Ali Yılmaz1, Hatice Yılmaz2, Salim Başol Tekin1, Mehmet Bilici1. 1. Department of Medical Oncology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey. 2. Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, Efeler, Aydın, Turkey.
Abstract
Aim: To investigate the prognostic significance of pretreatment hemoglobin (HB)-to-red cell distribution width (RDW) ratio (HRR) in patients with muscle-invasive bladder cancer (MIBC). Materials & methods: The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), prognostic nutritional index, HRR, HB and RDW were analyzed to assess their prognostic value using the Kaplan-Meier curves and Cox-regression analysis in 152 patients with MIBC. Results: Univariate analysis showed that the progression-free survival (PFS) was associated with NLR, SII, HRR, RDW, whereas overall survival (OS) was associated with NLR, SII, prognostic nutritional index, HRR, HB, RDW. In multivariate analysis, HRR was found to be an independent prognostic factor for both PFS and OS. Conclusion: HRR is a new prognostic factor that can be used to predict PFS/OS in MIBC.
Aim: To investigate the prognostic significance of pretreatment hemoglobin (HB)-to-red cell distribution width (RDW) ratio (HRR) in patients with muscle-invasive bladder cancer (MIBC). Materials & methods: The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), prognostic nutritional index, HRR, HB and RDW were analyzed to assess their prognostic value using the Kaplan-Meier curves and Cox-regression analysis in 152 patients with MIBC. Results: Univariate analysis showed that the progression-free survival (PFS) was associated with NLR, SII, HRR, RDW, whereas overall survival (OS) was associated with NLR, SII, prognostic nutritional index, HRR, HB, RDW. In multivariate analysis, HRR was found to be an independent prognostic factor for both PFS and OS. Conclusion: HRR is a new prognostic factor that can be used to predict PFS/OS in MIBC.
Entities:
Keywords:
bladder cancer; hemoglobin; lymphocyte; muscle invasive; neutrophil; prognosis; prognostic nutritional index; red cell distribution width; survival; systemic immune-inflammation index