Justin S Golub1, Rahul K Sharma1, Brady Q Rippon2, Adam M Brickman3, José A Luchsinger2,4. 1. Department of Otolaryngology-Head and Neck Surgery, Columbia University, New York, New York, U.S.A. 2. Department of Medicine, Columbia University, New York, New York, U.S.A. 3. Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and the Gertrude H. Sergievsky Center; Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia University, New York, New York, U.S.A. 4. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, U.S.A.
Abstract
OBJECTIVES/HYPOTHESIS: To analyze the association between early audiometric age-related hearing loss and brain β-amyloid, the pathologic hallmark of Alzheimer's disease (AD). STUDY DESIGN: Cross-sectional analysis of a prospective cohort study. METHODS: A cross-sectional analysis was performed on 98 participants in a cohort study of hearing and brain biomarkers of AD. The primary outcome was whole brain β-amyloid standardized uptake value ratio (SUVR) on positron emission tomography (PET). The exposure was hearing, as measured by either pure-tone average or word recognition score in the better ear. Covariates included age, gender, education, cardiovascular disease, and hearing aid use. Linear regression was performed to analyze the association between β-amyloid and hearing, adjusting for potentially confounding covariates. RESULTS: The mean age ± standard deviation was 64.6 ± 3.5 years. In multivariable regression, adjusting for demographics, education, cardiovascular disease, and hearing aid use, whole brain β-amyloid SUVR increased by 0.029 (95% confidence interval [CI]: 0.003-0.056) for every 10 dB increase in pure-tone average (P = .030). Similarly, whole brain β-amyloid SUVR increased by 0.061 (95% CI: 0.009-0.112) for every 10% increase in word recognition score (P = .012). CONCLUSIONS: Worsening hearing was associated with higher β-amyloid burden, a pathologic hallmark of AD, measured in vivo with PET scans. LEVEL OF EVIDENCE: 3 Laryngoscope, 131:633-638, 2021.
OBJECTIVES/HYPOTHESIS: To analyze the association between early audiometric age-related hearing loss and brain β-amyloid, the pathologic hallmark of Alzheimer's disease (AD). STUDY DESIGN: Cross-sectional analysis of a prospective cohort study. METHODS: A cross-sectional analysis was performed on 98 participants in a cohort study of hearing and brain biomarkers of AD. The primary outcome was whole brain β-amyloid standardized uptake value ratio (SUVR) on positron emission tomography (PET). The exposure was hearing, as measured by either pure-tone average or word recognition score in the better ear. Covariates included age, gender, education, cardiovascular disease, and hearing aid use. Linear regression was performed to analyze the association between β-amyloid and hearing, adjusting for potentially confounding covariates. RESULTS: The mean age ± standard deviation was 64.6 ± 3.5 years. In multivariable regression, adjusting for demographics, education, cardiovascular disease, and hearing aid use, whole brain β-amyloid SUVR increased by 0.029 (95% confidence interval [CI]: 0.003-0.056) for every 10 dB increase in pure-tone average (P = .030). Similarly, whole brain β-amyloid SUVR increased by 0.061 (95% CI: 0.009-0.112) for every 10% increase in word recognition score (P = .012). CONCLUSIONS: Worsening hearing was associated with higher β-amyloid burden, a pathologic hallmark of AD, measured in vivo with PET scans. LEVEL OF EVIDENCE: 3 Laryngoscope, 131:633-638, 2021.
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