Literature DB >> 32672326

Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis.

Cody Lemke1, Owen Whitham1, Reuben J Peters1.   

Abstract

The class II diterpene cyclase (DTC) from pleuromutilin biosynthesis uniquely mediates 'A' ring contraction of the initially formed decalin bicycle, yielding mutildienyl diphosphate (MPP). Catalysis requires a divalent metal cation co-factor. Intriguingly, selectively with magnesium, this DTC catalyzes ring expansion/contraction between MPP and halimadienyl diphosphate, providing some catalytic insight.

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Year:  2020        PMID： 32672326      PMCID： PMC7430159          DOI： 10.1039/d0ob01422b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  10 in total

Review 1.  Two rings in them all: the labdane-related diterpenoids.

Authors:  Reuben J Peters
Journal:  Nat Prod Rep       Date:  2010-10-01       Impact factor: 13.423

Review 2.  Pleuromutilins: Potent Drugs for Resistant Bugs-Mode of Action and Resistance.

Authors:  Susanne Paukner; Rosemarie Riedl
Journal:  Cold Spring Harb Perspect Med       Date:  2017-01-03       Impact factor: 6.915

3.  Some studies in the biosynthesis of terpenes and related compounds.

Authors:  D Arigoni
Journal:  Pure Appl Chem       Date:  1968       Impact factor: 2.453

4.  Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi.

Authors:  Momoka Yamane; Atsushi Minami; Chengwei Liu; Taro Ozaki; Ichiro Takeuchi; Tae Tsukagoshi; Tetsuo Tokiwano; Katsuya Gomi; Hideaki Oikawa
Journal:  Chembiochem       Date:  2017-10-23       Impact factor: 3.164

5.  Synergistic substrate inhibition of ent-copalyl diphosphate synthase: a potential feed-forward inhibition mechanism limiting gibberellin metabolism.

Authors:  Sladjana Prisic; Reuben J Peters
Journal:  Plant Physiol       Date:  2007-03-23       Impact factor: 8.340

Review 6.  Terpenoid synthase structures: a so far incomplete view of complex catalysis.

Authors:  Yang Gao; Richard B Honzatko; Reuben J Peters
Journal:  Nat Prod Rep       Date:  2012-08-21       Impact factor: 13.423

7.  Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis.

Authors:  Meirong Jia; Kevin C Potter; Reuben J Peters
Journal:  Metab Eng       Date:  2016-04-07       Impact factor: 9.783

8.  Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase.

Authors:  Meimei Xu; Meirong Jia; Young J Hong; Xihou Yin; Dean J Tantillo; Philip J Proteau; Reuben J Peters
Journal:  Org Lett       Date:  2018-02-01       Impact factor: 6.005

9.  Product Rearrangement from Altering a Single Residue in the Rice syn-Copalyl Diphosphate Synthase.

Authors:  Kevin C Potter; Meirong Jia; Young J Hong; Dean Tantillo; Reuben J Peters
Journal:  Org Lett       Date:  2016-02-15       Impact factor: 6.005

10.  Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives.

Authors:  Fabrizio Alberti; Khairunisa Khairudin; Edith Rodriguez Venegas; Jonathan A Davies; Patrick M Hayes; Christine L Willis; Andy M Bailey; Gary D Foster
Journal:  Nat Commun       Date:  2017-11-28       Impact factor: 14.919
  10 in total

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