Ellen Driessen1, Jack J M Dekker2, Jaap Peen2, Henricus L Van3, Giuseppe Maina4, Gianluca Rosso4, Sylvia Rigardetto5, Francesco Cuniberti4, Veronica G Vitriol6, Ramon U Florenzano7, Antonio Andreoli8, Yvonne Burnand8, Jaime López-Rodríguez9, Valerio Villamil-Salcedo9, Jos W R Twisk10, Pim Cuijpers11. 1. Department of Clinical Psychology, Behavioural Science Institute, Radboud University, Nijmegen, Netherlands; Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. Electronic address: e.driessen@psych.ru.nl. 2. Department of Research, Arkin Mental Health Care, Amsterdam, Netherlands. 3. NPI, Arkin Mental Health Care, Amsterdam, Netherlands. 4. Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy; Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy. 5. Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy. 6. Medical School, University of Talca, Talca, Chile. 7. Department of Psychiatry and Mental Health, School of Medicine, Universidad de Los Andes, Santiago de Chile, Chile. 8. Psychiatric Services, Geneva University Hospital, Geneva, Switzerland. 9. National Institute of Psychiatry, Mexico City, Mexico. 10. Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers, Amsterdam, Netherlands. 11. Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Abstract
PURPOSE: We examined the efficacy of adding short-term psychodynamic psychotherapy (STPP) to antidepressants in the treatment of depression by means of a systematic review and meta-analysis of individual participant data, which is currently considered the most reliable method for evidence synthesis. RESULTS: A thorough systematic literature search resulted in 7 studies comparing combined treatment of antidepressants and STPP versus antidepressant mono-therapy (n = 3) or versus antidepressants and brief supportive psychotherapy (n = 4). Individual participant data were obtained for all these studies and totaled 482 participants. Across the total sample of studies, combined treatment of antidepressants and STPP was found significantly more efficacious in terms of depressive symptom levels at both post-treatment (Cohen's d = 0.26, SE = 0.10, p = .01) and follow-up (d = 0.50, SE = 0.10, p < .001). This effect was most apparent at follow-up and in studies examining STPP's specific treatment efficacy. Effects were still apparent in analyses that controlled for risk of bias and STPP quality in the primary studies. CONCLUSIONS: These findings support the evidence-base of adding STPP to antidepressants in the treatment of depression. However, further studies are needed, particularly assessing outcome measures other than depression and cost-effectiveness, as well as examining the relative merits of STPP versus other psychotherapies as added to antidepressants.
PURPOSE: We examined the efficacy of adding short-term psychodynamic psychotherapy (STPP) to antidepressants in the treatment of depression by means of a systematic review and meta-analysis of individual participant data, which is currently considered the most reliable method for evidence synthesis. RESULTS: A thorough systematic literature search resulted in 7 studies comparing combined treatment of antidepressants and STPP versus antidepressant mono-therapy (n = 3) or versus antidepressants and brief supportive psychotherapy (n = 4). Individual participant data were obtained for all these studies and totaled 482 participants. Across the total sample of studies, combined treatment of antidepressants and STPP was found significantly more efficacious in terms of depressive symptom levels at both post-treatment (Cohen's d = 0.26, SE = 0.10, p = .01) and follow-up (d = 0.50, SE = 0.10, p < .001). This effect was most apparent at follow-up and in studies examining STPP's specific treatment efficacy. Effects were still apparent in analyses that controlled for risk of bias and STPP quality in the primary studies. CONCLUSIONS: These findings support the evidence-base of adding STPP to antidepressants in the treatment of depression. However, further studies are needed, particularly assessing outcome measures other than depression and cost-effectiveness, as well as examining the relative merits of STPP versus other psychotherapies as added to antidepressants.
Authors: Dan J Stein; Steven J Shoptaw; Daniel V Vigo; Crick Lund; Pim Cuijpers; Jason Bantjes; Norman Sartorius; Mario Maj Journal: World Psychiatry Date: 2022-10 Impact factor: 79.683
Authors: Ellen Driessen; Zachary D Cohen; Myrna M Weissman; John C Markowitz; Erica S Weitz; Steven D Hollon; Dillon T Browne; Paola Rucci; Carolina Corda; Marco Menchetti; R Michael Bagby; Lena C Quilty; Michael W O'Hara; Caron Zlotnick; Teri Pearlstein; Marc B J Blom; Mario Altamura; Carlos Gois; Lon S Schneider; Jos W R Twisk; Pim Cuijpers Journal: BJPsych Open Date: 2021-02-19
Authors: Ellen Driessen; Zachary D Cohen; Lorenzo Lorenzo-Luaces; Steven D Hollon; David A Richards; Keith S Dobson; Sona Dimidjian; Jaime Delgadillo; Fernando L Vázquez; Kathleen McNamara; John J Horan; Pauline Gardner; Tian P Oei; Anuj H P Mehta; Jos W R Twisk; Ioana A Cristea; Pim Cuijpers Journal: BJPsych Open Date: 2022-08-10
Authors: Ole Jakob Storebø; Johanne Pereira Ribeiro; Mickey T Kongerslev; Jutta Stoffers-Winterling; Mie Sedoc Jørgensen; Klaus Lieb; Anthony Bateman; Richard Kirubakaran; Nicolas Dérian; Eirini Karyotaki; Pim Cuijpers; Erik Simonsen Journal: BMJ Open Date: 2021-06-21 Impact factor: 2.692