Literature DB >> 3265919

Arginine is a physiological precursor of endothelium-derived nitric oxide.

H H Schmidt1, H Nau, W Wittfoht, J Gerlach, K E Prescher, M M Klein, F Niroomand, E Böhme.   

Abstract

ATP dose dependently stimulated the formation and release of nitric oxide (NO) from perfused rabbit aorta. L-Canavanine, an inhibitor of various L-arginine-utilizing enzymes, abolished basal and ATP-induced NO formation and release. ATP increased the accumulation of presumably NO-derived NO2- in the medium of primary cultures of bovine aortic endothelial cells. 15NO, 15NO2- and 15NO3- formation was found when L-[guanido-15N2]arginine was added to the culture medium. We conclude that the terminal guanidino nitrogens of L-arginine are the physiological precursors of endothelium-derived NO.

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Year:  1988        PMID： 3265919     DOI： 10.1016/0014-2999(88)90101-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  63 in total

1.  The cytosol of N1E-115 neuroblastoma cells synthesizes an EDRF-like substance that relaxes rabbit aorta.

Authors:  U Förstermann; K Ishii; L D Gorsky; F Murad
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

2.  Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

Authors:  J S Pollock; U Förstermann; J A Mitchell; T D Warner; H H Schmidt; M Nakane; F Murad
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

3.  L-arginine induces relaxation of rat aorta possibly through non-endothelial nitric oxide formation.

Authors:  H Moritoki; H Ueda; T Yamamoto; T Hisayama; S Takeuchi
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739

4.  Effects of pyrimidines on the guinea-pig coronary vasculature.

Authors:  A J Vials; G Burnstock
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

5.  Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells.

Authors:  M A Awolesi; W C Sessa; B E Sumpio
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

6.  Assessment of renal dopaminergic system activity in the nitric oxide-deprived hypertensive rat model.

Authors:  P Soares-da-Silva; M Pestana; M A Vieira-Coelho; M H Fernandes; A Albino-Teixeira
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

7.  Nitric oxide synthase activity is inducible in rat, but not rabbit alveolar macrophages, with a concomitant reduction in arginase activity.

Authors:  C Hey; I Wessler; K Racké
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-06       Impact factor: 3.000

8.  Human and rat macrophages mediate fungistatic activity against Rhizopus species differently: in vitro and ex vivo studies.

Authors:  P G Jorens; J R Boelaert; V Halloy; R Zamora; Y J Schneider; A G Herman
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

9.  Muramyldipeptide and granulocyte-macrophage colony-stimulating factor enhance interferon-gamma-induced nitric oxide production by rat alveolar macrophages.

Authors:  P G Jorens; F J van Overveld; H Bult; P A Vermeire; A G Herman
Journal:  Agents Actions       Date:  1993-01

10.  Bacterial endotoxin rapidly stimulates prolonged endothelium-dependent vasodilatation in the rat isolated perfused heart.

Authors:  A R Baydoun; R D Foale; G E Mann
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739
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