Shiti Zhang1, Xin Li2, Huihuan Luo2, Zhong-Ze Fang3, Hao Ai1. 1. Jinzhou Medical University, Jinzhou City, Liaoning, China. 2. Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China. 3. Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. Electronic address: fangzhongze@tmu.edu.cn.
Abstract
BACKGROUND: We aimed to estimate the associations between aromatic amino acids (AAAs) and diabetic nephropathy (DN) in patients with type 2 diabetes (T2D). METHODS: We collected clinical and metabolomic data from 132 healthy subjects (HS group), 132 type 2 diabetes patients without diabetic nephropathy (T2D group) and 132 diabetic nephropathy patients (DN group) in tertiary hospital from May 2015 to August 2016. The odds ratio (OR) and 95% confidence interval (CI) were obtained by logistic regression. RESULTS: The odds ratio of tyrosine for DN increased gradually. High tyrosine was associated with an increased OR of DN (model 3, OR:0.329, 95%CI, 0.144-0.750) when comparing extreme quantiles. CONCLUSION: In Chinese patients with T2D, elevated tyrosine was associated with increased risk of DN.
BACKGROUND: We aimed to estimate the associations between aromatic amino acids (AAAs) and diabetic nephropathy (DN) in patients with type 2 diabetes (T2D). METHODS: We collected clinical and metabolomic data from 132 healthy subjects (HS group), 132 type 2 diabetespatients without diabetic nephropathy (T2D group) and 132 diabetic nephropathypatients (DN group) in tertiary hospital from May 2015 to August 2016. The odds ratio (OR) and 95% confidence interval (CI) were obtained by logistic regression. RESULTS: The odds ratio of tyrosine for DN increased gradually. High tyrosine was associated with an increased OR of DN (model 3, OR:0.329, 95%CI, 0.144-0.750) when comparing extreme quantiles. CONCLUSION: In Chinese patients with T2D, elevated tyrosine was associated with increased risk of DN.