Literature DB >> 32646923

Neoepitopes as Difference Makers for General Cancer Vaccines?

Jessica N Filderman1, Walter J Storkus2,3,4,5,6.   

Abstract

The cancer mutanome has been associated with disease prognosis as well as response to interventional immunotherapy and provides a substrate for development of personalized vaccines targeting tumor neoepitopes. Recent findings suggest that neoantigen-based vaccines may represent general interventional approaches for patients with solid cancers, regardless of their inherent mutational burden.See related article by Fang et al., p. 4511. ©2020 American Association for Cancer Research.

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Year:  2020        PMID： 32646923      PMCID： PMC7484287          DOI： 10.1158/1078-0432.CCR-20-2127

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  5 in total

1.  Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

Authors:  Dung T Le; Jennifer N Durham; Kellie N Smith; Hao Wang; Bjarne R Bartlett; Laveet K Aulakh; Steve Lu; Holly Kemberling; Cara Wilt; Brandon S Luber; Fay Wong; Nilofer S Azad; Agnieszka A Rucki; Dan Laheru; Ross Donehower; Atif Zaheer; George A Fisher; Todd S Crocenzi; James J Lee; Tim F Greten; Austin G Duffy; Kristen K Ciombor; Aleksandra D Eyring; Bao H Lam; Andrew Joe; S Peter Kang; Matthias Holdhoff; Ludmila Danilova; Leslie Cope; Christian Meyer; Shibin Zhou; Richard M Goldberg; Deborah K Armstrong; Katherine M Bever; Amanda N Fader; Janis Taube; Franck Housseau; David Spetzler; Nianqing Xiao; Drew M Pardoll; Nickolas Papadopoulos; Kenneth W Kinzler; James R Eshleman; Bert Vogelstein; Robert A Anders; Luis A Diaz
Journal:  Science       Date:  2017-06-08       Impact factor: 47.728

2.  A Pan-cancer Clinical Study of Personalized Neoantigen Vaccine Monotherapy in Treating Patients with Various Types of Advanced Solid Tumors.

Authors:  Yong Fang; Fan Mo; Jiawei Shou; Huimin Wang; Kai Luo; Shanshan Zhang; Ning Han; Hongsen Li; Shengli Ye; Zhan Zhou; Rongchang Chen; Lin Chen; Liang Liu; Huina Wang; Hongming Pan; Shuqing Chen
Journal:  Clin Cancer Res       Date:  2020-05-21       Impact factor: 12.531

Review 3.  The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters.

Authors:  Arnold J Levine; Nancy A Jenkins; Neal G Copeland
Journal:  Cancer Cell       Date:  2019-01-14       Impact factor: 31.743

Review 4.  Neoantigens in cancer immunotherapy.

Authors:  Ton N Schumacher; Robert D Schreiber
Journal:  Science       Date:  2015-04-03       Impact factor: 47.728

5.  Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display.

Authors:  Stina L Wickström; Tanja Lövgren; Michael Volkmar; Bruce Reinhold; Jonathan S Duke-Cohan; Laura Hartmann; Janina Rebmann; Anja Mueller; Jeroen Melief; Roeltje Maas; Maarten Ligtenberg; Johan Hansson; Rienk Offringa; Barbara Seliger; Isabel Poschke; Ellis L Reinherz; Rolf Kiessling
Journal:  Front Immunol       Date:  2019-12-11       Impact factor: 7.561
  5 in total

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