Clinical and Radiographic Comparison Between Open Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion With Bilateral Facetectomies.

STUDY
DESIGN: Age- and sex-matched cohort study.
OBJECTIVES: To compare outcomes after open versus minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) with bilateral facetectomies.
METHODS: We retrospectively compared patients who underwent single- or 2-level MIS-TLIF with an age- and sex-matched open-TLIF cohort. Surgical data was collected for operative time, estimated blood loss (EBL), and drain use. Clinical outcomes included the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), length of stay (LOS), complications, and reoperations. Lumbar radiographs were measured for changes in global lumbar lordosis (LL) and segmental lordosis (SL).
RESULTS: Between 2016 and 2020, 38 MIS-TLIF patients were compared with 38 open-TLIF patients. No subfascial drain was used in the MIS-TLIF group (P < .001). The MIS-TLIF group had longer operative time (310.8 vs 276.5 minutes; P = .046) but less EBL (282.4 vs 420.8 mL; P = .007). LOS (P = .15), complication rates (P = .50), and revision rates (P = .17) were equivalent. VAS and ODI improved but did not differ between groups. In the open-TLIF group, LL and SL were restored or improved in 81.6% and 86.9% of cases, respectively. In the MIS-TLIF group, LL and SL were restored or improved in 86.8% and 97.4% of cases, respectively. There were no differences in changes in LL and SL between groups.
CONCLUSIONS: Compared with the age- and sex-matched open-TLIF cohort, patients undergoing MIS-TLIF had reduced EBL and subfascial drain use but increased operative time. There were no differences in complications, reoperations, or LOS. Both groups demonstrated improvement in VAS and ODI. MIS-TLIF with bilateral facetectomies provided equivalent improvements in global and segmental LL.

Introduction

Transforaminal lumbar interbody fusion (TLIF) was first introduced by Harms and Rolinger in 1982 as a modification of the posterior lumbar interbody fusion (PLIF) technique. Because the corridor to the disc space is more lateral, less dural retraction is required. Therefore, TLIF offers the theoretical advantage of fewer nerve root injuries in comparison to PLIF. Today, TLIF is often utilized in conjunction with posterolateral lumbar instrumented fusion procedures to facilitate arthrodesis. The addition of TLIF has been shown to increase the rates of radiographic fusion compared with posterolateral fusion alone. TLIF can be performed via an open or minimally invasive surgery (MIS) approach. The proposed advantages of MIS TLIF include less estimated blood loss (EBL), less postoperative pain, and shorter length of stay (LOS). However, as with any minimally invasive spine procedure, MIS TLIF has a steep learning curve and its own unique sets of challenges and complications.

One of the technical challenges of both open and MIS TLIF is optimal placement of the interbody cage to preserve or improve postoperative lumbar lordosis (LL). In a retrospective study by Madhavan et al, the authors reported that 57% of patients with normal preoperative LL developed postoperative kyphosis. Other studies have also documented kyphogenic effects of MIS TLIF. Lee et al reported an initial increase in the segmental lordotic angle after MIS TLIF, but this angle decreased significantly with time when compared with the preoperative segmental lordosis (SL). Vaishnav et al observed a decrease in segmental and regional lordosis after MIS TLIF with the use of static interbody cages in patients with high preoperative LL.

The aforementioned studies by Lee et al and Vaishnav et al involved MIS TLIF cases in which only unilateral facetectomy was performed (ie, unilateral MIS TLIF). In our experience, we always take down both facets (bilateral MIS TLIF) in order to compress across the fused segments after insertion of the interbody device. The present study evaluates the radiographic and clinical outcomes after bilateral MIS TLIF in comparison to an age- and sex-matched cohort of patients undergoing open TLIF with bilateral facetectomies. We hypothesize equivalent improvements in global and segmental LL after MIS TLIF compared to open TLIF with bilateral facetectomies.

Materials and Methods

This study was approved by our institutional review board. It was a retrospective cohort study comparing patients undergoing single- or 2-level TLIF with bilateral facetectomies via open versus MIS approaches at a single academic center. The 2 cohorts were matched by sex and age. Inclusion criteria were adult patients >18 years old who had 1- or 2-level TLIF. Patients were excluded if they had prior lumbar fusion surgeries or if they had 3 or more levels of interbody fusion.

The electronic medical records were reviewed to obtain basic demographic, clinical, and operative data. Standing neutral lumbar radiographs preoperatively and at final follow-up were reviewed for the following radiographic parameters: global LL and SL (Figure 1). LL was defined as the angle subtended by the inferior endplate line of T12 and the superior endplate line of S1. SL was defined as the angle subtended by the superior endplate line of the upper instrumented vertebra and the inferior endplate line of the lower instrumented vertebra. Taking the SEM previously reported for the Cobb method into consideration, only a change in LL or SL of ≥3° was considered significant. Clinical outcomes were assessed via the Visual Analog Scale (VAS) pain score and Oswestry Disability Index (ODI). The t-test and χ2 test were used to compare continuous and categorical variables, respectively. A probability of type I error <0.05 was utilized to assess statistical significance.

Figure 1.

Overview of the radiographic parameters of interest. This is an example for L4-5 transforaminal lumbar interbody fusion: A. Segmental lordosis (SL) is defined as the angle subtended by the superior endplate line of the upper instrumented vertebra and the inferior endplate line of the lower instrumented vertebra. B. Global lumbar lordosis (LL) is defined as the angle subtended by the inferior endplate line of T12 and the superior endplate line of S1.

Bilateral MIS TLIF Technique

Bilateral mini-open paramedian incisions were utilized in patients undergoing MIS TLIF, consistent with the Wiltse approach (Figure 2). Pedicle screws were placed with the assistance of an O-arm and surgical navigation. A screw shank/blade assembly was inserted at each level, and the blades were then attached to a retractor body. Light cables were subsequently placed into the retractor blades to improve visualization. With the retractor system assembled, bilateral complete facetectomies were performed, removing the entire superior articular process to clearly expose the disc space for the discectomy and interbody fusion. The pars was kept intact to protect the exiting nerve root. Adequate lateral recess decompression was ensured by visualizing the traversing nerve root on each side. In addition, we ensured adequate central decompression by removing the entire ligamentum flavum and undersurface of the lamina to allow for passage of a curved freer across the midline. Discectomy and interbody fusion were then performed from the most symptomatic side. Finally, rods were placed and compressed to restore lordosis. Of note, bilateral facetectomies were also performed for the open TLIF. The goal of the facetectomies in both groups was to access the disc space for interbody fusion and to facilitate restoration of LL with compression after the interbody fusion procedure was completed.

Figure 2.

Intraoperative images of minimally invasive transforaminal lumbar interbody fusion: A. Bilateral mini-open paramedian incisions are made. Pedicle screws are placed under image guidance. A screw shank/blade assembly is inserted at each level. B. Intraoperative posteroanterior fluoroscopic X-ray demonstrating the screw shank/blade assembly. C. Complete facetectomy is performed on each side using an osteotome and Kerrison rongeur. D. Central decompression is achieved by removing the ligamentum flavum and undersurface of the lamina to allow for passage of a curved freer across the midline.

Results

A total of 38 consecutive patients who underwent MIS TLIF between 2016 and 2020 (25 single level, 13 two level) were compared with a matched cohort of 38 patients who underwent open TLIF (25 single level, 13 two level). The mean age (62.1 vs 61.4 years; P = .75) and gender distributions (23 female and 15 male patients) were expectedly similar between the 2 cohorts. The BMIs were also comparable (32.3 vs 32.2 kg/m2; P = .95). The mean follow-up periods for the MIS and open cohorts were 350 and 393 days, respectively (P = .55). In each cohort, the surgical diagnosis was lumbar spondylosis alone (n = 16, 42.1%) or lumbar spondylosis with degenerative spondylolisthesis (n = 22, 57.9%; Table 1). Both groups had the same distribution of primary (n = 35, 92.1%) and revision (n = 3, 7.9%) lumbar spine surgeries.

Table 1.

Demographic Comparison Between the 2 Groups.

Characteristic	Open TLIF	MIS TLIF	Significance
Cases	38	38
Age	61.4	62.1	P = .75
Sex	23 F:15 M	23 F:15 M
BMI	32.2	32.3	P = .95
Diagnosis	Spondylosis alone: 16With spondylolisthesis: 22	Spondylosis alone: 16With spondylolisthesis: 22
Case type	Primary: 35Revision: 3	Primary: 35Revision: 3
Length of stay	3.6	3.1	P = .15
Follow-up	392.7	350.7	P = .55
Change in VAS	3.2	3.5	P = .68
Change in ODI	9.3	7.0	P = .47
Complication	6	4	P = .50
Reoperation	4	1	P = .17

Abbreviations: BMI, body mass index; F, female; M, male; MIS, minimally invasive surgery; ODI, Oswestry Disability Index; TLIF, transforaminal lumbar interbody fusion; VAS, Visual Analog Scale.

No suprafascial or subfascial drain was used in the MIS group, compared with 97.4% (37 of 38 cases) in the open group (P < .001). The operative time was shorter in the open group (276.5 vs 310.8 minutes; P = .046), whereas the EBL was less in the MIS group (282.4 vs 420.8 mL; P = .007). However, there was an equal rate of intraoperative transfusion of packed red blood cells (pRBCs; 3 cases per group, 7.9%). The early surgical complication rates for the MIS and open cohorts were 10.5% versus 15.8% (P = .50). The revision rates for the MIS and open cohorts were 2.6% versus 10.5% (P = .17; Table 2).

Table 2.

Operative Comparison Between the 2 Groups.

Characteristic	Open TLIF	MIS TLIF	Significance
Cases	38	38
Single level	25	25
Two level	13	13
Drain	37	0	P < .001
Estimated blood loss	420.8	282.4	P = .007
Intraoperative transfusion	3	3
Operative time	276.5	310.8	P = .046

Abbreviations: MIS, minimally invasive surgery; TLIF, transforaminal lumbar interbody fusion.

Clinically, there were statistically significant improvements in VAS in the MIS (6.1 to 2.5; P < .001) and open (5.9 to 2.7; P < .001) cohorts. However, VAS improvement did not differ between groups (3.5 vs 3.2; P = .68). Likewise, there were statistically significant improvements in ODI in the MIS (23.0 to 14.8; P = .004) and open (25.2 to 17.1; P < .001) cohorts that did not differ between groups (7.0 vs 9.25, P = .47; Table 1). The LOS was also similar (3.6 vs 3.1 days; P = .15). However, 23.7% of MIS patients were discharged on postoperative day 1, compared with 2.6% in the open cohort.

The changes in LL and SL are summarized in Table 3. Radiographically, in the open group, the LL was restored or improved in 81.6% of the cases and SL in 86.9% of the cases. Likewise, in the MIS group, the LL and SL were restored or improved in 86.8% and 97.4% of the cases, respectively (Table 4). There were no differences in the changes in LL and SL between groups. Subgroup analysis did not demonstrate any statistically significant differences in the change in LL and SL for diagnosis (spondylosis alone vs spondylosis with spondylolisthesis) or TLIF level (single- vs 2-level; Table 5).

Table 3.

Radiographic Comparison Between the 2 Groups.

Parameter	Open TLIF	MIS TLIF	Significance
Preoperative LL	50.9 ± 11.9	53.8 ± 10.7	P = .26
Postoperative LL	54.2 ± 11.9	58.2 ± 10.5	P = .13
Change in LL	3.4 ± 6.0	4.4 ± 5.8	P = .47
Preoperative SL	24.1 ± 7.5	21.4 ± 8.6	P = .14
Postoperative SL	27.1 ± 6.8	25.3 ± 8.9	P = .32
Change in SL	3.0 ± 6.2	3.9 ± 3.9	P = .46

Abbreviations: MIS, minimally invasive surgery; LL, global lumbar lordosis; SL, segmental lordosis; TLIF, transforaminal lumbar interbody fusion.

Table 4.

Changes in Global LL and SL With Surgery.a

Parameter	Open TLIF	MIS TLIF
Lumbar lordosis (LL)
Increased	23 (60.5%)	23 (60.5%)
Unchanged	8 (21.1%)	10 (26.3%)
Decreased	7 (18.4%)	5 (13.2%)
Segmental lordosis (SL)
Increased	21 (55.3%)	25 (65.8%)
Unchanged	12 (31.6%)	12 (31.6%)
Decreased	5 (13.2%)	1 (2.6%)

Abbreviations: MIS, minimally invasive surgery; TLIF, transforaminal lumbar interbody fusion.

a After surgery, an increase or decrease in LL or SL is defined as a change in measurement of ≥3° or ≤3° from preoperative, respectively.

Table 5.

Comparison in the Change in Global LL and SL by Diagnosis (Spondylosis Alone vs Spondylosis With Spondylolisthesis) and TLIF Levels (Single- vs 2-Level).

Parameter	Open TLIF	MIS TLIF	Significance
Spondylosis	n = 16	n = 16
Change in LL	2.0 ± 6.3	1.9 ± 5.3	P = .98
Change in SL	1.0 ± 6.1	2.8 ± 3.7	P = .32
Spondylolisthesis	n = 22	n = 22
Change in LL	4.4 ± 5.9	6.1 ± 5.7	P = .32
Change in SL	4.5 ± 6.1	4.7 ± 4.0	P = .89
Single level	n = 25	n = 25
Change in LL	3.1 ± 6.0	3.7 ± 6.0	P = .73
Change in SL	2.2 ± 6.5	3.2 ± 3.5	P = .50
Two level	n = 13	n = 13
Change in LL	3.9 ± 6.4	5.7 ± 5.5	P = .46
Change in SL	4.5 ± 5.7	5.2 ± 4.6	P = .74

Abbreviations: LL, lumbar lordosis; MIS, minimally invasive surgery; SL, segmental lordosis; TLIF, transforaminal lumbar interbody fusion.

Discussion

The results from this study highlight several key differences between MIS and open TLIF. Consistent with previously published studies, one of the main advantages of MIS TLIF is the decrease in blood loss. The MIS group in our study had significantly less blood loss compared with the open cohort. However, the intraoperative transfusion rates were similar between groups. At our institution, we administer systemic tranexamic acid prior to making an incision for both MIS and open TLIF procedures and have noticed a decrease in the need for intraoperative pRBC transfusions. In addition, we routinely use cell saver for autotransfusion to avoid allogeneic blood transfusions. Because of the decrease in blood loss, no suprafascial or subfascial drain was used in the MIS cohort. A prospective randomized clinical study by Hung et al demonstrated no significant differences in perioperative outcomes (eg, operative time, EBL, LOS, and complications) in MIS TLIF cases with and without closed suction wound drainage. In fact, on average, patients without drains ambulated a day earlier than patients with drains after MIS TLIF. Interestingly, the operative time in the MIS group was significantly higher than the open group. In the literature, there are published studies in support of MIS TLIF or open TLIF in terms of surgical duration. In our experience, MIS TLIF takes longer because we are performing bilateral facetectomies rather than unilateral facetectomies. Furthermore, our study included the first 38 consecutive MIS TLIF patients operated on by 1 provider, and 1 study suggests that it takes roughly that many number of cases to improve operative time and proficiency. Although not directly addressed in this study, MIS TLIF certainly increases the ionizing radiation exposure for both surgeons and patients. Therefore, this should be carefully discussed when counseling patients regarding the risks and benefits between open versus MIS TLIF.

In the age- and sex-matched MIS and open cohorts, the early surgical complication rates and revision rates were comparable. However, the types of complications were notably different. Specifically, there were more incidental durotomies in the MIS group (3 of 4 complications, 75%), whereas there were more deep wound infections and seromas in the open group (5 of 6 complications, 83.3%). Specifically, in the open cohort, 3 patients had surgical site infection, and 2 patients developed symptomatic seroma; all these patients had subfascial drains during their index surgery and required formal irrigation and debridement to treat their complication. There was 1 MIS TLIF patient without a subfascial drain who developed a large seroma causing lumbar radiculopathy requiring irrigation and debridement. We believe that the use of a subfascial drain should be considered on a case-by-case basis, irrespective of whether the TLIF procedure is performed open or MIS.

Previously published studies have shown that MIS TLIF is associated with lower complication rates than open surgery; however, the difference is not statistically significant. Studies comparing open versus MIS lumbar discectomy have reported higher rates of durotomy and lower rates of wound infection. A systematic review by Parker et al concluded that there was a significant decrease in the incidence of surgical site infection after MIS compared with open TLIF. Thus, MIS TLIF may be a better option in patients with high risks for perioperative wound complications, such as obese patients. In our study, there was 1 reoperation in the MIS cohort for adjacent segment disease (ASD), compared with 4 reoperations in the open cohort for ASD (1 case) and pseudarthrosis (3 cases). MIS techniques have also been shown to decrease the incidence of ASD following lumbar spine surgeries compared with open approaches because of less soft-tissue disruption, although this conclusion was not observed in our study. During MIS TLIF, when pedicle screws are placed percutaneously, careful attention needs to be paid to avoid iatrogenic superior facet joint violation, which is a known risk factor for ASD. Whereas revision for pseudarthrosis was only seen in the open cohort in our study, pseudarthrosis is also a potential long-term complication of MIS TLIF.

In our study, there were statistically significant improvements in VAS and ODI after MIS and open TLIF. However, the changes in VAS and ODI were comparable between groups, suggesting equivalent outcomes between MIS and open TLIF procedures. This finding of comparable clinical outcomes has been published in multiple studies. Interestingly, although the change in VAS did not differ between groups, Cheng et al showed that the total administration of morphine-equivalent pain medication in the hospital tended to be lower in the MIS group. Another interesting finding in our study is the equivalent LOS between the 2 groups, although more MIS patients were discharged on postoperative day 1. However, the majority of publications have favored a lower LOS after MIS TLIF when compared with open procedures. Eckman et al published a same-day discharge rate of 73% (808 of 1114 patients) after single- or 2-level MIS TLIF. Siemionow et al identified several predictors of LOS greater than 24 hours after MIS TLIF, including higher VAS, higher total fluids at the end of the case, lower preoperative hemoglobin, and lower mean percentage of fraction of inspired oxygen. Thus, optimization of certain modifiable factors could potentially optimize time to discharge. Other noted benefits of MIS TLIF are earlier mobilization, quicker return to work, and reduced costs.

As previously discussed, TLIF can potentially be kyphogenic, with one study concluding that 57% of patients with normal LL preoperatively developed kyphosis postoperatively. Dorward et al observed that patients who had TLIF performed in the L3-S1 region actually lost lordosis postoperatively. This is a problem also observed in MIS TLIF, leading some to believe “TLIF is kyphosing.” However, open TLIF with bilateral facetectomies, when done appropriately, is a common way of restoring LL and sagittal balance. We have applied this to our MIS TLIF technique and perform bilateral facetectomies in all MIS TLIF cases. In our study, we found that MIS TLIF with bilateral facetectomies preserved or improved LL in 86.8% of cases and SL in 97.4% of cases, similar in comparison to open TLIF with bilateral facetectomies (Figure 3). Thus, one strategy during open or MIS TLIF to restore LL and SL is to perform bilateral facetectomies. This, in our experience, allows for greater compression across the instrumented vertebrae to create a more favorable LL postoperatively. Although this study demonstrates the similarities and differences between MIS and open TLIF, it does not directly compare MIS TLIF with unilateral versus bilateral facetectomies. In fact, other factors may influence the change in lordosis after TLIF, including the type of cage used and where the cage is placed. Future studies should focus on directly comparing unilateral versus bilateral MIS TLIF to determine the significance of bilateral facetectomies on clinical and radiographic outcomes. Another limitation of this study is that although we matched for sex and age, there could be other potential confounding factors that might be unevenly distributed between the 2 groups being compared.

Figure 3.

Standing neutral lumbar radiographs of patients who underwent open and minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) demonstrating improvement in global and segmental lordosis postoperatively. Preoperative (A) and postoperative (B) lateral radiographs of a patient who had L4-5 open TLIF. Preoperative (C) and postoperative (D) lateral radiographs of a patient who had L3-5 MIS TLIF.

In summary, in comparison to an age- and sex-matched open TLIF cohort, patients undergoing single- or 2-level MIS TLIF had significantly reduced EBL and subfascial drain use but increased operative times. There were no significant differences in transfusion rates, surgical complication rates, revision rates, or LOS. Both groups demonstrated significant improvements in VAS and ODI; however, the changes in VAS and ODI were comparable between groups. Finally, MIS TLIF with bilateral facetectomies provided equivalent improvements in global and segmental LL when compared with open TLIF with bilateral facetectomies.