Ali Safavi Naeini1, Mahboobeh Karimi-Galougahi1, Nasim Raad1, Jahangir Ghorbani1, Ayeh Taraghi2, Sara Haseli3, Golfam Mehrparvar4, Mehrdad Bakhshayeshkaram3. 1. Department of Otolaryngology, Masih Daneshvari Hospital, Tehran, Iran; Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Otolaryngology, Masih Daneshvari Hospital, Tehran, Iran; Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: dr.a.taraghi@gmail.com. 3. Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Department of Otolaryngology, Masih Daneshvari Hospital, Tehran, Iran.
Abstract
OBJECTIVE: Olfactory dysfunction in coronavirus disease-2019 (COVID-19) is poorly understood. Thus, mechanistic data are needed to elucidate the pathophysiological drivers of anosmia of COVID-19. METHODS: We performed the current study in patients who presented with anosmia and COVID-19 as documented by the polymerase chain reaction (PCR) assay between April 1st and May 15st, 2020. We assessed for the conductive causes of anosmia with computed tomography (CT) of paranasal sinuses. RESULTS: 49 patients who presented with anosmia and positive PCR assay for COVID-19 were included. The average age was 45 ± 12.2 years. Complete anosmia was present in 85.7% of patients and 91.8% of patients reported sudden onset of olfactory dysfunction. Taste disturbance was common (75.5%). There were no significant pathological changes in the paranasal sinuses on CT scans. Olfactory cleft and ethmoid sinuses appeared normal while in other sinuses, partial opacification was detected only in some cases. CONCLUSION: We did not find significant mucosal changes or olfactory cleft abnormality on CT imaging in patients with anosmia of COVID-19. Conductive causes of anosmia (i.e., mucosal disease) do not seem play a significant role in anosmia of COVID-19.
OBJECTIVE:Olfactory dysfunction in coronavirus disease-2019 (COVID-19) is poorly understood. Thus, mechanistic data are needed to elucidate the pathophysiological drivers of anosmia of COVID-19. METHODS: We performed the current study in patients who presented with anosmia and COVID-19 as documented by the polymerase chain reaction (PCR) assay between April 1st and May 15st, 2020. We assessed for the conductive causes of anosmia with computed tomography (CT) of paranasal sinuses. RESULTS: 49 patients who presented with anosmia and positive PCR assay for COVID-19 were included. The average age was 45 ± 12.2 years. Complete anosmia was present in 85.7% of patients and 91.8% of patients reported sudden onset of olfactory dysfunction. Taste disturbance was common (75.5%). There were no significant pathological changes in the paranasal sinuses on CT scans. Olfactory cleft and ethmoid sinuses appeared normal while in other sinuses, partial opacification was detected only in some cases. CONCLUSION: We did not find significant mucosal changes or olfactory cleft abnormality on CT imaging in patients with anosmia of COVID-19. Conductive causes of anosmia (i.e., mucosal disease) do not seem play a significant role in anosmia of COVID-19.
Authors: Rushi Patel; Christina H Fang; Jordon G Grube; Jean Anderson Eloy; Wayne D Hsueh Journal: Oper Tech Otolayngol Head Neck Surg Date: 2022-04-28
Authors: J M Plasencia-Martínez; À Rovira; P Caro Domínguez; I Barber; E García-Garrigós; J J Arenas-Jiménez Journal: Radiologia (Engl Ed) Date: 2021-05-19
Authors: Maxime Niesen; Nicola Trotta; Antoine Noel; Tim Coolen; Georges Fayad; Gil Leurkin-Sterk; Isabelle Delpierre; Sophie Henrard; Niloufar Sadeghi; Jean-Christophe Goffard; Serge Goldman; Xavier De Tiège Journal: Eur J Nucl Med Mol Imaging Date: 2021-01-04 Impact factor: 9.236