkelsen; Joseph B Stanford; Amelia K Wesselink; Craig McKinnon; Siobhan M Gruschow; Casie E Horgan; Aleta S Wiley; Kristen A Hahn; Henrik Toft Sørensen; Elizabeth E Hatch Journal: Paediatr Perinat Epidemiol Date: 2015-07 Impact factor: 3.980
Authors: Melissa F Wellons; Cora E Lewis; Stephen M Schwartz; Erica P Gunderson; Pamela J Schreiner; Barbara Sternfeld; Josh Richman; Cynthia K Sites; David S Siscovick Journal: Fertil Steril Date: 2008-03-05 Impact factor: 7.329
Authors: Mary D Willis; Olivia R Orta; Collette Ncube; Amelia K Wesselink; Lan N Ðoàn; Kipruto Kirwa; Renée Boynton-Jarrett; Elizabeth E Hatch; Lauren A Wise Journal: JAMA Netw Open Date: 2022-06-01