Literature DB >> 32680971

Small molecule AX-024 targets T cell receptor signaling by disrupting CD3ε-Nck interaction.

Balbino Alarcon1, Aldo Borroto2.   

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Year:  2020        PMID： 32680971      PMCID： PMC7380186          DOI： 10.1074/jbc.L120.014338

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


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  4 in total

Review 1.  ZAP-70: an essential kinase in T-cell signaling.

Authors:  Haopeng Wang; Theresa A Kadlecek; Byron B Au-Yeung; Hanna E Sjölin Goodfellow; Lih-Yun Hsu; Tanya S Freedman; Arthur Weiss
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-05       Impact factor: 10.005

2.  First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.

Authors:  Aldo Borroto; Diana Reyes-Garau; M Angeles Jiménez; Esther Carrasco; Beatriz Moreno; Sara Martínez-Pasamar; José R Cortés; Almudena Perona; David Abia; Soledad Blanco; Manuel Fuentes; Irene Arellano; Juan Lobo; Haleh Heidarieh; Javier Rueda; Pilar Esteve; Danay Cibrián; Ana Martinez-Riaño; Pilar Mendoza; Cristina Prieto; Enrique Calleja; Clara L Oeste; Alberto Orfao; Manuel Fresno; Francisco Sánchez-Madrid; Antonio Alcamí; Paola Bovolenta; Pilar Martín; Pablo Villoslada; Antonio Morreale; Angel Messeguer; Balbino Alarcon
Journal:  Sci Transl Med       Date:  2016-12-21       Impact factor: 17.956

3.  Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.

Authors:  Kirsten Richter; Arne C Rufer; Magali Muller; Dominique Burger; Fabio Casagrande; Tabea Grossenbacher; Sylwia Huber; Melanie N Hug; Philipp Koldewey; Andrea D'Osualdo; Daniel Schlatter; Theodor Stoll; Markus G Rudolph
Journal:  J Biol Chem       Date:  2020-04-21       Impact factor: 5.157

4.  Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor.

Authors:  Claudia Juraske; Piyamaporn Wipa; Anna Morath; Jose Villacorta Hidalgo; Frederike A Hartl; Katrin Raute; Hans-Heinrich Oberg; Daniela Wesch; Paul Fisch; Susana Minguet; Sutatip Pongcharoen; Wolfgang W Schamel
Journal:  Front Immunol       Date:  2018-07-09       Impact factor: 7.561
  4 in total
  2 in total

1.  Reply to Alarcon and Borroto: Small molecule AX-024 reduces T cell proliferation independently of CD3ε-Nck1 interaction at SH3.1.

Authors:  Kirsten Richter; Arne C Rufer; Magali Muller; Dominique Burger; Fabio Casagrande; Tabea Grossenbacher; Sylwia Huber; Melanie N Hug; Philipp Koldewey; Andrea D'Osualdo; Daniel Schlatter; Theodor Stoll; Markus G Rudolph
Journal:  J Biol Chem       Date:  2020-07-17       Impact factor: 5.157

2.  Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells.

Authors:  Aussanee Nuiyen; Araya Rattanasri; Piyamaporn Wipa; Sittiruk Roytrakul; Apirath Wangteeraprasert; Sutatip Pongcharoen; Jutaporn Ngoenkam
Journal:  BMC Mol Cell Biol       Date:  2022-07-28
  2 in total

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